2011年2月
Design and synthesis of highly solvatochromic fluorescent 2 '-deoxyguanosine and 2 '-deoxyadenosine analogs
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
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- 巻
- 21
- 号
- 4
- 開始ページ
- 1275
- 終了ページ
- 1278
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bmcl.2010.11.129
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
We synthesized various substituted 8-styryl-2'-deoxyguanosine and 8-styryl-2'-deoxyadenosine derivatives. Among them only acetyl substituted 8-styryl-2'-deoxyguanosine analog 5b showed a remarkable solvatochromicity (Delta lambda(em)(max) = 91 nm), that is, strong fluorescence at 477 nm in 1,4-dioxane, but in methanol the fluorescence was red shifted to 558 nm with very low intensity. Such environmentally sensitive solvatochromic fluorescent guanosine analogs may be useful as a sensor for investigating interactions of DNA with DNA binding proteins. (C) 2010 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.bmcl.2010.11.129
- ISSN : 0960-894X
- PubMed ID : 21273064
- Web of Science ID : WOS:000286972400040