論文

査読有り 最終著者 責任著者
2010年2月

Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice

TOXICOLOGY LETTERS
  • Tomoko Matsuda
  • ,
  • Kohta Kurohane
  • ,
  • Yasuyuki Imai

192
2
開始ページ
97
終了ページ
100
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.toxlet.2009.10.009
出版者・発行元
ELSEVIER IRELAND LTD

Toxicological and epidemiological studies have suggested the involvement of di-(2-ethylhexyl) phthalate (DEHP) in increases in allergies. The effects of DEHP have been implicated in the deflection to T helper 2 (Th2)-biased immune responses. However, we could not observe an adjuvant effect of DEHP in a Th2-dominant fluorescein isothiocyanate (FITC)-induced contact hypersensitivity (CHS) mouse model when applied epicutaneously together with a hapten. In the present study, we focused whether there is a hapten to which DEHP exhibits an adjuvant effect through the epicutaneous route. BALB/c mice were epicutaneously sensitized with 2-methoxy-4-nitrophenyl isocyanate (MNICN) or phenethyl isocyanate (PEICN) in the presence or absence of phthalate esters of various kinds including DEHP. After challenge with a respective hapten, the ear-swelling response was measured to determine the level of hapten sensitization. Sensitization to MNICN and PEICN was enhanced when DEHP was present in the vehicle for the hapten preparation. The enhancement of sensitization to MNICN was accompanied by an elevated production of interferon-gamma and reduced production of interleukin-4 (IL-4), suggesting polarization to a T helper 1 (Th1)-dominant response. The results suggested that the combination of a hapten and a phthalate ester significantly affects the outcome of CHS. (C) 2009 Elsevier Ireland Ltd, All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.toxlet.2009.10.009
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19840837
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000274743300003&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.toxlet.2009.10.009
  • ISSN : 0378-4274
  • PubMed ID : 19840837
  • Web of Science ID : WOS:000274743300003

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