深町博史 (Hiroshi Fukamachi) - マイポータル

基本情報

学位: 理学博士(東京大学)

J-GLOBAL ID: 200901045021137369
researchmap会員ID: 1000013874

外部リンク: http://www.tmd.ac.jp/grad/monc/index.html

研究キーワード

研究分野

論文

Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models

Shu Shimada, Yoshimitsu Akiyama, Kaoru Mogushi, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Hiromi Nagasaki, Hiroshi Fukamachi, Yasuhito Yuasa, Shinji Tanaka

British Journal of Cancer 118(7) 972-984 2018年4月1日査読有り
Runx3 transcription factor regulates ovarian functions and ovulation in female mice

Fumiya Ojima, Yuka Saito, Yukiko Tsuchiya, Daichi Kayo, Syusuke Taniuchi, Maho Ogoshi, Hiroshi Fukamachi, Sakae Takeuchi, Sumio Takahashi

JOURNAL OF REPRODUCTION AND DEVELOPMENT 62(5) 479-486 2016年10月査読有り
Proteasome activity is required for the initiation of precancerous pancreatic lesions

Takaki Furuyama, Shinji Tanaka, Shu Shimada, Yoshimitsu Akiyama, Satoshi Matsumura, Yusuke Mitsunori, Arihiro Aihara, Daisuke Ban, Takanori Ochiai, Atsushi Kudo …

SCIENTIFIC REPORTS 6 27044 2016年5月査読有り
CD73 as a therapeutic target for pancreatic neuroendocrine tumor stem cells

Eriko Katsuta, Shinji Tanaka, Kaoru Mogushi, Shu Shimada, Yoshimitsu Akiyama, Arihiro Aihara, Satoshi Matsumura, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai …

INTERNATIONAL JOURNAL OF ONCOLOGY 48(2) 657-669 2016年2月査読有り
Activin A regulates growth of gastro-intestinal epithelial cells by mediating epithelial-mesenchymal interaction

Hiroshi Fukamachi, Shinko Kato, Makoto Asashima, Masao Ichinose, Yasuhito Yuasa

Development Growth and Differentiation 55(9) 786-791 2013年12月査読有り
A patient-derived xenograft mouse model generated from primary cultured cells recapitulates patient tumors phenotypically and genetically

Hyang Sook Seol, Young-Ah Suh, Young-joon Ryu, Hyun Jung Kim, Sung Min Chun, Deuk Chae Na, Hiroshi Fukamachi, Seong-Yun Jeong, Eun Kyung Choi, Se Jin Jang

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 139(9) 1471-1480 2013年9月査読有り
CD49f(high) Cells Retain Sphere-Forming and Tumor-Initiating Activities in Human Gastric Tumors

Hiroshi Fukamachi, Hyang Sook Seol, Shu Shimada, Chikako Funasaka, Kanako Baba, Ji Hun Kim, Young Soo Park, Mi Jeung Kim, Keiji Kato, Mikito Inokuchi …

PLOS ONE 8(8) e72438 2013年8月査読有り
Runx3 Expression and Its Roles in Mouse Endometrial Cells

Yukiko Tsuchiya, Yuka Saito, Shusuke Taniuchi, Atsuko Sakuma, Tetsuya Maekawa, Hiroshi Fukamachi, Sakae Takeuchi, Sumio Takahashi

JOURNAL OF REPRODUCTION AND DEVELOPMENT 58(5) 592-598 2012年10月査読有り
Runx3 Protects Gastric Epithelial Cells Against Epithelial-Mesenchymal Transition-Induced Cellular Plasticity and Tumorigenicity

Dominic Chih-Cheng Voon, Huajing Wang, Jason Kin Wai Koo, Tu Anh Pham Nguyen, Yit Teng Hor, Yeh-Shiu Chu, Kosei Ito, Hiroshi Fukamachi, Shing Leng Chan, Jean Paul Thiery …

STEM CELLS 30(10) 2088-2099 2012年10月査読有り
Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer

Shu Shimada, Ayako Mimata, Masaki Sekine, Kaoru Mogushi, Yoshimitsu Akiyama, Hiroshi Fukamachi, Jos Jonkers, Hiroshi Tanaka, Yoshinobu Eishi, Yasuhito Yuasa

GUT 61(3) 344-353 2012年3月査読有り
CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation

Hiroshi Fukamachi, Shu Shimada, Kosei Ito, Yoshiaki Ito, Yasuhito Yuasa

CANCER SCIENCE 102(7) 1313-1321 2011年7月査読有り
Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer

Ayako Mimata, Hiroshi Fukamachi, Yoshinobu Eishi, Yasuhito Yuasa

CANCER SCIENCE 102(5) 942-950 2011年5月査読有り
Loss of Runx3 Is a Key Event in Inducing Precancerous State of the Stomach

Kosei Ito, Linda Shyue Huey Chuang, Tomoko Ito, Ti Ling Chang, Hiroshi Fukamachi, Manuel Salto-Tellez, Yoshiaki Ito

GASTROENTEROLOGY 140(5) 1536-U233 2011年5月査読有り
miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer

Rie Wada, Yoshimitsu Akiyama, Yutaka Hashimoto, Hiroshi Fukamachi, Yasuhito Yuasa

INTERNATIONAL JOURNAL OF CANCER 127(5) 1106-1114 2010年9月査読有り
Claudin-1 Has Tumor Suppressive Activity and Is a Direct Target of RUNX3 in Gastric Epithelial Cells

Ti Ling Chang, Kosei Ito, Tun Kiat Ko, Qiang Liu, Manuel Salto-Tellez, Khay Guan Yeoh, Hiroshi Fukamachi, Yoshiaki Ito

GASTROENTEROLOGY 138(1) 255-265 2010年1月査読有り
Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice

Atsuko Sakuma, Hiroshi Fukamachi, Kosei Ito, Yoshiaki Ito, Sakae Takeuchi, Sumio Takahashi

MOLECULAR REPRODUCTION AND DEVELOPMENT 75(11) 1653-1661 2008年11月査読有り
RUNX3 attenuates β-catenin/T cell factors in intestinal tumorigenesis.

ITO Kosei, ITO Kosei, LIM Anthony Chee-Beng, SALTO-TELLEZ Manuel, MOTODA Lena, OSATO Motomi, OSATO Motomi, CHUANG Linda, Shyue Huey, LEE Cecilia Wei Lin …

Cancer Cell 14(3) 226-237 2008年9月査読有り
In vitro differentiation of Runx3(-/-)p53(-/-) gastric epithelial cells into intestinal type cells

Hiroshi Fukamachi, Ayako Mimata, Issei Tanaka, Kosei Ito, Yoshiaki Ito, Yasuhito Yuasa

CANCER SCIENCE 99(4) 671-676 2008年4月査読有り
IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells

Shun-Hua Jin, Yoshimitsu Akiyama, Hiroshi Fukamachi, Kazuyoshi Yanagihara, Takumi Akashi, Yasuhito Yuasa

INTERNATIONAL JOURNAL OF CANCER 122(5) 1040-1046 2008年3月
Developmentally regulated expression of matrix metalloproteinases during fetal rat colon morphogenesis

Hidenori Kurakata, Masashi Oka, Yasuo Matsubara, Tohru Niwa, Hirotoshi Utsunomiya, Mitsuhiro Fujishiro, Kazumasa Miki, Hiroshi Fukamachi, Syunichiro Kubota, Masao Ichinose

DEVELOPMENT GROWTH & DIFFERENTIATION 50(1) 41-48 2008年1月査読有り

もっとみる

MISC

受容体型プロテインチロシンホスファターゼξ(Ptpzξ)遺伝子欠損マウスはHelicobacter pyloriのVacA毒素による胃潰瘍発症に抵抗性である。

日本ヘリコバクター学会誌 5, 5-8 2004年
Runx3による胃上皮細胞の増殖とアポトーシスの制御

細胞工学 21, 1203-1206 2002年
Runxと癌

Mo1.Med. 39, 1304-1313 2002年
転写制御因子Fkh6ノックアウトマウスにおける消化管形成異常

Frontier Gastroenterol. 6,169-175 2001年
Role of FGF Family Genes in Development (in Japanese)

Protein, Nucleic Acid and Enzyme 10, 38-47 1992年
Role of Tissue Interactions in Organogenesis (in Japanese)

Mebio 3, 73-76 1986年

書籍等出版物

(2006) Gastric cancer, intestinal metaplasia and Runx3. In: Recent Advances in Gastrointestinal Carcinogenesis (eds. H. Bamba and S. Ota)

Transworld Res. Network, Kerala, India. 2006年
The developing Xenopus embryo as a complex system : Maternal and zygotic contribution of gene products in nucleo-cytoplasmic and cell-to-cell interactions

Complexity and Diversity 1997年
消化管上皮細胞培養法

組織培養の技術(第3版)基礎編、朝倉書店 1996年
Induction of the genes for hepatocyte growth factor and keratinocyte growth factor in the pyloric mucosa of rat stomach by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG)and sodium chloride(NaCl

Recent Advances in Gastroenterological Carcinogenesis I 1996年
Effect of hydrocortisone on the pepsinogen-producing cells in the stomach mucosa

Aspartic Proteases : Structure, Function, Biology, and Biomedical Implications (ed. K. Takahashi), Plenum Press, New York 1995年
Effect of omeprazole, a proton pump inhibitor, on pepsinogen-producing cells, with special reference to neonatal development

Aspartic Proteases : Structure, Function, Biology, and Biomedical Implications (ed. K. Takahashi), Plenum Press, New York 1995年
Tissue- and cell- specific control of guinea pig cathepsin E gene expression

Aspartic Proteases : Structure, Function, Biology, and Biomedical Implications (ed. K. Takahashi), Plenum Press, New York 1995年
Cathepsin E is expressed in fetal rat glandular stomach epithelial cells in primary culture in the absence of mesenchymes

Aspartic Proteases : Structure, Function, Biology, and Biomedical Implications (ed. K. Takahashi), Plenum Press, New York 1995年
Isolation and culture of mouse uterine epithelial and stromal cells

Methods in Toxicology, Vol. 3B, Female Reproductive Toxicology 1993年
発生生物学 : 分子から形態進化まで(共訳)

トッパン 1991年
Developmental Biology(Scott Gilbert; tranlated into Japanese)

Toppan 1991年
Epithelial-Mesenchymal Interactions and Carcinogenesis in Digestive Organs (in Japanese)

Soft Science 1984年

所属学協会

Works(作品等)

Runx3遺伝子による胃上皮細胞の増殖調節

1998年 - 2004年
Runx3 is a major growth regulator of gastric epithelial cells

1998年 - 2003年

共同研究・競争的資金等の研究課題

消化管上皮細胞の増殖と分化の調節機構
がん幹細胞の同定と造腫瘍性の調節機構の解明

科学研究費補助金
胃の腸上皮化生形成におけるRunx3の機能

科学研究費補助金
Molecular mechanism of gastro intestinal tumorigenesis

Grant-in-Aid for Scientific Research
Molecular mechanism controlling proliferation and apoptosis of intestinal epithelial cells

Grant-in-Aid for Scientific Research
Molecular mechanism controlling proliferation and differentiation of stomach epithelial cells

Grant-in-Aid for Scientific Research