MISC

2009年10月

Association between periodontitis and anti-cardiolipin antibodies in Buerger disease

JOURNAL OF CLINICAL PERIODONTOLOGY
  • Yi-Wen Chen
  • ,
  • Toshiyuki Nagasawa
  • ,
  • Nawarat Wara-Aswapati
  • ,
  • Yuka Ushida
  • ,
  • Dongqing Wang
  • ,
  • Yasuo Takeuchi
  • ,
  • Hiroaki Kobayashi
  • ,
  • Makoto Umeda
  • ,
  • Yoshinori Inoue
  • ,
  • Takehisa Iwai
  • ,
  • Isao Ishikawa
  • ,
  • Yuichi Izumi

36
10
開始ページ
830
終了ページ
835
記述言語
英語
掲載種別
DOI
10.1111/j.1600-051X.2009.01467.x
出版者・発行元
WILEY-BLACKWELL PUBLISHING, INC

P>Aim
Anti-cardiolipin (CL) antibodies can be induced in Buerger disease (BD), an inflammatory occlusive disorder affecting peripheral blood vessels, in response to bacteria bearing homology to the TLRVYK peptide of a phospholipid-binding plasma protein beta-2-glycoprotein I. TLRVYK homologies are present in Porphyromonas gingivalis (TLRIYT) and Treponema denticola (TLALYK). This study investigated the association between periodontal infection and anti-CL antibodies in BD patients.
Material and Methods
Periodontal conditions were examined in 19 BD patients and 25 systemically healthy control subjects. All subjects were heavy smokers. Serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies were assessed using the enzyme-linked immunosorbent assay.
Results
BD patients had a significantly higher prevalence of periodontitis, more severe periodontal destruction and increased titres of serum anti-CL, anti-TLRVYK, anti-TLRIYT, and anti-TLALYK antibodies compared with healthy subjects. The levels of anti-CL antibodies positively correlated with those of the three anti-peptide antibodies. Anti-CL antibody titres were significantly associated with the percentage of sites with clinical attachment level >= 4 mm in BD patients.
Conclusion
Elevated anti-CL antibody levels were associated with periodontal destruction in BD patients. Periodontopathic bacteria may serve as exogenous antigens that stimulate the anti-CL antibody production through molecular mimicry between the bacterial peptides and a host plasma protein.

Web of Science ® 被引用回数 : 26

リンク情報
DOI
https://doi.org/10.1111/j.1600-051X.2009.01467.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000269728700003&DestApp=WOS_CPL

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