2014年4月
An NA-deficient 2009 pandemic H1N1 influenza virus mutant can efficiently replicate in cultured cells
ARCHIVES OF VIROLOGY
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- 巻
- 159
- 号
- 4
- 開始ページ
- 797
- 終了ページ
- 800
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00705-013-1887-0
- 出版者・発行元
- SPRINGER WIEN
We identified a novel neuraminidase (NA)-deficient virus that was a 2009 pandemic influenza H1N1 virus mutant. The mutant virus had a deletion of 1,009 nt in the NA gene and lacked an enzymatic domain. Although the yield of the NA-deficient virus was limited, it formed large plaques when applied to MDCK cell cultures, indicating that the virus was able to spread to adjacent cells. Furthermore, the NA-deficient virus was eluted from chicken erythrocytes at 37 A degrees C, even in the presence of the antiviral drug peramivir. Spread of this NA-deficient virus may pose a potential threat to anti-influenza therapies.
- リンク情報
- ID情報
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- DOI : 10.1007/s00705-013-1887-0
- ISSN : 0304-8608
- eISSN : 1432-8798
- PubMed ID : 24142272
- Web of Science ID : WOS:000334055200020