論文

査読有り
2015年8月

Predictive Factors for Efficacy of Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes Mellitus

DIABETES & METABOLISM JOURNAL
  • Shusuke Yagi
  • Ken-ichi Aihara
  • Masashi Akaike
  • Daiju Fukuda
  • Hotimah Masdan Salim
  • Masayoshi Ishida
  • Tomomi Matsuura
  • Takayuki Ise
  • Koji Yamaguchi
  • Takashi Iwase
  • Hirotsugu Yamada
  • Takeshi Soeki
  • Tetsuzo Wakatsuki
  • Michio Shimabukuro
  • Toshio Matsumoto
  • Masataka Sata
  • 全て表示

39
4
開始ページ
342
終了ページ
347
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.4093/dmj.2015.39.4.342
出版者・発行元
KOREAN DIABETES ASSOC

Background: Predictive factors for the efficacy of dipeptidyl peptidase-4 (DPP-4) inhibitors for lowering glycosylated hemoglobin (HbA1c) remain unclear in patients with type 2 diabetes mellitus. The aim of this study is therefore to clarify predictive factors of the efficacy of DPP-4 inhibitors for lowering HbA1c after 12 months of treatment.
Methods: A total of 191 consecutive type 2 diabetic patients (male sex 55%, mean age, 68.3 +/- 35.8 years), who had been treated with DPP-4 inhibitors for 12 months, were enrolled in this study and evaluated retrospectively.
Results: After 12 months of DPP-4 inhibitor treatment, random blood glucose level, and HbA1c level, decreased from 167 +/- 63 to 151 +/- 49 mg/dL (P < 0.01), and from 7.5% +/- 1.3% to 6.9% +/- 0.9% (P < 0.01) respectively, without severe side effects. Multiple regression analysis showed that predictors of DPP-4 inhibitor treatment efficacy in lowering HbA1c level after 12 months were a decrease in HbA1c level after 3 months of treatment, a high baseline HbA1c level, a low baseline body mass index, and the absence of coronary artery disease.
Conclusion: Most suitable candidates for treatment with DPP-4 inhibitors are diabetics who are not obese and do not have coronary artery disease. In addition, long-term efficacy of DPP-4 inhibitors can be predicted by decrement of HbA1c after 3 months of treatment.

リンク情報
DOI
https://doi.org/10.4093/dmj.2015.39.4.342
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26301197
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000368002900010&DestApp=WOS_CPL
ID情報
  • DOI : 10.4093/dmj.2015.39.4.342
  • ISSN : 2233-6079
  • eISSN : 2233-6087
  • PubMed ID : 26301197
  • Web of Science ID : WOS:000368002900010

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