2002年5月
Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 17
- 号
- 3
- 開始ページ
- 144
- 終了ページ
- 149
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s00384-001-0372-5
- 出版者・発行元
- SPRINGER-VERLAG
Background and aims: Serrated adenoma (SA) is a newly defined category of colorectal neoplasia that contains features of both adenoma and hyperplastic polyp, and has two patterns, hyperplastic and cerebriform patterns. Since cyclooxygenase 2 (COX-2) has been found upregulated in colorectal cancers and adenomas, we examined whether either the hyperplastic or cerebriform pattern of SA has the potential for tumor progression and should be a target for clinical treatment. Patients and methods: An immunohistochemical scoring system was used to compare COX-2 expression in colorectal SAs (n=79), tubular adenomas (n=66), and hyperplastic polyps (n=21). Results: COX-2 scores were significantly higher in SA of the cerebriform pattern (n=44) than in SA of the hyperplastic pattern (n=35). There was no difference in COX-2 scores between SA of the cerebriform pattern and tubular adenoma. In SA accompanied by hyperplastic polyp (n=26) the hyperplastic components expressed little COX-2, the same as traditional hyperplastic polyps. COX-2 expression in the SA component was similar to that in pure SA. Conclusion: SA of the cerebriform pattern should be treated similarly as traditional tubular adenomas. COX-2 induction may additionally be involved in progression from hyperplastic polyp to SA.
- リンク情報
- ID情報
-
- DOI : 10.1007/s00384-001-0372-5
- ISSN : 0179-1958
- Web of Science ID : WOS:000175153000004