J-GLOBAL         Last updated: Nov 15, 2018 at 23:21
Tokyo Institute of Technology
Job title
Professor Emeritus
Doctor of Science

Research Areas


Academic & Professional Experience



Graduate School, Division of Science, The University of Tokyo

Awards & Honors

Jun 2010
The Gregor Johann Mendel Honorary Medal for Merit in the Biological Sciences, The Academy of Sciences of the Czech Republic
The 10th Prince Hitachi Prize for Comparative Oncology

Published Papers

Kishimoto T
Proceedings of the Japan Academy. Series B, Physical and biological sciences   94(4) 180-203   Apr 2018   [Refereed][Invited]
Takeda N, Kon Y, Quiroga Artigas G, Lapébie P, Barreau C, Koizumi O, Kishimoto T, Tachibana K, Houliston E, Deguchi R
Development (Cambridge, England)   145(2)    Jan 2018   [Refereed]
Hiraoka D, Aono R, Hanada S, Okumura E, Kishimoto T
Journal of cell science   129(16) 3153-3166   Aug 2016   [Refereed]
Kubiak JZ, Kishimoto T
The International journal of developmental biology   60(7-8-9) 193-200   2016   [Refereed][Invited]
Kishimoto T
Chromosoma   124(4) 417-428   Dec 2015   [Refereed][Invited]
Okumura E, Morita A, Wakai M, Mochida S, Hara M, Kishimoto T
The Journal of cell biology   204(6) 881-889   Mar 2014   [Refereed]
Ucar H, Tachibana K, Kishimoto T
Journal of cell science   126(Pt 22) 5153-5165   Nov 2013   [Refereed]
Wada T, Hara M, Taneda T, Qingfu C, Takata R, Moro K, Takeda K, Kishimoto T, Handa H
Nucleic acids research   40(22) e173   Dec 2012   [Refereed]
Hara M, Abe Y, Tanaka T, Yamamoto T, Okumura E, Kishimoto T
Nature communications   3 1059   2012   [Refereed]
Kishimoto T
Molecular reproduction and development   78(10-11) 704-707   Oct 2011   [Refereed][Invited]
Hiraoka, D., Okumura, E. and Kishimoto, T.
Oncogene   30 4487-4497   May 2011   [Refereed]
Gotoh T, Kishimoto T, Sible JC
Developmental biology   353(2) 302-308   May 2011   [Refereed]
Morita M, Hamao K, Izumi S, Okumura E, Tanaka K, Kishimoto T, Hosoya H
Journal of biochemistry   148(5) 533-538   Nov 2010   [Refereed]
Abe Y, Okumura E, Hosoya T, Hirota T, Kishimoto T
Journal of cell science   123(Pt 22) 3978-3988   Nov 2010   [Refereed]
Tachibana K, Mori M, Matsuhira T, Karino T, Inagaki T, Nagayama A, Nishiyama A, Hara M, Kishimoto T
Proceedings of the National Academy of Sciences of the United States of America   107(11) 5006-5011   Mar 2010   [Refereed]
Hara M, Mori M, Wada T, Tachibana K, Kishimoto T
Development (Cambridge, England)   136(10) 1687-1696   May 2009   [Refereed]
Tachibana K, Hara M, Hattori Y, Kishimoto T
Current biology : CB   18(17) 1308-1313   Sep 2008   [Refereed]
Gotoh T, Shigemoto N, Kishimoto T
Developmental biology   310(2) 341-347   Oct 2007   [Refereed]
Tomoko Nishiyama, Keita Ohsumi, Takeo Kishimoto
Nature   446(7139) 1096-1099   2007
Tomoko Nishiyama, Norio Yoshizaki, Takeo Kishimoto, Keita Ohsumi
Nature   449(7160) 341-345   2007
Nishiyama, A. Muraki, K. Saito, M. Ohsumi, K. Kishimoto, T. Ishikawa, F.
EMBO J.   25(3) 575-584   2006
Mori, M. Hara, M. Tachibana, K. Kishimoto, T.
Development   133(9) 1823-1830   2006
Yamamoto, T.M. Iwabuchi, M. Ohsumi, K. Kishimoto, T.
Dev. Biol.   279(2) 345-355   2005
In memory of Andre Picard: 1950-2004 (Obituary).
Kishimoto, T.
Biol. Cell   97 349-350   2005   [Invited]
Keishi Shintomi, Mari Iwabuchi, Hideaki Saeki, Kiyoe Ura, Takeo Kishimoto, Keita Ohsumi
Proc. Natl. Acad. Sci. USA   102(23) 8210-8215   2005
Kishimoto, T.
Nature   437 963-965   2005   [Invited]
Biol. Cell   96 241-244   2004   [Refereed][Invited]
Ohsumi, K. Koyanagi, A. Yamamoto, T.M. Gotoh, T. Kishimoto, T.
Proc. Natl. Acad. Sci. USA   101(34) 12531-12536   2004
Uchida, A. Tashiro, T. Komiya, Y. Yorifuji, H. Kishimoto, T. Hisanaga, S.
J. Neurochem.   88(3) 735-745   2004
Hiraoka, D. Hori-Oshima, S. Fukuhara, T. Tachibana, K Okumura, E. Kishimoto, T.
Dev. Biol.   276(2) 330-336   2004
Developmental regulation of the proteolysis of the p35 cyclin-dependent kinase 5 activator by phosphorylation.
Saito, T. Onuki, R. Fujita, Y. Kusakawa, G. Ishiguro, K. Bibb. J. A. Kishimoto, T. Hisanaga s.
J. Neurosci.   23 1189-1197   2003
Honma, N. Asada, A. Takeshita, S. Enomoto, M. Yamakawa, E. Tsutsumi, K. Saito, T. Satoh, T. Itoh, H. Kaziro, Y. Kishimoto, T. Hisanaga, S.
Biochem. Biophys. Res. Comm.   310(2) 398-404   2003
Okano-Uchida, T. Okumura, E. Iwashita, M. Yoshida, H. Tachibana, K. Kishimoto, T.
EMBO J.   22(20) 5633-5642   2003
Terasaki, M. Okumura, E. Hinkel, B. Kishimoto, T.
Mol. Biol. Cell   14 4685-4694   2003
Kishimoto, T.
Curr. Opin. Cell Biol.   15 654-663   2003   [Refereed][Invited]
Okumura, E. Fukuhara, T. Yoshida, H. Hanada, S. Kozutsumi, R. Mori, M. Tachibana, K. Kishimoto, T.
Nature Cell Biol.   4 111-116   2002
Iwabuchi, M. Ohsumi, K. Yamamoto, T. M. Kishimoto, T.
Dev. Biol   243(1) 34-43   2002
Kuramoto, M., Ohsumi, K., Kishimoto, T. and Ishikawa, F.
Gene   277 101-110   2001   [Refereed]
Inactivation of the checkpoint kinase Cds1 is dependent on cyclin B-Cdc2 kinase activation at the meiotic G2/M-phase transition in Xenopus oocytes.
Gotoh, T. Ohsumi, K. Matsui, T. Takisawa, H. Kishimoto, T.
J. Cell Sci.   114 3397-3406   2001
Misaki, K. Mukai, H. Yoshinaga, C. Oishi, K. Isagawa, T. Takahashi, M. Ohsumi, K. Kishimoto, T. Ono, Y.
Proc. Natl. Acad. Sci. USA   98(1) 125-129   2001
Uchida, A. Komiya, Y. Tashiro, T. Yorifuji, H. Kishimoto, T. Nabeshima, Y. Hisanaga, S.
J. Neurosci. Res.   364-370   2001
Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary culture of embryo rat cortical neurons
Tokuoka, H., Saito, T., Yorifuji, H., Wei, F-Y., Kishimoto, T. and Hisanaga, S.
J. Cell Sci.   113 1059-1068   2000   [Refereed]
Kitazawa, H., Iida, J., Uchida, A., Haino-Fukushima, K., Itoh, T.J., Hotani, H., Ookata, K., Murofushi, H., Bulinski, J.C., Kishimoto, T. and Hisanaga, S.
Cell Struc. Funct.   25 33-39   2000   [Refereed]
Iwabuchi, M. Ohsumi, K. Yamamoto, T. M. Sawada, W. Kishimoto, T.
EMBO J.   19(17) 4513-4523   2000
Tachibana, K. Tanaka, D. Isobe, T. Kishimoto, T.
Proc. Natl. Acad. Sci. U.S.A.   97(26) 14301-14306   2000
Nishiyama, A. Tachibana, K. Igarashi, Y. Yasuda, H. Tanahashi, N. Tanaka, K. Ohsumi, K. Kishimoto
Genes Dev.   14(18) 2344-2357   2000
Kusakawa, G. Saito, T. Onuki, R. Ishiguro, K. Kishimoto, T. Hisanaga, S.
J. Biol. Chem.   275(22) 17166-17172   2000
Kawahara, H. Kasahara, M. Nishiyama, A. Ohsumi, K. Goto, T. Kishimoto, T. Saeki, Y. Yokosama, H. Shimbara, N. Murata, S. Chiba, T. Suzuki, K. Tanaka
EMBO J.   19(15) 4144-4153   2000
Developmental Biology   214(1) 1-8   1999
Seminars Cell Develop. Biol.   9(5) 549-557   1998
Initial Triggering of M-Phase in Starfish Oocytes:A Possible Novel Component of MPF Besides cdc2 Kinase
J.Cell Biol   132 125-135   1996
Trends Biochemical Sciences   21(1) 35-37   1996
Isolation and characterization of the cDNA for an A-like cyclin in Adiantum capillus-veneris L.
Plant and Cell Physiology   37 825-832   1996
Evidence for cdk5 as a major activity phosphorylating tau protein in porcine brain extract.
J. Biochem.   117 741-749   1995
Degradation of c-Fos by the 26S Proteasome is Accelerated by c-Jun and Multiple Protein Kinases
Mol.Cell.Biol.,   (15) 5682-5687   1995
Cell reproduction : induction of M-phase events by cyclin-dependent cdc2 kinase.
Int. J. Dev. Biol.   38 185-191   1994
Meiosis-specific cell cycle regulation in maturing ┣DBXenopus(/)-┫DB oocytes.
J. Cell Sci.   107 3005-3013   1994
Microtubule nucleating activity of centrosomes in cell-free extracts from Xenopus eggs : involvement of phosphorylation and accumulation of pericentriolar material.
Journal of Cell Science   (104) 124-137   1993
Tau protein kinase II has a similar characteristic to cdc 2 kinase for phosphorylating neurofilament proteins.
Journal of Biological Chemistry   (268) 15056-15060   1993
Association of p34┣D1cdc2┫D1/cyclin B complex with microtubules in starfish oocytes.
Journal of Cell Science   (105) 873-881   1993
Biochemistry Biophysics Research Communication   195(2) 837-843   1993
Science   262(5142) 2033-2035   1993
Relocation and distinct subcellular localization of p34┣D1cdc2┫D1-cyclin B complex at meiosis reinitiation in starfish oocytes.
EMBO Journal   11   1992
P13┣D1suc1┫D1 suppresses the catalytic function of p34┣D1dc2┫D1 kinase for intermediate filament proteins, in vitro.
Journal of Biological Chemistry   (267) 20937-20942   1992
Phosphorylation of neurofilament H subunit at the tail comain by CDC2 kinase dissociates the association to microtubules.
Journal of Biological Chemistry   266   1991
Developmental Biology   133   1989
Development Growth and Differentiation   30(2) 105-115   1988
Preliminary characterization of maturation-promoting factor from yeast ┣DBSaccharomyces(/)-┫DB ┣DBcerevisiae(/)-┫DB.
Journal of Cell Science   88   1987


Cell Cycle Control by Cyclin-Dependent Klnases
27(8) 316-319   1995
Cell cycle
Biological Science   (44) 425-442-445   1993

Books etc

Methods in Mol. Biol., vol. 1128, “Developmental Biology of the Sea Urchin and other Marine Invertebrates” (Carroll, D. and Stricker, S.A., eds.)
Okumura, E., Hara, M., and Kishimoto, T. (Part:Contributor, Antibody inhibition of protein activity in starfish oocytes (Chap. 21, pp. 311-330))
Springer Science+Business Media, New York   2014   
Oogenesis: The Universal Process (Verlhac, M.H. and Villeneuve, A., eds.)
Nishiyama, T., Tachibana, K., and Kishimoto, T. (Part:Contributor, Cytostatic arrest: Post-ovulation arrest until fertilization in metazoan oocytes (Chap. 14, pp. 357-384))
Wiley-Blackwell, UK   2010   
Cell Division and the Replicon : Human Frontier Workshop IX (Fangman, W.L., Kishimoto, T., Kohiyama, M. and Coath, C., eds)
Kishimoto, T. (Part:Joint Editor, Meiotic cell-cycle control (pp.140-145))
Human Frontier Science Program, Strasbourg   2000   
Cell Division and the Replicon : Human Frontier Workshop IX
Human Frontier Science Program   2000   
Oocyte maturation and spawning in starfish.
Encyclopedia of Reproduction (Knobil, E. and Neill, J. D. eds.)   1999   
In vivo Regulation of the entry into M-phase : initial activation and nuclear translocation of cyclin B/Cdc2.
Progress in Cell Cycle Res. (Meijer, L. , Guidet, S. and Philippe, M. eds. ), Plenum Press, New York   1997   
The Cell Cycle -an Introduction
Control of M-phase by MPF/cyclin-dependent cdc2 kinase.
Japan Scientific Societies PressBiology of Germ Line-In Animals andMan(共著)   1993   
Oocyte maturation and cdc2 kinase.
MPF・cdc2 kinases・cyclin-Regulation of M-phase and cell cycle-
Hormonal control of oocyte maturation in Echinoderms. (共著)
Wiley-Liss Progress in clinical and Biological Research.   1990   

Research Grants & Projects

cell reproduction control
oocyte maturation and early development
M-phase control