Keiko Yamamoto

Profile Information

Affiliation: Professor, Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University

Degree: (BLANK)(Chiba University)

Researcher number: 90147017
ORCID ID: https://orcid.org/0000-0001-6642-7961
J-GLOBAL ID: 200901009313030267
researchmap Member ID: 1000014445

External link: http://www.shoyaku.ac.jp/laboratory/iyaku.html

Research Interests

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development /

Research History

Education

1973 - 1977

Faculty of Pharmaceutical Science, Chiba University
Chiba University

Committee Memberships

Awards

Major Papers

116

Interaction between mitochondrial CYP27B1 and adrenodoxin: Role of arginine 458 of mouse CYP27B1

N Urushino, K Yamamoto, N Kagawa, S Ikushiro, M Kamakura, S Yamada, S Kato, K Inouye, T Sakaki

BIOCHEMISTRY, 45(14) 4405-4412, Apr, 2006

Misc.

STEREOSELECTIVE SYNTHESIS OF (25R)-25,26-DIHYDROXY-23-OXOVITAMIN-D3 AND ITS ENZYMATIC CONVERSION TO (25R)-1-ALPHA,25,26-TRIHYDROXY-23-OXOVITAMIN-D3, A PUTATIVE METABOLITE OF VITAMIN-D3

S YAMADA, K NAKAYAMA, H TAKAYAMA, T SHINKI, T SUDA

TETRAHEDRON LETTERS, 25(30) 3239-3242, 1984
STUDIES OF VITAMIN-D OXIDATION .4. REGIOSELECTIVE AND STEREOSELECTIVE EPOXIDATION OF VITAMIN-D

K NAKAYAMA, S YAMADA, H TAKAYAMA, Y NAWATA, Y IITAKA

JOURNAL OF ORGANIC CHEMISTRY, 49(9) 1537-1539, 1984
ISOLATION, IDENTIFICATION, AND METABOLISM OF (23S,25R)-25-HYDROXYVITAMIN-D3 26,23-LACTOL - A BIOSYNTHETIC PRECURSOR OF (23S,25R)-25-HYDROXYVITAMIN-D3 26,23-LACTONE

S YAMADA, K NAKAYAMA, H TAKAYAMA, T SHINKI, Y TAKASAKI, T SUDA

JOURNAL OF BIOLOGICAL CHEMISTRY, 259(2) 884-889, 1984
STEREOSELECTIVE SYNTHESIS OF (25R)-25,26-DIHYDROXY-23-OXOVITAMIN-D3 AND ITS ENZYMATIC CONVERSION TO (25R)-1-ALPHA,25,26-TRIHYDROXY-23-OXOVITAMIN-D3, A PUTATIVE METABOLITE OF VITAMIN-D3

S YAMADA, K NAKAYAMA, H TAKAYAMA, T SHINKI, T SUDA

TETRAHEDRON LETTERS, 25(30) 3239-3242, 1984
STUDIES OF VITAMIN-D OXIDATION .4. REGIOSELECTIVE AND STEREOSELECTIVE EPOXIDATION OF VITAMIN-D

K NAKAYAMA, S YAMADA, H TAKAYAMA, Y NAWATA, Y IITAKA

JOURNAL OF ORGANIC CHEMISTRY, 49(9) 1537-1539, 1984
ISOLATION, IDENTIFICATION, AND METABOLISM OF (23S,25R)-25-HYDROXYVITAMIN-D3 26,23-LACTOL - A BIOSYNTHETIC PRECURSOR OF (23S,25R)-25-HYDROXYVITAMIN-D3 26,23-LACTONE

S YAMADA, K NAKAYAMA, H TAKAYAMA, T SHINKI, Y TAKASAKI, T SUDA

JOURNAL OF BIOLOGICAL CHEMISTRY, 259(2) 884-889, 1984
活性型ビタミンDの側鎖の立体配座を固定したアナログの設計,合成及び生理活性

東京医科歯科大学医用器材研究所報告, 27,21-32, 1993
Design, Synthesis and Biological Activities of Active Vitamin D₃ Analogs with Restricted Side Chain Conformation

Reports of the Institute for Medical & Dental Engineering., 27,21-32, 1993
ビタミンD作用発現機構解明をめざして:有機化学的視点から

東京医科歯科大学医用器材研究所報告, 31 13-20, 1997
Study on the mechanism of vitamin D action : from the standpoint of organic chemistry

Reports of the Institute for Medical & Dental Engineering, 31 13-20, 1997
1.活性型ビタミンDアナログのコンピューターグラフィック解析と構造活性相関 : 脂溶性ビタミン総合研究委員会第272回会議研究発表要旨

山田幸子, 山本恵子

ビタミン, 71(1) 29-29, Jan 25, 1997
Diastereoselectivity and Mechanism of Conjugate Addition of Organo cuprates to α-chiral Acyclic Enones and Enoates

Keiko YAMAMOTO, Sachiko YAMADA

Journal of Synthetic Organic Chemistry, Japan, 57(9) 763-774, 1999
Structure-Function Relationship of Vitamin D

BIO Clinica, 14 1161-1167, 1999
有機銅試薬の共役付加反応における面選択性と反応機構:一般則の提案

山本恵子, 山田幸子

有機合成化学協会誌, 57(9) 763-774, 1999
ビタミンDの三次元構造活性相関

ビタミン, 73 511-525, 1999
新しいビタミンD誘導体と構造活性相関

14 1161-1167, 1999
核内レセプターリガンド結合領域の立体構造とリガンド認識

増野弘幸, 山本惠子, 山田幸子

生体材料工学研究所年報, 33(33) 5-13, 1999
Three-Dimensional Structure-Function Relationship of Vitamin D

73 511-525, 1999
Structure-Function Relationship of Vitamin D

BIO Clinica, 14 1161-1167, 1999
Three-Dimensional Structure of Nuclear Receptor and Ligand-Recognition

33 5-13, 1999

Books and Other Publications

Vitamin D Receptor. In: Hochberg Z, editor. Endocr. Dev.: Vitamin D and Rickets.

KARGER:Basel, 2003
Vitamin D Receptor. In: Hochberg Z, editor. Endocr. Dev.: Vitamin D and Rickets.

KARGER:Basel, 2003
Three-Dimensional Structure and Function of Nuclear Receptor Ligand-Binding Domain

2000
核内レセプターリガンド結合領域の立体構造と機能

実験医学, 2000
Three-Dimensional Structure and Function of Nuclear Receptor Ligand-Binding Domain

2000
In vivo metabolism of 24R, 25-Dihydroxyvitamin D₃ : Identification of its major bile metabolite

Vitamin D : Chemistry, Biology and Clinical Applications of the Steroid Hormone, 1997
Side-chain Conformation and activity of vitamin D : Design, Syntheses, and Biological Activities of Conformationally Restricted Analogs

Vitamin D : Chemistry, Biology and Clinical Applications of the Steroid Hormone, 1997
In vivo metabolism of 24R, 25-Dihydroxyvitamin D₃ : Identification of its major bile metabolite

Vitamin D : Chemistry, Biology and Clinical Applications of the Steroid Hormone, 1997
Side-chain Conformation and activity of vitamin D : Design, Syntheses, and Biological Activities of Conformationally Restricted Analogs

Vitamin D : Chemistry, Biology and Clinical Applications of the Steroid Hormone, 1997
Syntheses and Biological Activity of 1β-Substituted Active Vitamin D₃ Analogs

Vitamin D A Pluripotent Steroid Hormone : Structural Studies, Molecular Endcrinology and Clinical Applications, 1994
Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region

Vitamin D A Pluripotent Steroid Hormone : Structural Studies, Molecular Endcrinology and Clinical Applications, 1994
Introduction of 1α-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions

Vitamin D A Pluripotent Steroid Hormone : Structural Studies, Molecular Endcrinology and Clinical Applications, 1994
Syntheses and Biological Activity of 1β-Substituted Active Vitamin D₃ Analogs

Vitamin D A Pluripotent Steroid Hormone : Structural Studies, Molecular Endcrinology and Clinical Applications, 1994
Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region

Vitamin D A Pluripotent Steroid Hormone : Structural Studies, Molecular Endcrinology and Clinical Applications, 1994
Introduction of 1α-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions

Vitamin D A Pluripotent Steroid Hormone : Structural Studies, Molecular Endcrinology and Clinical Applications, 1994
25-Hydroxy-24-oxovitamin D₃ is a Natural Metabolite under Physiological Conditions

Walter de Gruyter (Berlin, New York), 1988
25-Hydroxy-24-oxovitamin D₃ is a Natural Metabolite under Physiological Conditions

Walter de Gruyter (Berlin, New York), 1988

Professional Memberships

Works

Research Projects

Systematic synthesis and functional analysis of vitamin D receptor cofactor peptides

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020

YAMAMOTO Keiko
Development of reversible covalent vitamin D receptor ligands

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Yamamoto Keiko
生体分子コバレント修飾の革新的解析拠点形成

私立大学戦略的研究基盤形成支援事業, 2013 - 2017
メカニズムを基盤としたデザインと先端的合成法による画期的な次世代医薬品候補化合物の創出

創薬等支援技術基盤プラットフォーム事業, 2012 - 2016
Discovery of ligands that modulate the pocket structure of vitamin D receptor

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

YAMAMOTO Keiko
Role of ligands for allosteric network of nuclear receptors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

YAMAMOTO Keiko, YOSHIDA Yuki, ITOH Toshimasa
Chemical biological approach for regulation of gene expression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2007 - 2010

KAGECHIKA Hiroyuki, HIRANO Tomoya, YAMAMOTO Keiko, SHUDO Koichi
Development of antidiabetic agents targeting PPARγ

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2004 - 2005

YAMAMOTO Keiko, YAMADA Sachiko
Studies on response element of vitamin D target genes and discrimination of vitamin D actions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2002 - 2003

YAMAMOTO Keiko, YAMADA Sachiko
Regulation of tissue factor and thrombomodulin expressions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2001 - 2003

KOYAMA Takatoshi, YAMAMOTO Keiko
チトクロームP450の三次元構造と機能解析

2001
De novo design and synthesis of aromatic vitamain D analogs having rigid three-dimensional structure and differential activity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B)., Japan Society for the Promotion of Science, 1999 - 2000

YAMADA Sachiko, YAMAMOTO Keiko, SHIMIZU Masato, REISCHL Wolfgang
メタボリックシンドロームをターゲットとする新規PPARリガンドの開発

2000
Three-dimensional structure of vitamin D ligand-receptor complex and its intracellular interaction

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 1999

SHIMIZU Masato, YAMAMOTO Keiko, YAMADA Sachiko
核内受容体を分子標的とする創薬研究

1998
Confromational analysis of fluorovitamin D analogs interacting with vitamin D receptor using ^<19>F-NMR spectroscopy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1996 - 1997

SHIMIZU Masato, YAMAMOTO Keiko, YAMADA Sachiko
Active Vitamin D Analogs with Restricted Conformation Mobility : Synthesis, Receptor Binding and Regulation of Gene Expression

Grants-in-Aid for Scientific Research, Grant-in-Aid for international Scientific Research, Japan Society for the Promotion of Science, 1996 - 1997

YAMADA Sachiko, YAMAMOTO Keiko, SHIMIZU Masato, DELUCA H.F.
Conformational Analysis of Vitamin D Resposible for Binding to VDR and DBP

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1995 - 1996

YAMAMOTO Keiko, SHIMIZU Masato, YAMADA Sachiko
Studies on the conformation of active form of vitamin D responsible for binding to the receptor and for expression of the activities

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1994 - 1995

YAMADA Sachiko, YAMAMOTO Keiko, SHIMIZU Masato
ビタミンD受容体の遺伝子転写機構に関する構造生物学的研究

1995

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Awards

Major Papers

Misc.

Books and Other Publications

Professional Memberships

Works

Research Projects

Industrial Property Rights

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