北嶋繁孝 (Shigetaka Kitajima) - マイポータル - researchmap

基本情報

所属: 東京医科歯科大学難治疾患研究所ゲノム応用医学研究部門ゲノム応用医学研究部門教授

学位: 医学博士

J-GLOBAL ID: 200901019684521340
researchmap会員ID: 1000014688

研究キーワード

2

研究分野

1

ライフサイエンス / 医化学 /

MISC

50

Identification and biochemical characterization of a novel transcription elongation factor, Elongin A3

K Yamazaki, LM Guo, K Sugahara, C Zhang, H Enzan, Y Nakabeppu, S Kitajima, T Aso

JOURNAL OF BIOLOGICAL CHEMISTRY 277(29) 26444-26451 2002年7月
Cell-cycle-dependent regulation of human aurora a transcription is mediated by periodic repression of E4TF1

M Tanaka, A Ueda, H Kanamori, H Ideguchi, J Yang, S Kitajima, Y Ishigatsubo

JOURNAL OF BIOLOGICAL CHEMISTRY 277(12) 10719-10726 2002年3月
Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53.

Biochem. Biophys. Res. Commun. 297:1302-1310 2002年
Transcriptional repressor ATF3 protects human umbilical vein endothelial cells from TNF-a-induced apoptosis through down-regulation of p53 transcription.

J. Biol. Chem. 277:39025-39034 2002年
ATF3 Inhibits Doxorubicin-induced Apoptosis in Cardiac Myocytes: A Novel Cardioprotective Role of ATF3.

J. Mol. Cell. Cardiol. 34:1387-1397 2002年
Expression of cyclin D1 and CDK4 causes hypertrophic growth of cardiomyocytes in cuture: a possible implication for cardiac hypertrophy.

Biochem. Biophys. Res. Commun. 296:274-280 2002年
An alternatively spliced isoform of transcriptional repressor ATF3 and its induction by stress stimuli.

Nucleic Acids Res. 30:2398-2406 2002年
Expression of transcriptional repressor ATF3/LRF1 in human atherosclerosis: colocalization and functional involvement in cell death of vascular endothelial cells.

Atherosclerosis 161:281-291 2002年
Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine

C Zhang, J Kawauchi, MT Adachi, Y Hashimoto, S Oshiro, T Aso, S Kitajima

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 289(3) 718-724 2001年12月
Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response.

J. Biol. Chem. 276:35867-35874 2001年
Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity

T Aso, K Yamazaki, T Aigaki, S Kitajima

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 276(1) 355-361 2000年9月
Repression of TNF-alpha-induced E-selectin expression by PPAR activators: Involvement of transcriptional repressor LRF-1/ATF3

T Nawa, MT Nawa, Y Cai, C Zhang, Uchimura, I, S Narumi, F Numano, S Kitajima

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 275(2) 406-411 2000年8月
Homocysteine-responsiae ATF3 gene expression in human vascular endothelial cells : activation of c-Jun NH₂-terminal Kinase and promoter response element.

Blood 96:2140-2148 2000年
Identification and characterization of elongin A2, a new member of an elongin family of transcription elongation factors, specifically expressed in the testis.

J. Biol. Chem. 275:6546-6552 2000年
Metabolic fate of oxidized ribonucleotides in mammalian cells.

Biochemistry 38:3610-3614 1999年
Evolution of the HIV-1 LTR promoter by conversion of an NF-kB enhancer element into a GABP binding site.

J. Virol. 73:1331-1340 1999年
Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family.

J. Biol. Chem. 273:20721-20727 1998年
Mechanism of transciption by RNA polymerase (]G0002[)-a molecular basis of regulated gene expression.

J. Med. & Dent. Sciences 45: 59-67 1998年
Characterization of the human thrombopoietin gene promoter: A possible role of an Ets transcription factor, E4TF1/GABP

Takumi Kamura, Hiroshi Handa, Naotaka Hamasaki, Shigetaka Kitajima

Journal of Biological Chemistry 272(17) 11361-11368 1997年4月25日
Phosphorylation of human general transcription factors TATA-binding protein and IIB by DNA-dependent protein kinase: Synergistic stimulation of RNA polymerase II basal transcription in vitro.

Eur. J. Biochem. 247:1166-1173 1997年

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所属学協会

9

共同研究・競争的資金等の研究課題

4