江口正 (EGUCHI TADASHI) - マイポータル

基本情報

所属: 東京工業大学 (名誉教授)

学位: 理学博士(東京工業大学)

研究者番号: 60201365
J-GLOBAL ID: 200901094836808749
researchmap会員ID: 1000015915

学歴

- 1980年

横浜市立大学, 文理学部, 化学

論文

Functional Characterization of 3‐Aminobenzoic Acid Adenylation Enzyme PctU and UDP‐ N ‐Acetyl‐ d ‐Glucosamine: 3‐Aminobenzoyl‐ACP Glycosyltransferase PctL in Pactamycin Biosynthesis

Fumitaka Kudo, Jiahao Zhang, Shusuke Sato, Akane Hirayama, Tadashi Eguchi

ChemBioChem 2019年10月査読有り
Structural Analysis of the Glycine Oxidase Homologue CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis

Daisuke Kawasaki, Taichi Chisuga, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi

Biochemistry 58(24) 2706-2709 2019年6月査読有り
An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

Fumihiro Ishikawa, Akimasa Miyanaga, Hinano Kitayama, Shinya Nakamura, Isao Nakanishi, Fumitaka Kudo, Tadashi Eguchi, Genzoh Tanabe

Angewandte Chemie International Edition 58(21) 6906-6910 2019年5月査読有り
An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

Fumihiro Ishikawa, Akimasa Miyanaga, Hinano Kitayama, Shinya Nakamura, Isao Nakanishi, Fumitaka Kudo, Tadashi Eguchi, Genzoh Tanabe

Angewandte Chemie 131(21) 6980 2019年5月査読有り
Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

Jolanta Cie{\'{s } }lak, Akimasa Miyanaga, Makoto Takaishi, Fumitaka Kudo, Tadashi Eguchi

Acta Crystallographica Section F Structural Biology Communications 75(4) 299 2019年4月査読有り
Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, Su L, Yang M, Gao C, Yao Y …

PLoS biology 17(5) e3000252 2019年査読有り
Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

Fumitaka Kudo, Akimasa Miyanaga, Tadashi Eguchi

Journal of Industrial Microbiology & Biotechnology 46(3-4) 515 2018年10月査読有り
Biochemical and Structural Analysis of FomD That Catalyzes the Hydrolysis of Cytidylyl (S)-2-Hydroxypropylphosphonate in Fosfomycin Biosynthesis

Shusuke Sato, Akimasa Miyanaga, Seung-Young Kim, Tomohisa Kuzuyama, Fumitaka Kudo, Tadashi Eguchi

Biochemistry 2018年8月査読有り
C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration

Shusuke Sato, Fumitaka Kudo, Tomohisa Kuzuyama, Friedrich Hammerschmidt, Tadashi Eguchi

Biochemistry 2018年8月査読有り
Structural Basis of Protein–Protein Interactions between a trans-Acting Acyltransferase and Acyl Carrier Protein in Polyketide Disorazole Biosynthesis

Akimasa Miyanaga, Risako Ouchi, Fumihiro Ishikawa, Ena Goto, Genzoh Tanabe, Fumitaka Kudo, Tadashi Eguchi

Journal of the American Chemical Society 140(25) 7970-7978 2018年6月27日査読有り
NAD+-Dependent Dehydrogenase PctP and Pyridoxal 5′-Phosphate Dependent Aminotransferase PctC Catalyze the First Postglycosylation Modification of the Sugar Intermediate in Pactamycin Biosynthesis

Akane Hirayama, Jinmiao Chu, Ena Goto, Fumitaka Kudo, Tadashi Eguchi

ChemBioChem 19(2) 126-130 2018年1月18日査読有り
Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

Natural Product Reports 2018年査読有り
Carbon-free production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus PCC 7942

Satoru Watanabe, Hiroaki Ozawa, Hiroaki Kato, Kaori Nimura-Matsune, Toshifumi Hirayama, Fumitaka Kudo, Tadashi Eguchi, Katsumi Kakinuma, Hirofumi Yoshikawa

Bioscience, Biotechnology and Biochemistry 82(1) 161-165 2018年査読有り
Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis

Akimasa Miyanaga, Ryuichi Takayanagi, Takashi Furuya, Ayano Kawamata, Tomohiro Itagaki, Yoshiharu Iwabuchi, Naoki Kanoh, Fumitaka Kudo, Tadashi Eguchi

CHEMBIOCHEM 18(21) 2179-2187 2017年11月査読有り
Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme

Su-Hee Cho, Seung-Young Kim, Takeo Tomita, Taro Shiraishi, Jin-Soo Park, Shusuke Sato, Fumitaka Kudo, Tadashi Eguchi, Nobutaka Funa, Makoto Nishiyama …

ACS CHEMICAL BIOLOGY 12(8) 2209-2215 2017年8月査読有り
Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis

Shusuke Sato, Fumitaka Kudo, Seung-Young Kim, Tomohisa Kuzuyama, Tadashi Eguchi

BIOCHEMISTRY 56(28) 3519-3522 2017年7月査読有り
Biochemical characterization and structural insight into aliphatic -amino acid adenylation enzymes IdnL1 and CmiS6

Jolanta Cieslak, Akimasa Miyanaga, Ryoma Takaku, Makoto Takaishi, Keita Amagai, Fumitaka Kudo, Tadashi Eguchi

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 85(7) 1238-1247 2017年7月査読有り
Structural analysis of the dual-function thioesterase SAV606 unravels the mechanism of Michael addition of glycine to an alpha,beta-unsaturated thioester

Taichi Chisuga, Akimasa Miyanaga, Fumitaka Kudo, Tadashi Eguchi

JOURNAL OF BIOLOGICAL CHEMISTRY 292(26) 10926-10937 2017年6月査読有り
Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host

Keita Amagai, Haruo Ikeda, Junko Hashimoto, Ikuko Kozone, Miho Izumikawa, Fumitaka Kudo, Tadashi Eguchi, Takemichi Nakamura, Hiroyuki Osada, Shunji Takahashi …

SCIENTIFIC REPORTS 7 2017年6月査読有り
Substrate specificity of radical S-adenosyl-L-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3 '-deoxygenation of aminoglycoside antibiotics

Fumitaka Kudo, Takahiro Tokumitsu, Tadashi Eguchi

JOURNAL OF ANTIBIOTICS 70(4) 423-428 2017年4月査読有り

もっとみる

MISC

213

Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891: Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation

Fumitaka Kudo, Atsushi Motegi, Kazutoshi Mizoue, Tadashi Eguchi

CHEMBIOCHEM 11(11) 1574-1582 2010年7月
Roles of a 20 kDa Protein Associated with a Carbocycle-Forming Enzyme Involved in Aminoglycoside Biosynthesis in Primary and Secondary Metabolism

Hideyuki Tamegai, Hiroshi Sawada, Eriko Nango, Rie Aoki, Haruka Hirakawa, Teruhiko Iino, Tadashi Eguchi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 74(6) 1215-1219 2010年6月
Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster

Fumitaka Kudo, Hilda Sucipto, Tadashi Eguchi

JOURNAL OF ANTIBIOTICS 62(12) 707-710 2009年12月
Crystal structure of 3-isopropylmalate dehydrogenase in complex with NAD(+) and a designed inhibitor

Eriko Nango, Takashi Yamamoto, Takashi Kumasaka, Tadashi Eguchi

BIOORGANIC & MEDICINAL CHEMISTRY 17(22) 7789-7794 2009年11月
Enzymatic preparation of neomycin C from ribostamycin

Fumitaka Kudo, Taiki Kawashima, Kenichi Yokoyama, Tadashi Eguchi

JOURNAL OF ANTIBIOTICS 62(11) 643-646 2009年11月
Biosynthetic genes for aminoglycoside antibiotics

Fumitaka Kudo, Tadashi Eguchi

JOURNAL OF ANTIBIOTICS 62(9) 471-481 2009年9月
The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells

Susumu Inaba, Tadashi Eguchi, Atsushi Motegi, Kazutoshi Mizoue, Takeo Usui, Kazuo Nagai, Takao Kataoka

JOURNAL OF ANTIBIOTICS 62(9) 507-512 2009年9月
BIOSYNTHETIC ENZYMES FOR THE AMINOGLYCOSIDES BUTIROSIN AND NEOMYCIN

Fumitaka Kudo, Tadashi Eguchi

COMPLEX ENZYMES IN MICROBIAL NATURAL PRODUCT BIOSYNTHESIS, PART B: POLYKETIDES, AMINOCOUMARINS AND CARBOHYDRATES 459 493-519 2009年
Biosynthetic Genes for Aminoglycoside Antibiotics

Fumitaka Kudo, Tadashi Eguchi

J. Antibiot. 62(9) 471-481 2009年
Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy

Kenichi Yokoyama, Daijiro Ohmori, Fumitaka Kudo, Tadashi Eguchi

BIOCHEMISTRY 47(34) 8950-8960 2008年8月
Biosynthetic pathway of 24-membered macrolactam glycoside incednine

Makoto Takaishi, Fumitaka Kudo, Tadashi Eguchi

TETRAHEDRON 64(28) 6651-6656 2008年7月
Crystallization and preliminary X-ray analysis of vicenisaminyltransferase VinC

Eriko Nango, Atsushi Minami, Takashi Kumasaka, Tadashi Eguchi

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 64(6) 558-560 2008年6月
Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae

Ying Lin, Jerome Volkman, Kenneth M. Nicholas, Takashi Yamamoto, Tadashi Eguchi, Susan L. Nimmo, Ann H. West, Paul F. Cook

BIOCHEMISTRY 47(13) 4169-4180 2008年4月
Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis

Kenichi Yokoyama, Yasuhito Yamamoto, Fumitaka Kudo, Tadashi Eguchi

CHEMBIOCHEM 9(6) 865-869 2008年4月
Thiahomoisocitrate: A highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway

Takashi Yamamoto, Tadashi Eguchi

BIOORGANIC & MEDICINAL CHEMISTRY 16(6) 3372-3376 2008年3月
Thiahomoisocitrate: A Highly Potent Inhibitor of Homoisocitrate Dehydrogenase Involved in the α-Aminoadipate Pathway

Takashi Yamamoto, Tadashi Eguchi

Bioorg. Med. Chem. 16(6) 3372-3376 2008年3月
Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD(+)

Eriko Nango, Takashi Kumasaka, Toshifumi Hirayama, Nobuo Tanaka, Tadashi Eguchi

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 70(2) 517-527 2008年2月
Crystallization and preliminary X-ray analysis of vicenisaminyltransferase VinC

Eriko Nango, Atsushi Minami, Takashi Kumasaka, Tadashi Eguchi

Acta Crystallographica Section F: Structural Biology and Crystallization Communications 64(6) 558-560 2008年
糖質環化酵素の構造と機能の解明竏茶oイオマスから化学工業資源へ竏驤

南後恵理子, 江口正

バイオサイエンスとインダストリー 66(2) 61-64 2008年
Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin

Kenichi Yokoyama, Mario Numakura, Fumitaka Kudo, Daijiro Ohmori, Tadashi Eguchi

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(49) 15147-15155 2007年12月

もっとみる

書籍等出版物

化学実験セーフティーガイド

化学同人 2006年
D-Glucose: Extremely versatile Resource for Organic Synthesis

My Favorite Organic Synthesis, The Society of Synthetic Organic Chemistry, Japan 2002年
D-Glucose: Extremely versatile Resource for Organic Synthesis

My Favorite Organic Synthesis, The Society of Synthetic Organic Chemistry, Japan 2002年
Membrane Properties of Archaeal Phospholipids: Effect of Macrocyclization

Giant Vesicles 1999年
Membrane Properties of Archaeal Phospholipids: Effect of Macrocyclization

Giant Vesicles 1999年
創薬化学の基礎となる先導物質の合成法（共著）

廣川書店 1996年

江口正

基本情報

学歴

論文

MISC

書籍等出版物

所属学協会

メニュー