2018年7月2日
Tumor-dependent secretion of close homolog of L1 results in elevation of its circulating level in mouse model for human lung tumor
Biochemical and Biophysical Research Communications
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- 巻
- 501
- 号
- 4
- 開始ページ
- 982
- 終了ページ
- 987
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1016/j.bbrc.2018.05.096
- 出版者・発行元
- Elsevier B.V.
Close homolog of L1 (CHL1) and its truncated form mainly play crucial roles in mouse brain development and neural functions. Herein, we newly identified that truncated form of CHL1 is produced and released from lung tumor tissue in a mouse model expressing human EML4-ALK fusion gene. Both western blot and direct ELISA analysis revealed that mouse CHL1 level in serum (including serum extracellular vesicles) was significantly elevated in EML4-ALK transgenic mice. The correlation between the tumor size and the amount of CHL1 secretion could be examined in this study, and showed a significant positive correlation in a tumor size-dependent manner. Considering these results, the measurement of circulating CHL1 level may contribute to assess a tumor progression in human lung tumor patients.
- ID情報
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- DOI : 10.1016/j.bbrc.2018.05.096
- ISSN : 1090-2104
- ISSN : 0006-291X
- SCOPUS ID : 85047312155