論文

査読有り
2013年7月

Pancreatic Intraglandular Metastasis Predicts Poorer Outcome in Postoperative Patients With Pancreatic Ductal Carcinoma

AMERICAN JOURNAL OF SURGICAL PATHOLOGY
  • Seiji Oguro
  • ,
  • Kazuaki Shimada
  • ,
  • Yoshinori Ino
  • ,
  • Minoru Esaki
  • ,
  • Satoshi Nara
  • ,
  • Yoji Kishi
  • ,
  • Tomoo Kosuge
  • ,
  • Yae Kanai
  • ,
  • Nobuyoshi Hiraoka

37
7
開始ページ
1030
終了ページ
1038
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1097/PAS.0b013e3182834d22
出版者・発行元
LIPPINCOTT WILLIAMS & WILKINS

Intraorgan metastasis of a primary cancer within the organ of origin, such as intrahepatic metastasis of hepatocellular carcinoma, is one of the key features for clinicopathologic staging of the cancer. Pancreatic intraglandular metastasis (P-IM) of pancreatic ductal carcinoma (PDC) is encountered occasionally but has not yet been evaluated. The aim of this study was to investigate the clinicopathologic characteristics and prognostic value of P-IM in patients with PDC. The histopathologic features of 393 consecutive patients with PDC who had undergone pancreatic resection at the National Cancer Center Hospital, Tokyo, between 2003 and 2010 were reviewed. For the purposes of the study, P-IM was defined as an independent tumor showing histopathologic features similar to those of the primary one. Twenty-six cases of P-IM were identified in 21 (5.3%) of the reviewed patients. The incidence of P-IM at each stage of the TNM classification was 0% (0/7) at stage IA, 17% (1/6) at stage IB, 5% (5/92) at stage IIA, 4% (11/252) at stage IIB, 0% (0/1) at stage III, and 11% (4/35) at stage IV. Univariate survival analysis showed that both overall survival and disease-free survival for patients with P-IM were significantly shorter than for those without P-IM (P < 0.001 and P = 0.019, respectively). Multivariate survival analysis showed that P-IM was significantly correlated with shorter overall survival (P = 0.002; hazard ratio = 2.239; 95% confidence interval: 1.328-3.773). Our findings suggest that the presence of P-IM in patients with PDC is an independent prognosticator and may represent aggressive tumor behavior.

リンク情報
DOI
https://doi.org/10.1097/PAS.0b013e3182834d22
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/23648465
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000330377200012&DestApp=WOS_CPL
ID情報
  • DOI : 10.1097/PAS.0b013e3182834d22
  • ISSN : 0147-5185
  • eISSN : 1532-0979
  • PubMed ID : 23648465
  • Web of Science ID : WOS:000330377200012

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