Hideshi Inoue

Profile Information

Affiliation: School of Life Science School of Life Science, Tokyo University of Pharmacy and Life Science

Degree: Doctor (Pharmaceutical Science)(The University of Tokyo)

J-GLOBAL ID: 200901079484031251
researchmap Member ID: 1000013862

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Professor Emeritus, Specially Appointed Professor, Tokyo University of Pharmacy and Life Sciences
Apr, 2022 - Mar, 2023

Vice-president, Tokyo University of Pharmacy and Life Sciences
Apr, 2006 - Mar, 2023

- 東京薬科大学生命科学部教授
Apr, 1995 - Mar, 2006

- 東京薬科大学生命科学部助教授
Apr, 1989 - Mar, 1995

Graduate School of Science, The University of Tokyo
1988 - 1989

日本学術振興会特別研究員(東北大学理学部)
1986 - 1988

(財)癌研究会癌研究所嘱託研究員

Education

Committee Memberships

評議員, 日本生化学会

Awards

1997

水島昭二記念研究賞，

Papers

Cacao Procyanidins-Induced Lifespan Extension in Caenorhabditis elegans in a Nervous System and CaMKII-Dependent Manner

Keiya Ohmine, Yuki Morinaga, Sarina Kobayashi, Aika Matsubara, Kaito Sadanaga, Shuhei Tohtani, Hideaki Saeki, Hiroto Horiuchi, Yuta Fujikawa, Koichiro Sumi …

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 79(4), Feb 16, 2024 Peer-reviewedLast authorCorresponding author
Development of a novel fluorogenic assay method for screening inhibitors of bovine leukemia virus (BLV) protease and identification of mitorubrinic acid as an anti-BLV compound.

Hironobu Murakami, Yuuta Fujikawa, Masaya Mori, Nozomi Mosu, Akihiro Taguchi, Yoshio Hayashi, Hideshi Inoue, Shinji Kamisuki

Bioscience, biotechnology, and biochemistry, Jun 6, 2023 Peer-reviewed
cis-Decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione S-transferase Noppera-bo.

Naoki Kato, Kana Ebihara, Toshihiko Nogawa, Yushi Futamura, Kazue Inaba, Akiko Okano, Harumi Aono, Yuuta Fujikawa, Hideshi Inoue, Kazuhiko Matsuda …

PloS one, 18(8) e0290851, 2023 Peer-reviewed
Improving reactivity of naphthalimide-based GST probe by imparting TPP cation: Development and application for live cell imaging.

Yuuta Fujikawa, Kenta Terakado, Sayaka Nezu, Kota Noritsugu, Yuki Maemoto, Akihiro Ito, Hideshi Inoue

Bioorganic & medicinal chemistry letters, 80 129109-129109, Dec 19, 2022 Peer-reviewedLast author
17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1.

Shohei Takase, Young Sook Yun, Fuki Moriya, Saaya Sekine, Satoshi Yotsumoto, Katsunori Miyake, Tadahiro Yahagi, Akihiro Ito, Hideshi Inoue

Journal of natural medicines, Oct 21, 2022 Peer-reviewedLast author
Pi-class Glutathione S-transferase (GSTP1)-selective fluorescent probes for multicolour imaging with various cancer-associated enzymes.

Yuuta Fujikawa, Masaya Mori, Minami Tsukada, Seiya Miyahara, Honoka Sato-Fukushima, Eita Watanabe, Yuko Murakami-Tonami, Hideshi Inoue

Chembiochem : a European journal of chemical biology, Sep 5, 2022 Peer-reviewedLast author
Design and synthesis of versatile GSTP1-specific fluorogenic substrates for the highly sensitive detection of GSTP1 activity in living cells.

Kodai Watanabe, Yuuta Fujikawa, Yuko Murakami-Tonami, Masaya Mori, Megumi Sakata, Hideshi Inoue

Talanta, 251 123796-123796, Aug 6, 2022 Peer-reviewedLast author
Retusone A, a Guaiane-Type Sesquiterpene Dimer from Wikstroemia retusa and Its Inhibitory Effects on Histone Acetyltransferase HBO1 Expression.

Young Sook Yun, Tomomi Nakano, Haruhiko Fukaya, Yukio Hitotsuyanagi, Miho Nakamura, Megumi Umetsu, Nobuko Matsushita, Katsunori Miyake, Hiroyuki Fuchino, Nobuo Kawahara …

Molecules (Basel, Switzerland), 27(9), May 3, 2022 Peer-reviewedLast author
Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti.

Kazue Inaba, Kana Ebihara, Miki Senda, Ryunosuke Yoshino, Chisako Sakuma, Kotaro Koiwai, Daisuke Takaya, Chiduru Watanabe, Akira Watanabe, Yusuke Kawashima …

BMC biology, 20(1) 43-43, Feb 17, 2022 Peer-reviewed
The plant-derived triterpenoid, cucurbitacin B, but not cucurbitacin E, inhibits the developmental transition associated with ecdysone biosynthesis in Drosophila melanogaster

Miwako Toyofuku, Daiki Fujinaga, Kazue Inaba, Tomoki Funahashi, Yuuta Fujikawa, Hideshi Inoue, Hiroshi Kataoka, Ryusuke Niwa, Hajime Ono

Journal of Insect Physiology, 134 104294-104294, Oct, 2021 Peer-reviewed
Garcinielliptone G from Garcinia subelliptica Induces Apoptosis in Acute Leukemia Cells

YoungSook Yun, Mariko Shioura, Yukio Hitotsuyanagi, Satoshi Yotsumoto, Yuji Takahashi, Yutaka Aoyagi, Takeshi Kinoshita, Koichi Takeya, Hideshi Inoue

Molecules, 26(9) 2422-2422, Apr 21, 2021 Peer-reviewedLast author
Non-steroidal inhibitors of Drosophila melanogaster steroidogenic glutathione S-transferase Noppera-bo

Kotaro Koiwai, Kana Morohashi, Kazue Inaba, Kana Ebihara, Hirotatsu Kojima, Takayoshi Okabe, Ryunosuke Yoshino, Takatsugu Hirokawa, Taiki Nampo, Yuuta Fujikawa …

Journal of Pesticide Science, 46(1) 75-87, Feb 20, 2021 Peer-reviewed
An integrated approach to unravel a crucial structural property required for the function of the insect steroidogenic Halloween protein Noppera-bo

Kotaro Koiwai, Kazue Inaba, Kana Morohashi, Sora Enya, Reina Arai, Hirotatsu Kojima, Takayoshi Okabe, Yuuta Fujikawa, Hideshi Inoue, Ryunosuke Yoshino …

Journal of Biological Chemistry, 295(20) 7154-7167, May 15, 2020 Peer-reviewed
The evolutionarily conserved deubiquitinase UBH1/UCH-L1 augments DAF7/TGF-β signaling, inhibits dauer larva formation, and enhances lung tumorigenesis

Asami Nagata, Fumiko Itoh, Ayaka Sasho, Kaho Sugita, Riko Suzuki, Hiroki Hinata, Yuta Shimoda, Eri Suzuki, Yuki Maemoto, Toshihiko Inagawa …

Journal of Biological Chemistry, 295(27) jbc.RA119.011222-jbc.RA119.011222, May 5, 2020 Peer-reviewedLast authorCorresponding author
Convenient synthesis of regioisomerically pure 5- and 6-functionalized xanthene dyes via SNAr reaction and comparison of their reactivity towards click reaction

Masaya Mori, Yuuta Fujikawa, Hideshi Inoue

Tetrahedron, 76(15) 131087-131087, Apr, 2020 Peer-reviewedLast author
Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.

Takuji Shoda, Nobumichi Ohoka, Genichiro Tsuji, Takuma Fujisato, Hideshi Inoue, Yosuke Demizu, Mikihiko Naito, Masaaki Kurihara

Pharmaceuticals (Basel, Switzerland), 13(3), Feb 25, 2020 Peer-reviewed
4-Bromo-1,8-naphthalimide derivatives as fluorogenic substrates for live cell imaging of glutathione S-transferase (GST) activity.

Fujikawa Y, Terakado K, Nampo T, Mori M, Inoue H

Talanta, 204 633-640, Nov, 2019 Peer-reviewedLast author
A highly selective fluorogenic substrate for imaging glutathione S-transferase P1: development and cellular applicability in epigenetic studies

Masaya Mori, Yuuta Fujikawa, Manami Kikkawa, Moeho Shino, Mei Sawane, Shiho Sato, Hideshi Inoue

Chemical Communications, 55(56) 8122-8125, Jul 18, 2019 Peer-reviewedLast author
Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives.

Genichiro Tsuji, Takayuki Hattori, Masashi Kato, Wataru Hakamata, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu, Takuji Shoda

Bioorganic & medicinal chemistry, 26(20) 5494-5498, Nov 1, 2018 Peer-reviewed
Exploration of Insect Growth Regulators Targeting Noppera-bo, an Enzyme Involved in Ecdysteroid Biosynthesis

Yuuta Fujikawa, Hideshi Inoue

YAKUGAKU ZASSHI, 138(8) 1043-1048, Aug 1, 2018

Misc.

111

ミトコンドリアH2O2産生系を用いたParkin依存性マイトファジーの解析

藤川雄太, 渡邉栄太, 太田胡桃, 池谷知美, 椎葉一心, 大塩聖, 柳茂, 井上英史

日本酸化ストレス学会学術集会プログラム・抄録集, 76th, 2023
Development of Iron Chelators for Regulation of Intracellular Iron Dynamics

山田侑奈, 藤川雄太, 大塩聖, 椎葉一心, 柳茂, 井上英史

日本薬学会年会要旨集(Web), 143rd, 2023
Development of fluorescent labeling reagents for glycoproteins

伊藤海結, 関根優莉奈, 正田卓司, 橋井則貴, 原園景, 石井明子, 井上英史, 出水庸介, 出水庸介

日本薬学会年会要旨集(Web), 143rd, 2023
骨髄性白血病治療を目指したNUP98-HOXA9の阻害剤探索

森屋風来, 高瀬翔平, 尹永淑, 三宅克典, 矢作忠弘, 伊藤昭博, 井上英史

日本薬学会年会要旨集, 142年会 28J-pm09S, Mar, 2022
CBX2とヒストンH3のタンパク質間相互作用を標的としたスクリーニング系の構築と天然物の探索

土肥沙弥香, 高瀬翔平, 尹永淑, 三宅克典, 矢作忠弘, 伊藤昭博, 井上英史, 一柳幸生

日本薬学会年会要旨集, 142年会 27PO1-51S, Mar, 2022
D-アミノ酸オキシダーゼを用いたミトコンドリアH2O2産生系によるマイトファジーの誘導

藤川雄太, 池谷知美, 渡邉栄太, 太田胡桃, 椎葉一心, 柳茂, 井上英史

日本生化学会大会(Web), 95th, 2022
Development of Selective Estrogen Receptor βDown-regulators Containing a Long Alkyl Chains

津田萌菜, 津田萌菜, 正田卓司, 平田尚也, 諫田泰成, 井上英史, 出水庸介, 出水庸介

日本薬学会年会要旨集(Web), 142nd, 2022
ネッタイシマカの脱皮ホルモン生合成制御因子Noppera-boに対する阻害剤の作用機序に関する構造生物学的研究

海老原佳奈, 稲葉和恵, 千田美紀, 小祝孝太郎, 高谷大輔, 渡邉千鶴, 安孫子ユミ, 今村理世, 岡部隆義, 小島宏建 …

日本蛋白質科学会年会プログラム・要旨集, 22nd (Web), 2022
Evaluation of mitophagy induced by mitochondrial H₂O₂ production system

池谷知美, 藤川雄太, 渡邉栄太, 井上英史

日本薬学会年会要旨集(Web), 142nd, 2022
Novel Insecticides Targeting the Molting Hormone Biosynthetic Pathway in Aedes aegypti

海老原佳奈, 稲葉和恵, 小祝孝太郎, 高谷大輔, 渡邉千鶴, 安孫子ユミ, 今村理世, 岡部隆義, 小島宏建, 佐久間知佐子 …

日本農芸化学会大会講演要旨集(Web), 2022, 2022
HBO1ヒストンアセチルトランスフェラーゼの発現を抑制する天然化合物の探索

中野朋美, 尹永淑, 梅津萌, 松下暢子, 三宅克典, 渕野裕之, 川原信夫, 高橋勇二, 井上英史

日本薬学会年会要旨集, 141年会 29V03-am11S, Mar, 2021
Construction of mitochondrial H₂O₂-producing system and evaluation of the effects of H₂O₂on mitochondria

池谷知美, 藤川雄太, 熊倉夏希, 井上英史

日本薬学会年会要旨集(Web), 141st, 2021
Development of acetylation-free fluorogenic GSTP1 substrates for the detection of intracellular GSTP1 activity in combination with an MRP inhibitor

渡邉幸大, 藤川雄太, 森雅矢, 坂田萌, 井上英史

日本薬学会年会要旨集(Web), 141st, 2021
Structure-activity relationship analysis of inhibitors targeting mosquito glutathione S-transferase Noppera-bo

稲葉和恵, 海老原佳奈, 小祝孝太郎, 吉野龍ノ介, 広川貴次, 今村理世, 小島宏建, 岡部隆義, 長野哲雄, 井上英史 …

量子ビームサイエンスフェスタ(Web), 2020, 2021
長鎖アルキル基を有する選択的エストロゲン受容体分解誘導剤の開発

津田萌菜, 津田萌菜, 正田卓司, 平田尚也, 諫田泰成, 井上英史, 出水庸介

日本薬学会関東支部大会講演要旨集, 65th (CD-ROM), 2021
HBO1の発現を抑制する天然化合物の探索

中野朋美, 尹永淑, 梅津萌, 松下暢子, 三宅克典, 渕野裕之, 川原信夫, 柳茂, 高橋勇二, 井上英史

日本薬学会年会要旨集, 140年会 28Q-pm129S, Mar, 2020
長鎖アルキル基を有するエストロゲン受容体分解誘導剤のERサブタイプ選択性に関する検討

津田萌菜, 正田卓司, 井上英史, 出水庸介

日本薬学会年会要旨集, 140年会 27P-am032S, Mar, 2020
植物トリテルペノイドcucurbitacin Bによるエクダイソン生合成の阻害

小野肇, 小野肇, 豊福美和子, 藤永大輝, 稲葉和恵, 船橋智輝, 藤川雄太, 井上英史, 片岡宏誌, 丹羽隆介 …

日本応用動物昆虫学会大会講演要旨, 64th, 2020
Cucurbitacins as bioactive substances for Drosophila development via sterol metabolisms

小野肇, 小野肇, 豊福美和子, 藤永大輝, 稲葉和恵, 船橋智輝, 藤川雄太, 井上英史, 片岡宏誌, 丹羽隆介 …

日本農薬学会大会講演要旨集, 45th, 2020
Development of fluorogenic substrates selective for GSTP1 and its applications

森雅矢, 藤川雄太, 井上英史

日本化学会春季年会講演予稿集(CD-ROM), 100th, 2020

Books and Other Publications

基礎講義情報科学：デジタル時代の新リテラシーを身につける

森河良太, 西田洋平, 野口瑶 (Role: Supervisor (editorial))

東京化学同人, Mar, 2024 (ISBN: 9784807920594)
基礎講義天然物医薬品化学 : アクティブラーニングにも対応

井上, 英史, 尹, 永淑

東京化学同人, Mar, 2022 (ISBN: 9784807920013)
基礎講義分子生物学 : アクティブラーニングにも対応

田中, 弘文, 井上, 英史 (Role: Joint editor)

東京化学同人, Sep, 2020 (ISBN: 9784807909971)
基礎講義生化学 : アクティブラーニングにも対応

井上英史 (Role: Editor)

東京化学同人, Sep, 2020 (ISBN: 9784807909964)
ダンラップ・ヒューリン創薬化学

Dunlap, Norma K., Huryn, Donna M., 長野, 哲雄 (Role: Joint translator)

東京化学同人, Mar, 2020 (ISBN: 9784807909933)
基礎講義生物学 : アクティブラーニングにも対応

井上, 英史, 都築, 幹夫 (Role: Joint editor)

東京化学同人, Mar, 2020 (ISBN: 9784807909728)
基礎講義物理学 : アクティブラーニングにも対応

石飛, 昌光, 高須, 昌子, 宮川, 毅, 森河, 良太, 井上, 英史 (Role: Supervisor (editorial))

東京化学同人, Dec, 2019 (ISBN: 9784807909711)
マクマリー生化学反応機構 : ケミカルバイオロジーによる理解

McMurry, John, Begley, Tadhg, 井上, 英史, 浦野, 泰照, 小島, 宏建, 鈴木, 紀行, 平野, 智也, 長野, 哲雄 (Role: Joint translator)

東京化学同人, Mar, 2018 (ISBN: 9784807909407)
Mechanistic study of the inhibition of glutathione S-transferase by C60

Fullerenes : Recent Advances in the Chemistry and Physics of Fullerenes and Related Materials, 1998
ライフサイエンス基礎実験 (共著)

(Role: Joint author)

丸善, Mar, 1996 (ISBN: 9784621041475)
基礎生化学実験(共著)

東京化学同人, Nov, 1994 (ISBN: 9784807904150)
錯体化学-基礎と最新の話題(共著)

(Role: Joint author)

講談社, Mar, 1994

Professional Memberships

Works

細胞内機能分子動態可視化解析のための技術の確立と応用

1998 - 2001

Research Projects

プロシアニジンによる老化抑制のメカニズム

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

井上英史
Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

HATTORI Akira, OISHI Shinya, FUJIWARA Hiroshi, INOUE Hideshi, MARUYAMA Masato, NISHIMURA Shinichi
High efficient screening for bioactive compounds using C. elegans mutant strains

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

INOUE Hideshi
線虫C. elegansを用いた生理活性物質の探索と標的因子の同定

科学研究費補助金, 2008
Post-genome analysis on proteolytic systems of multicellular organism

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2002

INOUE Hideshi
Molecular Biological Studies on the Proteases and .Their Inhibifors of Filarial Parasites

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1999 - 2001

TAKAHASHI Kenji, YAMAGATA Hideo, KOJIMA Masaki, INOUE Hideshi
Post-genome study on filarial proteases for development of inhibitors.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1999 - 2000

HIDESHI Inoue, KOJIMA Masaki, TAKAHASHI Kenji
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 1999 - 1999

井上英史, 高橋健治
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化

科学研究費助成事業, 特定領域研究(A), 日本学術振興会, 1998 - 1998

井上英史, 小島正樹, 高橋健治
Structural, Functional and Physiological Characterization of Novel Brain-Gut Proteinases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1997 - 1998

TAKAHASHI Kenji, NISHII Wataru, KOJIMA Masaki, INOUE Hideshi
Studies on Filarial Proteinases and Their Inhibitors for Development of Filarial Drugs

Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research, Japan Society for the Promotion of Science, 1996 - 1998

TAKAHASHI Kenji, KOJIMA Masaki, INOUE Hideshi, ATHOUDA Senarath B.P., WINALASIRI Weerappuli R., DISSONAYAKE Senarath
精密金属錯体の分子設計と生体機能

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 1997 - 1997

長野哲雄, 中村聡, 小澤俊彦, 大塚雅巳, 大倉一郎, 井上英史
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1997 - 1997

井上英史, 小島正樹, 高橋健治
線虫類プロテオリシス系の網羅的・系統的機能解析

科学研究費補助金, 1997
Study on the proteolytic systems of nematodes

Grant-in-Aid for Scientific Research, 1997
立体構造と蛋白工学的解析に基づくグルタチオン・トランスフェラーゼの機能発現機構

科学研究費助成事業, 基盤研究(C), 日本学術振興会, 1996 - 1996

井上英史, 小島正樹, 高橋健治
環境汚染物質の除去を目的としたハロゲン化炭素水素代謝酵素の蛋白工学的研究

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1996 - 1996

高橋健治, 小島正樹, 井上英史
Systematic search for novel proteinases in gastrointestinal tract and studies on their physiological roles and structure/function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 1995 - 1996

TAKAHASHI Kenji, KOJIMA Masaki, INOUE Hideshi
環境汚染物質の除去を目的としたハロゲン化炭化水素代謝酵素の蛋白工学的研究

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1995 - 1995

高橋健治, 井上英史
非ペプシン型カルボキシルプロテアーゼ活性中心の検索と構造機能相関

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1994 - 1994

井上英史

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