2002年5月
Intrathecal administration of 5-HT3 receptor agonist modulates jaw muscle activity evoked by injection of mustard oil into the temporomandibular joint in the rat
BRAIN RESEARCH
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- 巻
- 934
- 号
- 2
- 開始ページ
- 157
- 終了ページ
- 161
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0006-8993(02)02367-3
- 出版者・発行元
- ELSEVIER SCIENCE BV
The effect of intrathecal administration of the 5-HT3 receptor agonist 2-methyl-5-hydroxytryptamine (2m-5HT) on jaw muscle activity evoked by mustard oil (MO) injection into the temporomandibular joint of anesthetized rats was examined. One microgram or 100 mug of 2m-5HT significantly enhanced or suppressed jaw muscle responses, respectively. Pre-administration of tropisetron, a 5-HT3 receptor antagonist, attenuated the effect of 2m-5HT. These results indicate that activation of 5-HT, receptors can modulate trigeminal nociceptive responses. (C) 2002 Elsevier Science B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0006-8993(02)02367-3
- ISSN : 0006-8993
- eISSN : 1872-6240
- PubMed ID : 11955479
- Web of Science ID : WOS:000175897600009