2006年5月
Inhibition of lipid accumulation and lipid body formation in oleaginous yeast by effective components in spices, carvacrol, eugenol, thymol, and piperine
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- ,
- ,
- 巻
- 54
- 号
- 10
- 開始ページ
- 3528
- 終了ページ
- 3534
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1021/jf0531149
- 出版者・発行元
- AMER CHEMICAL SOC
We screened natural organic compounds, which affected the lipid accumulation and the lipid body formation in oleaginous yeast, Lipomyces starkeyi, generating large lipid bodies. We found that four natural components in spices, carvacrol, thymol, eugenol, and piperine, inhibited the lipid accumulation at concentrations of 20-50 mg/L with a slight growth inhibition. The inhibitory effects were quantitatively represented by the total lipid accumulation amount, the triacylglycerol accumulation amount, and the average lipid body size. At 50 mg/L, the effects of these compounds were not identical and exhibited 11-37% decrease in lipid amount and 15-21% decrease in lipid body size with 13-39% decrease in cell growth. The inhibitory effect of these compounds lead to 30-69% decrease in triacylglycerol accumulation without any additional accumulation of its intermediates, suggesting that they will suppress the total carbon inflow into the triacylglycerol biosynthesis.
- リンク情報
- ID情報
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- DOI : 10.1021/jf0531149
- ISSN : 0021-8561
- CiNii Articles ID : 80019177480
- Web of Science ID : WOS:000237590600007