We describe a case of HIV infection in a patient with oral symptoms.<BR>A 55-year-old man visited the Department of Dentistry and Oral Surgery, Tokyo Metropolitan Hiroo General Hospital on October 24, 1998. because of discomfort in the tongue and oropharynx. The patient had white patches on the hard and soft palates and a hairy white lesion on the both borders of the tongue on initial oral examination. Clinically, oral candidiasis and hairy leukoplakia were suspected. On clinical examination, the CD 4 was 4.7%, the CD 4/CD 8 cell ratio was 0.10, and the Epstein-Barr virus antibody titer was 640 fold. HIV antibody was positive on both particle agglutination analysis and Western blot analysis. He received antimycosal drugs for candidiasis and was treated with AZT, 3 TC, and NFV for HIV infection at the department of internal medicine of our hospital. After 1 year, oral examination revealed no signs of oropharyngeal candidiasis or hairy leukoplakia on the borders of the tongue.