MISC

2008年2月

Periodontitis may increase the risk of peripheral arterial disease

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
  • Y. -W. Chen
  • ,
  • M. Umeda
  • ,
  • T. Nagasawa
  • ,
  • Y. Takeuchi
  • ,
  • Y. Huang
  • ,
  • Y. Inoue
  • ,
  • T. Iwai
  • ,
  • Y. Izumi
  • ,
  • I. Ishikawa

35
2
開始ページ
153
終了ページ
158
記述言語
英語
掲載種別
DOI
10.1016/j.ejvs.2007.08.016
出版者・発行元
W B SAUNDERS CO LTD

Objectives. The aim of this case control study was to evaluate whether periodontitis was associated with peripheral arterial disease (PAD). Subjects and
Methods. Twenty-five patients diagnosed with aorto-iliac and/or femoro-popliteal occlusive disease and thirty-two generally healthy control subjects were enrolled in this study. Polymerase chain reaction (PCR) was used to identify Porphyromonas gingivalis, Treponema denticola, Actinobacillus actinomycetemcomitans, Prevotella intermedia, Cytomegalovirus (CMV), Chlamydia pneumoniae, and Helicobacter pylori in tissue specimens taken from the anastomotic site of distal bypasses. Periodontal status was evaluated; serum IgG titres against the four listed bacteria were measured.
Results. Periodontopathic bacteria were detected in 13/25 (52%) atherosclerotic specimens. CMV or C. pneumoniae was detected in 1125 (4%) specimens; H. pylori was not detected from any of these specimens. Fontaine grade III or IV patients showed higher detection frequency of P. gingivalis than Fontaine grade II patients (57.1% vs 22.2%, P = 0.09). After adjusting for age, gender, diabetes and smoking, periodontitis increased 5-fold the risk of having PAD (OR 5.45). There were preliminary indications that periodontitis was associated with increased serum IL-6 and TNF-alpha concentrations.
Conclusions. This study suggests that periodontitis may be associated with an increased risk of PAD. This association could result from the increased concentration of serum inflammatory cytokines in those with periodontitis. (c) 2007 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.

Web of Science ® 被引用回数 : 76

リンク情報
DOI
https://doi.org/10.1016/j.ejvs.2007.08.016
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000253380400005&DestApp=WOS_CPL

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