SHIBA Kazuhiro

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Name
SHIBA Kazuhiro
Affiliation
Kanazawa University
Section
Advanced Science Research Center, Advanced Science Research Center

Research Areas

 
 

Academic & Professional Experience

 
2014
 - 
Today
Advanced Science Research center, Kanazawa University
 
1980
 - 
1999
: Kanazawa University 
 
1993
 - 
1995
: Kanazawa University 
 
1999
 - 
2003
: Kanazawa University 
 
2003
 - 
2009
: Kanazawa University 
 

Education

 
 
 - 
1980
Faculty of Pharmaceutical Science, Kanazawa University
 

Published Papers

 
Development of a novel radiobromine-labeled sigma-1 receptor imaging probe.
Kazuma Ogawa, Ryohei Masuda, Yoshiaki Mizuno, Akira Makino, Takashi Kozaka, Yoji Kitamura, Yasushi Kiyono, Kazuhiro Shiba, and Akira Odani.
Nuclear Medicine and Biology.   61 28-35   Jun 2018   [Refereed]
In vivo and in vitro characteristics of radiolabeled vesamicol analogs as the Vesicular Acetylcholine Transporter (VAChT) imaging agents.
Kazuma Ogawa, Kazuhiro Shiba.
Contrast Media & Molecular Imaging.   2018(4535476) 1-14   Jun 2018   [Refereed][Invited]
Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFRβ) imaging probes.
Nurmaya Effendi, Kenji Mishiro, Takeshi Takarada, Akira Makino, Daisuke Yamada, Yoji Kitamura, Kazuhiro Shiba, Yasushi Kiyono, Akira Odani, and Kazuma Ogawa
Scientific Reports   8(1) 10369   Jun 2018   [Refereed]
Quantification of Myocardial Perfusion Defect Size in Rats: Comparison between Quantitative Perfusion SPECT and Autoradiography.
H. Wakabayashi, J. Taki, A, Inaki, T. Hiromasa, K. Okuda, T. Shibutani, K. Shiba, S. Kinuya.
Molecular Imaging & Biology,   DOI10.1007/s11307-018-1159-1.    Jan 2018   [Refereed]
Comparison of radioiodine- or radiobromine-labeled RGD peptides between direct and indirect labeling methods.
Kazuma Ogawa, Takuya Takeda, Masaru Yokokawa, Jing Yu, Akira Makino, Yasushi Kiyono, Kazuhiro Shiba, Seigo Kinuya, and Akira Odani.
Chem Pharm Bull.   66(6) 651-659   2018   [Refereed]
Evaluation of Ga-DOTA-(D-Asp)n as bone imaging agents: D-aspartic acid peptides as carriers to bone.
K. Ogawa, A. Ishizaki, K. Takai, Y. Kitamura, A. Makino, T. Kozaka, Y. Kiyono, K. Shiba, A. Odani.
Sci Rep,   25(7) 13971   Oct 2017   [Refereed]
Kazuma Ogawa, Ryohei Matsuda, Kazuhiro Shiba.
Bunseki kagaku   66(6) 403-411   Jun 2017   [Refereed]
N. Effendi, K. Ogawa, K. Mishiro, T. Takarada, D. Yamada, Y. Kitamura, K. Shiba, T. Maeda, A. Odani.
Bioorg Med Chem   25 5576-5585   2017   [Refereed]
Kobayashi M, Matsunari I, Nishi K, Mizutani A, Miyazaki Y, Ogai K, Sugama J, Shiba K, Kawai K, Kinuya S.
Ann Nucl Med   30 263-271   May 2016   [Refereed]
Kazuma Ogawa, Tadahisa Fukuda, Jaegab Han, Yoji Kitamura, Kazuhiro Shiba, and Akira Odani.
PLoS One   doi: 10.1371/journal.pone.0148    Feb 2016   [Refereed]
Izumi Uno, Takashi Kozaka, Daisuke Miwa, Yoji Kitamura, Azim Mohammad Anwar-ul, Kazuma Ogawa, Junichi Taki, Seigo Kinuya and Kazuhiro Shiba.
PLOS ONE   11(1) DOI:10.1371/journal.pone.01467   Jan 2016   [Refereed]
Yoji Kitamura, Takashi Kozaka, Daisuke Miwa, Izumi Uno, Mohammad Anwar-ul Azim, Kazuma Ogawa, Junichi Taki, Seigo Kinuya and Kazuhiro Shiba.
Ann. Nucl. Med.   30 122-129   2016   [Refereed]
Hiroshi Wakabayashi, Junichi Taki, Anri Inaki, Kazuhiro Shiba, Ichiro Matsunari and Seigo Kinuya.
EJNMMI Research   DOI 10.1186/s13550-015-0152-9.    Dec 2015   [Refereed]
Taki J, Inaki A, Wakabayashi H, Matsunari I, Imada-Yoshida K, Ogawa K, Hiroe M, Shiba K, Yoshida T, Kinuya S.
EJNMMI RESEARCH,   DOI: 10.1186/s13550-015-0100-8    Apr 2015   [Refereed]
Kazuma Ogawa, Jing Yu, Atsushi Ishizaki, Masaru Yokokawa, Masanori Kitamura, Yoji Kitamura, Kazuhiro Shiba, and Akira Odani.
Bioconjugate.Chem.   26(8) 1561-1570   2015   [Refereed]
Ogawa K, Mizuno Y, Washiyama K, Shiba, K, Takahashi N, Kozaka T, Shinohara A, Odani A
Nucl. Med. Biol.   42(11) 875-879   2015   [Refereed]
Syntheses and In-vitro Evaluation of Tetrahydroaminoacridine (THA) Based Analogues as High Affinity Choline Transporter (HAChT) Imaging Probe.
Mohammad Anwar Ul Azim, Takashi Kozaka, Izumi Uno, Daisuke Miwa, Yoji Kitamura, Kazuma Ogawa, Kazuhiro Shiba.
Bangladesh J. Nuclear Med.   17(2) 97-102   Jul 2014   [Refereed]
Lopatina O, Yoshihara T, Nishimura T, Zhong J, Akther S, Fakhrul AA, Liang M, Higashida C, Sumi K, Furuhara K, Inahata Y, Huang JJ, Koizumi K, Yokoyama S, Tsuji T, Petugina Y, Sumarokov A, Salmina AB, Hashida K, Kitao Y, Hori O, Asano M, Kitamura Y, Kozaka T, Shiba K, Zhong F, Xie MJ, Sato M, Ishihara K, Higashida H.
Front Behav Neurosci.   doi: 10.3389/fnbeh.2014.00133.    Apr 2014   [Refereed]
Takashi Kozaka, Izumi Uno, Yoji Kitamura, Daisuke Miwa, Mohammad Anwar-ul Azim, Kazuma Ogawa, Kazuhiro Shiba.
Synapse.   68 107-113   Mar 2014   [Refereed]
Mohammad Anwar-ul Azima, Takashi Kozakaa, Izumi Unoa, Daisuke Miwaa, Yoji Kitamuraa, Kazuma Ogawa, Akira Makino, Yasushi Kiyono, Kazuhiro Shiba
Synapse   68 445-453   2014   [Refereed]
Kazuma Ogawa, Katsuichi Ohtsuki, Tomomi Shibata, Miho Aoki, Morio Nakayama, Yoji Kitamura, Masahiro Ono, Masashi Ueda, Tomoki Doue, Masahisa Onoguchi, Kazuhiro Shiba, Akira Odani.
PLoS One.   DOI: 10.1371/journal.pone.0084    Dec 2013   [Refereed]
Ogawa K, Ishizuka A, Takai K, Kitamura Y, Kiwada T, Shiba K, Odani A.
PLoS One.   DOI: 10.1371/journal.pone.0084    Dec 2013   [Refereed]
Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Kikuo Shimizu, Kazuyoshi Masumoto, Masahiro Hirota, Shogo Higaki, Hirokazu Miyoshi, Takuya Saze, Minoru Sakama, Makoto Yanaga.
Radiation Measurement.   55 26-29   Aug 2013   [Refereed]
Junichi Taki, Hiroshi Wakabayashi, Anri Inaki, Kyoko Imanaka-Yoshida, Michiaki Hiroe, Kazuma Ogawa, Miyako Morooka, Kazuo Kubota, Kazuhiro Shiba, Toshimichi Yoshida and Seigo KInuya
J. Nucl. Med.   54(3) 431-436   Mar 2013   [Refereed]
Report regarding radioactivity removal from contaminated vegetables derived from the Fukushima nuclear accident.
SHIBA Kazuhiro
Radiation Safety Management.   12(1) 31-36   2013   [Refereed]
Kazuma Ogawa, Hiroya Kanbara, Yasushi Kiyono, Yoji Kitamura, Tatsuto Kiwada, Takashi Kozaka, Masanori Kitamura, Tetsuya Mori, Kazuhiro Shiba,
Nucl. Med. Biol.   40(4) 445-450   2013   [Refereed]
Takashi Kozaka, Izumi Uno, Yoji Kitamura, Daisuke Miwa, Kazuma Ogawa, Kazuhiro Shiba.
Bioorganic & Medicinal Chemistry   20(16) 4936-4941   Aug 2012   [Refereed]
Sugihara T., Munesue S., Yamamoto Y., Sakurai S., Akhter N., Kitamura Y., Shiba K, et al.
Journal of Alzheimer's Disease,   28(3) 709-720   Jan 2012   [Refereed]
Chemical removal of radionuclides in contaminated spinach derived from the Fukushima nuclear accident.
Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Hirokazu Miyoshi, Makoto Yanaga,
Radiation Safety Management.   11(1) 19-22   2012   [Refereed]
Characteristics of radioactive contamination of vegetables derived from the Fukushima nuclear accident.
Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Izumi Uno, Kikuo Shimizu, Masahiro Hirota, Shogo Higaki, Kazuyoshi Masumoto.
Radiation Safety Management.   11(1) 23-26   2012   [Refereed]
Kazuma Ogawa, Hiroya Kanbara, Kazuhiro Shiba, Yoji Kitamura, Takashi Kozaka, Tatsuto Kiwada and Akira Odani.
EJNMMI Research.   2 54-63   2012   [Refereed]
Ogawa K., Takai K., Kanbara H., Kiwada T., Kitamura Y., Shiba K,et al.,
Nuclear Medicine and Biology   38(5) 631-636   May 2011   [Refereed]
Taki, J., Inaki A., Wakabayashi, H., Imanaka-Yoshida, K., Ogawa, K., Hiroe, M., Shiba, K., Yoshida, T., Kinuya, S.
J. Nucl. Med   51 1116-1122   2010   [Refereed]
K. Ogawa, H. Kawashima, S. Kinuya, K. Shiba, M. Onoguchi, H. Kimura, K. Hashimoto, A. Odani, H. Saj
Annals of Nuclear Medicine   23 843-848   Nov 2009   [Refereed]
K. Ogawa, K. Shiba, N. Akhter, M. Yoshimoto, K. Washiyama, S. Kinuya, K. Kawai, and H. Mori
Cancer Science   100(11) 2188-2192   Jul 2009   [Refereed]
Development of 90Y-DOTA conjugated bisphosphonate for treatment of painful bone metastases
NUCLEAR MEDICINE AND BIOLOGY   29,434-440    2009
In vivo Characterization of Radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol [(+)-pIV] as a potential sigma-1 receptor imaging agent.
NUCLEAR MEDICINE AND BIOLOGY   34(6) 697-702   2007
Therapeutic effects for the palliation of metastatic bone pain of a rhenium-186 complex-conjugated bisphosphonate in an animal model.
JOURNAL OF NUCLEAR MEDICINE   48(1) 122-127   2007
JOURNAL OF NEUROSCIENCE METHODS   157,98-102    2006
KINUYA Seigo, BAI Jingming, SHIBA Kazuhiro, YOKOYAMA Kunihiko, MORI Hirofumi, FUKUOKA Makoto, WATANABE Naoto, SHUKE Noriyuki, MICHIGISHI Takatoshi, TONAMI Norihisa
ANNALS OF NUCLEAR MEDICINE   20(1) 29-34   2006
Changes of Tc-99m Sestanibi uptake in P-glycoprotein expressing Leukaemia Cells Treated in vivo with Antisense Oligodeoxynucleotide Complementary to mdr1 mRNA.
World J. Nucl. Med.   5(2) 115-118   2006
Locoreginal radioimmunotherapy with 186Re-labeled monoclonal antibody in treating small peritoneal carcinomatosis of colon cancer in mice in comparison with 131I-counterpart.
CANCER LETTERS   219 41-48   2005
Anti-angiogenic therapy and chemotherapy affect 99mTc-sestamibi and 99mTc-HL91 accumulation differentially in tumour xenografts.
NUCLEAR MEDICINE COMMUNICATIONS   21(1067-1073)    2005
EUROPEAN JOURNAL OF NUCLEAR MEDICINE   31(11) 1523-1529   2004
NUCLEAR MEDICINE COMMUNICATIONS   25(49-53)    2004
Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy
EUROPEAN JOURNAL OF NUCLEAR MEDICINE   31(7) 981-985   2004
Evaluation of Radioiodinated (-)-o-iodovesamicol as a radiotracer for mapping the vesicular acetylcholine transporter.
ANNALS OF NUCLEAR MEDICINE   17(6) 451-456   2003
KINUYA S, LI X‐F, YOKOYAMA K, MORI H, SHIBA K, WATANABE N, SHUKE N, BUNKO H, MICHIGISHI T
Cancer Science   94(7) 650-654   2003
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   129 392-396   2003
EUROPEAN JOURNAL OF NUCLEAR MEDICINE   30(9) 1246-1250   2003
Reduction of 99mTc-sestamibi and 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE   30(11) 1529-1531   2003
Reduction of vesicular acetylcholine transporter in B-amyloid protein infused rats with memory impairment
NUCLEAR MEDICINE COMMUNICATIONS   21 933-937   2000
Retrograde transport of nerve growth factor from olfactory bulb to olfactory epithelium
NEUROREPORT   9 153-155   1998
SHIBA K, MORI H, ICHIKAWA A, TONAMI N
LIFE SCIENCES   59(13) 1039-1045   1996
Radioiodinated (-)-2-[4-(3-iodophenyl)piperidino]cyclohexanol: A Potential Radioligand for Mapping Presynaptic Cholinergic Neurons.
NUCLEAR MEDICINE COMMUNICATIONS   17 485-492   1996
Atypicality of Several Antipsychotics on The Basis of In Vivo Dopamine-D2 and Serotonin-5HT2 Receptor Occupancy.
T. Sumiyosi, K. Suzuki, H. Sakamoto, N. Yamaguchi, H. Mori, K. Shiba and K. Yokogawa.
Neuropsychopharmacology   12 57-64   1995   [Refereed]
Synthesis of Radioiodinated Analogs of 2-(4-phenylpiperidino)cyclohexanol(Vesamicol) as Vesamicol-like Agent.
K. Shiba, H. Mori, H. Matsuda, S. Tsuji, H. Sumiya, K. Kinuya, N. Tonami, K. Hisada and T. Sumiyosi
Nucl. Med. Biol.   22 205-210   1995   [Refereed]
Dual-tracer autoradiography using 125I-iomazanil and 99mTc-HMPAO in experimental brain ischaemia.
H. Matsuda, S. Tsuji, I. Kuji, K. Shiba, K. Hisada and H. Mori
Nucl. Med. Commun.   16 581-590   1995   [Refereed]
In vivo Characterization of Radioiodinated 2-(4-Phenylpiperidino) cyclohexanol (Vesamicol) Analogs: Potential Radioligand for Mapping Presynaptic Cholinergic Neurones
K. Shiba, H. Mori, H. Matsuda, S. Tsuji, N. Tonami and K. Hisada.
Nucl. Med. Biol.   22 823-828   1995   [Refereed]
In Vivo Dopamine-D2 and Serotonin-5HT2 Receptor Binding Study of Risperidone and Haloperidol.
T. Sumiyosi, H. Kido, H. Sakamoto, K. Urasaki, K. Suzuki, N. Yamaguchi, H. Mori, K. Shiba and K. Yokogawa
Pharmacolgy Biochemistry and Behavior.   47(3) 553-557   1994   [Refereed]
Time course of Dopamine1,2 and Serotonin 2 Receptor Binding of Antipsychotics In Vivo.
T. Sumiyosi, H. Kido, H. Sakamoto, K. Urasaki, K. Suzuki, N. Yamaguchi, H. Mori and K. Shiba.:
Pharmacolgy Biochemistry and Behavior   49 165-169   1994   [Refereed]
Time course of Dopamine-D2 and Serotonin-5HT2 receptor occupancy rates by Haloperidol and Clozapine in vivo.
T. Sumiyosi, H. Kido, H. Sakamoto, K. Urasaki, K. Suzuki, N. Yamaguchi, H. Mori, K. Shiba, K. Yokogawa and F. Ichimura.
J. Psychi. Neurology   47 131-137   1993   [Refereed]
Technetium-99m p-Iodophenethyl diaminodithiol (DADT-IPE): Potential Brain Perfusion Lmaging Agent for SPECT.
K. Shiba, H. Mori, H. Matsuda and K. Hisada
Nucl. Med. Biol.   19 303-310   1992   [Refereed]
Synthesis of Technetium-99m labeled diaminodithiol for bifunctional chelating agents.
K. Shiba, H. Mori, H. Matsuda, S. Tsuji, K. Kinuya and K. Hisada.
Appl. Radiat. Isot.   42 1159-1164   1991   [Refereed]
Synthesis and characterization of 99mTc-p-halophenethyl diaminodithiol analogs.
K. Shiba, H. Mori, H. Matsuda and K. Hisada
Nucl. Med. Commun.   12 1057-1067   1991   [Refereed]
Characteristics of the binding of N-isopropyl-p-[125I]iodoamphetamine in the rat brain synaptosomal membranes.
H. Mori, K. Shiba, H. Matsuda, S. Tsuji and K. Hisada
Nucl. Med. Commun   11 327-331   1990   [Refereed]
Autoradiographic analysis of iodoamphetamine redistribution in experimental brain ischemia.
H. Matsuda, S. Tsuji, H. Oba, K. Shiba, H. Terada, K. Kinuya, H. Mori, H. Sumiya and K. Hisada
J. Nucl. Med.   31 660-667   1990   [Refereed]
Analogues of α-aminoisobutyric acid with various alkyl groups as potential tumour imaging agents; effects of chain length on tumour and normal tissue specificity.
K. Shiba, H. Mori and K. Hisada.
Nucl. Med. Commun.   10 751-758   1989   [Refereed]
Duble tracer autoradiographic evaluation of regional cerebral perfusion.
H. Matsuda, S. Tsuji, H. Oba, K. Kinuya, H. Terada, H. Sumiya, K. Shiba, H. Mori and K. Hisada
Am J. Physiol. Imaging.   4 131-135   1989   [Refereed]
Direct autoradiographic comparison of 99mTc-HMPAO with 125I-IMP in experimental brain ischemia.
H. Matsuda, S. Tsuji, H. Oba, K. Imai, K. Shiba, H. Terada, H. Seki, H. Sumiya, H. Mori and K. Hisada
Nucl. Med. Commun   9 891-897   1988   [Refereed]
Determination of flow and rate constants in a kinetic model of [99mTc]-Hexamethyl-propylene amine oxime in the human brain.
H. Matsuda, H. Oba, H. Seki, S. Higashi, H. Sumiya, S. Tsuji, H. Terada, K. Imai, K. Shiba, H. Mori and K. Hisada
J. Cereb. Blood Flow. Metabol.   8 S61-S68   1988   [Refereed]
Quantitative assessment of cerebral blood flow using Technetium-99m-hexamethylene amine oxime: part I, design of a mathematical model
H. Matsuda, H. Oba, H. Terada, S. Tsuji, H. Sumiya, K. Shiba, H. Seki, K. Imai, H. Mori and K. Hisada
Annal. Nucl. Med.   2 13-19   1988   [Refereed]
Binding sites and subcelluar distribution of N-isopropyl-p-(I-125)Iodoamphetamine in the rat brain.
S. Tsuji, H. Mori, K. Shiba, H. Matsuda and K. Hisada
J. Cereb. Blood Flow Metabol.   7 544   1987   [Refereed]

Misc

 
Self-radiolysis of tritiated thymidine. Radioisotopes.
46,622-626    1997

Works

 
The development of a PET tracer for cerebral function analysis
2002

Research Grants & Projects

 
Study on Syntheses of Radiopharmaceutical for cerebral nerve function diagnosis
Project Year: 1999   
Development of a high sensitive evaluation of internal radiation exposure
Project Year: 2001