2008年
Design and synthesis of biotinylated inositol phosphates relevant to the biotin-avidin techniques
ORGANIC & BIOMOLECULAR CHEMISTRY
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- 巻
- 6
- 号
- 10
- 開始ページ
- 1822
- 終了ページ
- 1830
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/b719938d
- 出版者・発行元
- ROYAL SOC CHEMISTRY
Six bifunctional molecules containing biotin and various inositol phosphates were synthesized. These compounds were designed on the basis of X-ray structures of the complexes of D-myo-inositol 1,4,5-triphosphates (IP(3)) and phospholipase C delta pleckstrin homology domain (PLC delta PH) considering the application to the biotin - avidin techniques. The building blocks of the inositol moiety were synthesized starting with optically resolved myo-inositol derivatives and assembled to the biotin linker through a phosphate linkage.
- リンク情報
- ID情報
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- DOI : 10.1039/b719938d
- ISSN : 1477-0520
- Web of Science ID : WOS:000255549600017