MISC

2003年3月

Oral pseudotumor - Benign polypoid masses following radiation therapy

CANCER
  • S Oota
  • ,
  • H Shibuya
  • ,
  • M Hamagaki
  • ,
  • R Yoshimura
  • ,
  • H Iwaki
  • ,
  • M Kojima
  • ,
  • M Takagi

97
5
開始ページ
1353
終了ページ
1357
記述言語
英語
掲載種別
DOI
10.1002/cncr.11164
出版者・発行元
JOHN WILEY & SONS INC

BACKGROUND. The current study evaluated postirradiation pseudotumor in the oral cavity to investigate clinical and pathologic characteristics and incidence rates.
METHODS. Between 1960 and 1999, 2719 patients with squamous cell carcinoma of the oral cavity were treated with radiation therapy at Tokyo Medical and Dental University Hospital. Of these, six patients developed clinically polypoid tumors pathologically diagnosed as pseudoturnors. Histopathology, immunohistology, and the clinical courses of these lesions were investigated.
RESULTS. Spindled fibroblastic cells arranged in whorled patterns were common pathologic features. Immunohistochemical results showed reactivity for vimentin and smooth muscle actin and nonreactivity for cytokeratin. The latent period from the initial radiation therapy to the development of the pseudotumor ranged from 45 to 145 months (median, 79 months). The overall cumulative incidence of pseudotumor was 0.22% during the 40 year period. All six patients were cured with simple excisions.
CONCLUSIONS. oral carcinoma patients treated with radiation therapy may develop pseudotumor in a low frequency with a shorter period than that of radiation induced carcinoma/sarcoma. Pseudotumor was curable with surgery. Pseudotumor should be added to the list of differential diagnosis for postirradiation oral polypoid masses. (C) 2003 American Cancer Society.

Web of Science ® 被引用回数 : 14

リンク情報
DOI
https://doi.org/10.1002/cncr.11164
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000181190000028&DestApp=WOS_CPL

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