論文

査読有り
2005年10月

Development of the articular cavity in the rat temporomandibular joint with special reference to the behavior of endothelial cells and macrophages

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY
  • A Suzuki
  • ,
  • K Nozawa-Inoue
  • ,
  • N Ikeda
  • ,
  • N Amizuka
  • ,
  • K Ono
  • ,
  • R Takagi
  • ,
  • T Maeda

286A
2
開始ページ
908
終了ページ
916
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/ar.a.20228
出版者・発行元
WILEY-LISS

Previous developmental studies on the temporomandibular joint (TMJ) have proposed several hypotheses on the formation of its articular cavity. However, detailed information is meager. The present study examined the formation process of the articular cavity in the rat TMJ by immunocytochemistry for CD31, RECA-1, and ED1, which are useful cellular markers for endothelial cells and monocyte/macrophage lineages, respectively. The upper articular cavity formation had begun by embryonic day 21 (E21) and was completed at postnatal day 1 (P1) in advance of the lower cavitation; the latter took place from P1 to P3. The occurrence and distribution pattern of the CD31-, RECA-1-, and ED1-positive cells differed between the upper and lower articular cavity-forming areas: the ED1-positive cells exclusively occurred in the area of the prospective upper articular cavity prior to its formation, while no ED1-positive cell appeared in the lower cavity-forming area. In contrast, the CD31- and RECA-1-positive endothelial cells were restricted to the lower cavity-forming area (never the prospective upper cavity) at E19 and diminished thereafter. Throughout the cavity formation, we failed to find any apoptotic cells in the cavity formation area, indicating no involvement of apoptosis in the cavity formation in TMJ. The present findings on the behaviors of endothelial cells and ED1-positive cells show a possibility of different mechanism in the cavity formation between the upper and lower articular cavities in the rat TMJ. The appearance of ED1-reactive cells and temporal vascularization may play crucial roles in the upper and lower articular cavity formation, respectively. (C) 2005 Wiley-Liss, Inc.

リンク情報
DOI
https://doi.org/10.1002/ar.a.20228
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16110516
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000232431000005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/ar.a.20228
  • ISSN : 1552-4884
  • PubMed ID : 16110516
  • Web of Science ID : WOS:000232431000005

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