2005年2月3日
A ribonucleopeptide receptor targets phosphotyrosine
e-Journal of Surface Science and Nanotechnology
- ,
- ,
- ,
- 巻
- 3
- 号
- 開始ページ
- 33
- 終了ページ
- 37
- 記述言語
- 英語
- 掲載種別
- 研究論文(国際会議プロシーディングス)
- DOI
- 10.1380/ejssnt.2005.33
Tools for selective recognition and sensing of kinase-catalyzed phosphorylation at tyrosine or serine/threonine residues located on the protein surface are essential for understanding signal transduction cascades of living cell. A stable complex of RNA and peptide (ribonucleopeptide) provides a convenient approach to tailor a receptor for small molecules. In vitro selection of an RNA-derived pool of ribonucleopeptide afforded a ribonucleopeptide receptor specific for phosphotyrosine. The phosphotyrosine-binding ribonucleopeptide receptor discriminated phosphotyrosine against tyrosine, phosphoserine and phosphothreonine. © 2005 The Surface Science Society of Japan.
- ID情報
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- DOI : 10.1380/ejssnt.2005.33
- ISSN : 1348-0391
- SCOPUS ID : 18444417438