Purpose: This six-clinic collaborative study collected patient opinions after orthodontic treatment, for quality improvement. Materials and methods: Participants comprised 477 patients with unilateral cleft lip and palate (UCLP) who had undergone orthodontic treatment at orthodontic clinics in five university hospitals and one private office in Japan. The questionnaire sent to patients contained 33 questions in five categories, about the respondent, before, during and after orthodontic treatment, and overall treatment. Questionnaires were returned by mail anonymously. Results: Responses were received from 183 patients (response rate, 38.4%). Patients tended to anticipate esthetic improvements in anterior teeth and facial appearance, and reported great improvements with orthodontic treatment. Masticatory problems also improved and orthodontic treatment had positive effects on speech. Almost all respondents were satisfied with orthodontic treatment. Problems with overall treatment were long treatment period, difficulty attending clinics and maintenance of oral hygiene during treatment. Conclusion: This study clarified the subjective effects and problems with orthodontic treatment in patients with UCLP in Japan. Satisfaction after treatment was high. Anticipated esthetic improvement was accomplished and masticatory problems improved. Orthodontic treatment also positively affected speech. Efficient orthodontic treatment to minimize treatment duration and improved treatment systems for easier access are needed to reduce patient burdens in Japan.