MISC

2007年10月

Age-related changes in BDNF protein levels in human serum: differences between autism cases and normal controls

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
  • Ritsuko Katoh-Semba
  • ,
  • Rie Wakako
  • ,
  • Taku Komori
  • ,
  • Hiroko Shigemi
  • ,
  • Noriko Miyazaki
  • ,
  • Hironori Ito
  • ,
  • Toshiyuki Kumagai
  • ,
  • Masako Tsuzuki
  • ,
  • Kenji Shigemi
  • ,
  • Futoshi Yoshida
  • ,
  • Atsuo Nakayama

25
6
開始ページ
367
終了ページ
372
記述言語
英語
掲載種別
DOI
10.1016/j.ijdevneu.2007.07.002
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Accumulating evidence suggests the possible association between the concentrations of serum brain-derived neurotrophic factor (BDNF) and psychiatric disease with impaired brain development. Yet the reasons remain unclear. We therefore investigated the characteristics of serum BDNF as well as its age-related changes in healthy controls in comparison to autism cases. BDNF was gradually released from platelets at 4 degrees C, reached a maximal concentration after around 24 h, and remained stable until 42 h. At room temperature, BDNF was found to be immediately degraded. Circadian changes, but not seasonal changes, were found in serum levels of BDNF existing as the mature form with a molecular mass of 14 kDa. In healthy controls, the serum BDNF concentration increased over the first several years, then slightly decreased after reaching the adult level. There were no sex differences between males and females. In the autism cases, mean levels were significantly lower in children 0-9 years old compared to teenagers or adults, or to age-matched healthy controls, indicating a delayed BDNF increase with development. In a separate study of adult rats, a circadian change in serum BDNF was found to be similar to that in the cortex, indicating a possible association with cortical functions. (c) 2007 ISDN. Published by Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 98

リンク情報
DOI
https://doi.org/10.1016/j.ijdevneu.2007.07.002
CiNii Resolver ID
http://ci.nii.ac.jp/nrid/9000239248799
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000251464800005&DestApp=WOS_CPL