論文

査読有り 筆頭著者 責任著者
2002年5月

Intrathecal administration of 5-HT3 receptor agonist modulates jaw muscle activity evoked by injection of mustard oil into the temporomandibular joint in the rat

BRAIN RESEARCH
  • K Seo
  • ,
  • N Fujiwara
  • ,
  • JW Hu
  • ,
  • BE Cairns
  • ,
  • G Someya

934
2
開始ページ
157
終了ページ
161
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/S0006-8993(02)02367-3
出版者・発行元
ELSEVIER SCIENCE BV

The effect of intrathecal administration of the 5-HT3 receptor agonist 2-methyl-5-hydroxytryptamine (2m-5HT) on jaw muscle activity evoked by mustard oil (MO) injection into the temporomandibular joint of anesthetized rats was examined. One microgram or 100 mug of 2m-5HT significantly enhanced or suppressed jaw muscle responses, respectively. Pre-administration of tropisetron, a 5-HT3 receptor antagonist, attenuated the effect of 2m-5HT. These results indicate that activation of 5-HT, receptors can modulate trigeminal nociceptive responses. (C) 2002 Elsevier Science B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/S0006-8993(02)02367-3
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11955479
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000175897600009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/S0006-8993(02)02367-3
  • ISSN : 0006-8993
  • eISSN : 1872-6240
  • PubMed ID : 11955479
  • Web of Science ID : WOS:000175897600009

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