2000年10月
Experience with freeze-dried PGLA/HA/rhBMP-2 as a bone graft substitute
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
- ,
- ,
- ,
- 巻
- 28
- 号
- 5
- 開始ページ
- 294
- 終了ページ
- 299
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1054/jems.2000.0161
- 出版者・発行元
- CHURCHILL LIVINGSTONE
We investigated bone induction by recombinant human bone morphogenetic protein-2 in rodents. The purpose of this study was to evaluate the osteoinductive potential of a resorbable bone substitute fabricated from freeze-dried poly(glycolic acid-co-lactic acid) (PGLA) mixed with hydroxyapatite particles incorporated with bone morphogenetic protein-2 in skull defects of rats (FD-PGLA/HA/rhBMP-2). The FD-PGLA/HA/rhBMP-2 composite or as a control, the FD-PGLA/HA by itself were implanted in skull defects (empty set 8 mm) of rats. The samples were harvested at 2 or 4 weeks postoperatively and were studied radiographically and histologically. Four weeks after implantation, the FD-PGLA/HA/rhBMP-2 discs were completely replaced by newly-formed bone possessing bone marrow. In contrast, the defects implanted with FD-PGLA/HA were filled only with fibrous connective tissue. The results suggest that the FD-PGLA/HA/rhBMP-2 composite could be an optimum bone substitute with osteoinductive potential and could function as an alternative bone graft material for autogenous bone in humans. (C) 2000 European Association for Cranio-Maxillofacial Surgery.
- リンク情報
- ID情報
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- DOI : 10.1054/jems.2000.0161
- ISSN : 1010-5182
- Web of Science ID : WOS:000166802900007