MISC

2007年8月

Leptin modulates the response to oleic acid in the pharynx

NEUROSCIENCE LETTERS
  • Junichi Kitagawa
  • ,
  • Tomio Shingai
  • ,
  • Yuka Kajii
  • ,
  • Yoshihiro Takahashi
  • ,
  • Yo Taguchi
  • ,
  • Shigeji Matsumoto

423
2
開始ページ
109
終了ページ
112
記述言語
英語
掲載種別
DOI
10.1016/j.neulet.2007.06.040
出版者・発行元
ELSEVIER IRELAND LTD

Leptin released from the adipose tissues is known to inhibit obesity by regulating food intake. In this study, we investigated the effect of leptin on afferent nerve responses to fats and fatty acid in the pharyngolaryngeal region. The afferent nerve activities were recorded from the whole nerve bundle or pauci-fiber bundles of the pharyngeal branch of the glossopharyngeal nerve (GPN-ph) in Wistar normal and fatty rats. Oleic acid (long-chain fatty acid), mineral oil (nonfat oil) and safflower oil (vegetable oil; middle-chain fatty acid) were applied to the surface of pharyngolaryngeal mucous membrane. Oleic acid elicited vigorous Stimulation of the GPN-ph activity in both normal and fatty rats but other oils had no significant effect on the activity. After intravenous administration of leptin (30 ng/kg, 1 ml), the response to oleic acid was significantly decreased in normal rats, whereas such a decrease was not found in fatty rats. These results are the first findings to indicate the existence of a suppressive mechanism of leptin on the response of the GPN-ph to fatty acid in normal rats, but that such a mechanism is lacking in fatty rats. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2007.06.040
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000249491200005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neulet.2007.06.040
  • ISSN : 0304-3940
  • Web of Science ID : WOS:000249491200005

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