2006年2月
The amino-terminal residue of glycoprotein B is critical for neutralization of bovine herpesvirus 1
VIRUS RESEARCH
- ,
- ,
- ,
- 巻
- 115
- 号
- 2
- 開始ページ
- 105
- 終了ページ
- 111
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.virusres.2005.07.008
- 出版者・発行元
- ELSEVIER SCIENCE BV
In order to address the neutralization epitope on bovine herpesvirus 1 (BHV 1) glycoprotein B (gB), a panel of monoclonal antibodies (MAbs), a series of truncation forms of the glycoprotein and an MAb-escape mutant were used in this study. Immunocytochemistry on the truncations using MAbs against the glycoprotein revealed that the neutralization epitopes recognized by the MAbs lay between residues 1 and 52 of mature gB. Comparison of the sequences among the mutant, parent, and revertant viruses demonstrated that the amino-terminal residue of mature gB of the escape mutant was changed from Arg to Gln. These findings indicate that the amino-terminal residue of gB is critical for neutralization of BHV1. (c) 2005 Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.virusres.2005.07.008
- ISSN : 0168-1702
- PubMed ID : 16153736
- Web of Science ID : WOS:000235051300001