MISC

2006年9月

Nitric oxide modulates elicitation of reflex swallowing from the pharynx in rats

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
  • Hiroshi Kijima
  • ,
  • Tomio Shingai
  • ,
  • Yoshihiro Takahashi
  • ,
  • Yuka Kajii
  • ,
  • Shin-ichi Fukushima
  • ,
  • Yo Taguchi
  • ,
  • Tadashi Noda
  • ,
  • Yoshiaki Yamada

291
3
開始ページ
R651
終了ページ
R656
記述言語
英語
掲載種別
DOI
10.1152/ajpregu.00646.2005
出版者・発行元
AMER PHYSIOLOGICAL SOC

The pharynx is very important for elicitation of reflex swallowing. The region of the pharynx is innervated by the pharyngeal branch of the glossopharyngeal nerve (GPN-ph). Nitric oxide ( NO) plays an important role in various physiological functions. The purpose of this study is to investigate the contribution of NO to reflex swallowing evoked by electrical stimulation of the GPN-ph. Swallowing was evoked in urethane-anesthetized rats by application of repetitive electrical stimulation ( 10- to 20-mu A amplitude, 10- to 20-Hz frequency, 1.0-ms duration) to the central cut end of the GPN-ph or superior laryngeal nerve. Swallowing was identified by electromyographic activity of the mylohyoid muscle. Latency to the first swallow and the interval between swallows were measured. Intravenous administration of N-G-nitro-L-arginine ( L- NNA, 0.6 mg/ kg), a nonselective inhibitor of NO synthase ( NOS), extremely prolonged latency to the first swallow and the interval between swallows evoked by the GPN-ph. Intraperitoneal administration of 7-nitroindazole (5.0 mg/ kg), a selective inhibitor of neuronal NOS, significantly prolonged latency to the first swallow and the interval between swallows evoked by the GPN-ph. Administration of L- arginine ( an NO donor, 500 mg/ kg) and sodium nitroprusside ( an NO releaser, 0.6 mg/ kg) restored the suppression of swallowing induced by the NOS inhibitor. Superior laryngeal nerve-evoked swallowing was suppressed by administration of a higher dose of L- NNA (6.0 mg/ kg). Swallowing evoked by water stimulation of the pharynx was also suppressed by L- NNA ( 0.6 mg/ kg). These results suggest that NO plays an important role in signal processing for initiation of reflex swallowing from the pharynx.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1152/ajpregu.00646.2005
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000239658800022&DestApp=WOS_CPL
ID情報
  • DOI : 10.1152/ajpregu.00646.2005
  • ISSN : 0363-6119
  • Web of Science ID : WOS:000239658800022

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