Penmetcha Kumar (PENMETCHA K. R. Kumar) - マイポータル

基本情報

所属: 独立行政法人産業技術総合研究所

学位: Ph . D.

J-GLOBAL ID: 200901057084339202
researchmap会員ID: 0000045084

外部リンク: http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=P77275104

研究キーワード

研究分野

ライフサイエンス / 構造生物化学 /

経歴

1993年5月 - 1994年6月

Research Associate (Indiana Univ. USA)
1994年

- NIBH
1991年 - 1993年

STA fellow (NIBH Japan),
1989年 - 1991年

Alexander Humboldt Fellow (Hanover Univ. Germany)

論文

112

Aptamers that bind to the human complement component receptor hC5aR1 interfere with hC5aR1 interaction to its hC5a ligand

Penmetcha K, R. Kumar

Molecular Biology Reports 45(5) 851 2018年10月査読有り
Targeting Herpes Simplex Virus-1 gD by a DNA Aptamer Can Be an Effective New Strategy to Curb Viral Infection

Molecular Therapy: Nucleic Acids 2017年12月査読有り
Systematic screening of viral entry inhibitors using surface plasmon resonance

Penmetcha K. R. Kumar

REVIEWS IN MEDICAL VIROLOGY 27(6) e1952 2017年11月査読有り
Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport

Yasuhara N, Kumar P.K.R

Journal of Biochemistry 160(5) 259-268 2016年11月査読有り
Aptamer selection methodologies

Penmetcha K.R. Kumar

Aptamers: Tools for Nanotherapy and Molecular Imaging 49-74 2016年6月9日査読有り
Monitoring intact viruses using aptamers

Penmetcha K.R. Kumar

Biosensors 6(3) 2016年査読有り
RNA-Directed Amino Acid Coupling as a Model Reaction for Primitive Coded Translation

Kazuo Harada, Shoko Aoyama, Akimasa Matsugami, Penmetcha K. R. Kumar, Masato Katahira, Nobuo Kato, Junko Ohkanda

CHEMBIOCHEM 15(6) 794-798 2014年4月査読有り
Topical application of polyethylenimine as a candidate for novel prophylactic therapeutics against genital herpes caused by herpes simplex virus

Kyoko Hayashi, Hiroki Onoue, Kohei Sasaki, Jung-Bum Lee, Penmetcha K. R. Kumar, Subash C. B. Gopinath, Yoshie Maitani, Takashi Kai, Toshimitsu Hayashi

ARCHIVES OF VIROLOGY 159(3) 425-435 2014年3月査読有り
An aptamer that binds efficiently to the hemagglutinins of highly pathogenic avian influenza viruses (H5N1 and H7N7) and inhibits hemagglutinin-glycan interactions

Emi Suenaga, Penmetcha K. R. Kumar

ACTA BIOMATERIALIA 10(3) 1314-1323 2014年3月査読有り
Physical Interaction between Bacterial Heat Shock Protein (Hsp) 90 and Hsp70 Chaperones Mediates Their Cooperative Action to Refold Denatured Proteins

Hitoshi Nakamoto, Kensaku Fujita, Aguru Ohtaki, Satoru Watanabe, Shoichi Narumi, Takahiro Maruyama, Emi Suenaga, Tomoko S. Misono, Penmetcha K. R. Kumar, Pierre Goloubinoff …

JOURNAL OF BIOLOGICAL CHEMISTRY 289(9) 6110-6119 2014年2月査読有り
Metal ion-dependent anti-termination of transcriptional regulation of ribonucleoprotein complexes

Penmetcha K.R. Kumar, Hiroshi Mizuno

Biophysical Reviews 6(2) 215-226 2014年査読有り
Biomolecular discrimination analyses by surface plasmon resonance

Subash C. B. Gopinath, Penmetcha K. R. Kumar

ANALYST 139(11) 2678-2682 2014年査読有り
Analysis of compounds that interfere with herpes simplex virus-host receptor interactions using surface plasmon resonance

Subash C. B. Gopinath, Kyoko Hayashi, Jung-Bum Lee, Akiko Kamori, Cai-Xia Dong, Toshimitsu Hayashi, Penmetcha K. R. Kumar

Analytical Chemistry 85(21) 10455-10462 2013年11月5日査読有り
Aptamers that bind to the hemagglutinin of the recent pandemic influenza virus H1N1 and efficiently inhibit agglutination

Subash C. B. Gopinath, Penmetcha K. R. Kumar

ACTA BIOMATERIALIA 9(11) 8932-8941 2013年11月査読有り
Alternative binding modes of L-histidine guided by metal ions for the activation of the antiterminator protein HutP of Bacillus subtilis

Balasundaresan Dhakshnamoorthy, Hiroshi Mizuno, Penmetcha K. R. Kumar

JOURNAL OF STRUCTURAL BIOLOGY 183(3) 512-518 2013年9月査読有り
Influenza virus surveillance using surface plasmon resonance

Emi Suenaga, Hiroshi Mizuno, Penmetcha K. R. Kumar

VIRULENCE 3(5) 464-470 2012年8月査読有り
Aptamer That Binds to the gD Protein of Herpes Simplex Virus 1 and Efficiently Inhibits Viral Entry

Subash C. B. Gopinath, Kyoko Hayashi, Penmetcha K. R. Kumar

JOURNAL OF VIROLOGY 86(12) 6732-6744 2012年6月査読有り
Monitoring influenza hemagglutinin and glycan interactions using surface plasmon resonance

Emi Suenaga, Hiroshi Mizuno, Kumar K. R. Penmetcha

BIOSENSORS & BIOELECTRONICS 32(1) 195-201 2012年2月査読有り
Signal changes for dye-complexed biomolecular interactions on waveguide-sensor chips

Subash C. B. Gopinath, Koichi Awazu, Makoto Fujimaki, Penmetcha K. R. Kumar

SENSORS AND ACTUATORS B-CHEMICAL 155(1) 239-244 2011年7月査読有り
A BioDVD Media with Multi layered Structure Is Suitable for Analyzing Biomolecular Interactions

Subash C. B. Gopinath, Penmetcha K. R. Kumar, Junji Tominaga

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 11(7) 5682-5688 2011年7月査読有り

もっとみる

MISC

A potent anti-coagulant RNA aptamer inhibits blood coagulation by specifically blocking the extrinsic clotting pathway

Subash C. B. Gopinath, Yasuo Shikamoto, Hiroshi Mizuno, Penmetcha K. R. Kumar

THROMBOSIS AND HAEMOSTASIS 95(5) 767-771 2006年5月
An efficient RNA aptamer against human influenza B virus hemagglutinin

SCB Gopinath, Y Sakamaki, K Kawasaki, PKR Kumar

JOURNAL OF BIOCHEMISTRY 139(5) 837-846 2006年5月
Structure of an RNA duplex r(GGCGBrUGCGCU)2 with terminal and internal tandem G・U base pairs

Acta Crystallographica Section D: Biological Crystallography 62(62) 331-338 2006年3月
Characterization and application of a novel RNA aptamer against the mouse prion protein

S Sekiya, K Noda, F Nishikawa, T Yokoyama, PKR Kumar, S Nishikawa

JOURNAL OF BIOCHEMISTRY 139(3) 383-390 2006年3月
An RNA aptamer that distinguishes between closely related human influenza viruses and inhibits haemagglutinin-mediated membrane fusion

SCB Gopinath, TS Misono, K Kawasaki, T Mizuno, M Imai, T Odagiri, PKR Kumar

JOURNAL OF GENERAL VIROLOGY 87(3) 479-487 2006年3月
Structural basis of HutP-mediated transcription anti-termination

PKR Kumar, T Kumarevel, H Mizuno

CURRENT OPINION IN STRUCTURAL BIOLOGY 16(1) 18-26 2006年2月
Aptamer-derived nucleic acid oligos: Applications to develop nucleic acid chips to analyze proteins and small ligands

R Yamamoto-Fujita, PKR Kumar

ANALYTICAL CHEMISTRY 77(17) 5460-5466 2005年9月
Selection of RNA aptamers against human influenza virus hemagglutinin using surface plasmon resonance

TS Misono, PKR Kumar

ANALYTICAL BIOCHEMISTRY 342(2) 312-317 2005年7月
Structural basis of HutP-mediated anti-termination and roles of the Mg2+ ion and L-histidine ligand

T Kumarevel, H Mizuno, PKR Kumar

NATURE 434(7030) 183-191 2005年3月
Human vault-associated non-coding RNAs bind to mitoxantrone, a chemotherapeutic compound

SCB Gopinath, A Matsugami, M Katahira, PKR Kumar

NUCLEIC ACIDS RESEARCH 33(15) 4874-4881 2005年
Characterization of the metal ion binding site in the anti-terminator protein, HutP, of Bacillus subtilis

T Kumarevel, H Mizuno, PKR Kumar

NUCLEIC ACIDS RESEARCH 33(17) 5494-5502 2005年
Selection of RNA aptamers against human influenza B virus

Nucleic Asids Symposium Series 49,85-86 2005年
Crystallization and preliminary X-ray diffraction studies of the metal-ion-mediated ternary complex of the HutP protein with L-histidine and its cognate RNA

TS Kumarevel, Z Fujimoto, H Mizuno, PKR Kumar

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1702(1) 125-128 2004年10月
Crystal structure of activated HutP: An RNA binding protein that regulates transcription of the hut operon in Bacillus subtilis

T Kumarevel, Z Fujimoto, P Karthe, M Oda, H Mizuno, PKR Kumar

STRUCTURE 12(7) 1269-1280 2004年7月
Identification of important chemical groups of the hut mRNA for HutP interactions that regulate the hut operon in Bacillus subtilis

TS Kumarevel, SCB Gopinath, S Nishikawa, H Mizuno, PKR Kumar

NUCLEIC ACIDS RESEARCH 32(13) 3904-3912 2004年
Structural basis of the highly efficient trapping of the HIV Tat protein by an RNA aptamer

A Matsugami, S Kobayashi, K Ouhashi, S Uesugi, R Yamamoto, K Taira, S Nishikawa, PKR Kumar, M Katahira

STRUCTURE 11(5) 533-545 2003年5月
Influence of medium- and long-range interactions in different folding types of globular proteins

TS Kumarevel, MM Gromiha, S Selvaraj, K Gayatri, PKR Kumar

BIOPHYSICAL CHEMISTRY 99(2) 189-198 2002年10月
CARF is a novel protein that cooperates with mouse p19(ARF) (human p14(ARF)) in activating p53

MK Hasan, T Yaguchi, T Sugihara, PKR Kumar, K Taira, RR Reddel, SC Kaul, R Wadhwa

JOURNAL OF BIOLOGICAL CHEMISTRY 277(40) 37765-37770 2002年10月
Crystallization and preliminary X-ray diffraction studies of HutP protein: an RNA-binding protein that regulates the transcription of hut operon in Bacillus subtilis

TS Kumarevel, Z Fujimoto, B Padmanabhan, M Oda, S Nishikawa, H Mizuno, PKR Kumar

JOURNAL OF STRUCTURAL BIOLOGY 138(3) 237-240 2002年6月
Application of aptamer-derived split oligos in micro-arrays for detection and analysis of cognate ligands (other than nucleic acids) in heterogeneous samples

2ND INTERNATIONAL CONFERENCE ON RNA IN DRUG DEVELOPMENT 2002年

もっとみる

共同研究・競争的資金等の研究課題

Structure-function relationship of RNA aptamer for HIV protein

産業財産権

短型肝炎ウイルスのNS3プロテアーゼを阻喜するRNA