SHOSAKU TAKAKO

Profile Information

Affiliation: Professor, Faculty of Health and Medical Sciences , Hokuriku University

Degree: 医学博士(京都大学)
医科学修士(大阪大学)

Other name(s) (e.g. nickname): OHNO-SHOSAKU TAKAKO
Researcher number: 60179025
J-GLOBAL ID: 200901019119070288
researchmap Member ID: 1000019710

External link: http://yoneda-lab.w3.kanazawa-u.ac.jp/index.html

Research Interests

Research Areas

Research History

Apr, 2023 - Present

Professor, Faculty of Health and Medical Sciences, Hokuriku University
Apr, 2005 - Mar, 2022

Faculty of Health Sciences, Kanazawa University
Dec, 1996 - Mar, 2005

Graduate School of Medical Science, Kanazawa University
Jul, 1994 - Nov, 1996

Faculty of Medicine, Kanazawa University
Apr, 1991 - Jun, 1994

Faculty of Medicine, Kanazawa University
Apr, 1987 - Mar, 1991

Department of Physiology, Osaka Medical College
Apr, 1985 - Jul, 1986

Faculty of Medicine, Kyoto University

Education

Apr, 1981 - Mar, 1985

Graduate School, Division of Medicine, Kyoto University
Apr, 1979 - Mar, 1981

Osaka University
Apr, 1975 - Mar, 1979

Kanazawa University

Committee Memberships

2007

-: Physiol. Soc. Japan
2007

常任幹事, 日本生理学会

Papers

Action sequence learning is impaired in genetically modified mice with the suppressed GABAergic transmission from the thalamic reticular nucleus to the thalamus

Takako Ohno-Shosaku, Mitsugu Yoneda, Takashi Maejima, Mohan Wang, Yui Kikuchi, Kaito Onodera, Yuji Kanazawa, Chitoshi Takayama, Michihiro Mieda

Neuroscience, Sep, 2023
Evaluation of motor learning in predictable loading task using a force sense presentation device

Tetsuo Ota, Yui Kikuchi, Ikumi Amiya, Takako Ohno-Shosaku, Yasuharu Koike, Mitsugu Yoneda

Experimental Brain Research, 240(12) 3305-3314, Dec, 2022
Effects of environmental enrichment on exploratory behavior, win-stay and lose-shift performance, motor sequence learning, and reversal learning during the three-lever operant task in mice.

Yui Kikuchi, Mitsugu Yoneda, Kyoko Nishikawa, Tsukika Noda, Honoka Hasegawa, Tomoaki Fujisaku, Takako Ohno-Shosaku

Behavioural brain research, 429 113904-113904, Jul 5, 2022
Effects of long-term treatment with dietary theobromine on rat skeletal muscles.

Shoji Tanaka, Naotoshi Sugimoto, Takako Ohno-Shosaku, Sachiko Madokoro, Pleiades Tiharu Inaoka, Toshiaki Yamazaki

Molecular biology reports, 49(5) 3965-3973, May, 2022
Endocannabinoid Signaling from 2-Arachidonoylglycerol to CB1 Cannabinoid Receptor Facilitates Reward-based Learning of Motor Sequence

Hayate Tanigami, Mitsugu Yoneda, Yuki Tabata, Ryosuke Echigo, Yui Kikuchi, Maya Yamazaki, Yasushi Kishimoto, Kenji Sakimura, Masanobu Kano, Takako Ohno-Shosaku

Neuroscience, 421 1-16, Nov, 2019 Peer-reviewed
Corticosterone inhibits the expression of cannabinoid receptor-1 and cannabinoid receptor agonist-induced decrease in cell viability in glioblastoma cells.

Sugimoto N, Ishibashi H, Ueda Y, Nakamura H, Yachie A, Ohno-Shosaku T

Oncology letters, 18(2) 1557-1563, Aug, 2019 Peer-reviewed
Hypoxia-induced inhibition of the endocannabinoid system in glioblastoma cells

Naotoshi Sugimoto, Hiroaki Ishibashi, Hiroyuki Nakamura, Akihiro Yachie, Takako Ohno-Shosaku

ONCOLOGY REPORTS, 38(6) 3702-3708, Dec, 2017 Peer-reviewed
Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signaling.

Fukudome Y, Ohno-Shosaku T, Matsui M, Omori Y, Watanabe M, Kano M

Eur J Nuerosci., 19(10) 2682-2692, 2017 Peer-reviewed
Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice

Mitsugu Yoneda, Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Hayate Tanigami, Akihiro Yachie, Takako Ohno-Shosaku, Osamu Shido

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 39 110-116, Jan, 2017
Relationship between prediction-based motor control during loading task and motor learning during lever-pressing task

Ota T, Yoneda M, Kikuchi Y, Ohno-Shosaku T

J Wellness Health Care, 41(1) 37-48, 2017 Peer-reviewed
The relationship between probabilistic selection task and motor prediction during a loading task

40(1) 97-101, Jul 29, 2016
Electrophysiological evidence showing muscarinic agonist antagonist activities of N-desmethylclozapine using hippocampal excitatory and inhibitory neurons

Yuto Sugawara, Yui Kikuchi, Mitsugu Yoneda, Takako Ohno-Shosaku

BRAIN RESEARCH, 1642 255-262, Jul, 2016
Test-retest reliability for the measures of the probabilistic selection task modified for Japanese subjects

35(3) 289-300, Jun, 2016
Correspondence between acceleration waveform and electromyogram in the task for feed-forward motor control

19(1) 31-35, 2016
若年成人におけるProbabilistic Selection Task成績の性差の検討

米田貢, 寺嶋翔子, 高林亮, 岡本涼子, 菊池ゆひ, 少作隆子

日本作業療法研究学会雑誌, 19(1) 7-14, 2016
Availability of three-lever operant task as mouse model for studying motor sequence and skill learning.

Yoneda M, Tabata Y, Echigo R, Kikuchi Y, Ohno-Shosaku T

Tsuruma Health Sci Soc Kanazawa Univ, 39(2) 113-122, Jan, 2016
フィードバックの感覚モダリティの違いがProbabilistic Selection Taskの学習に与える影響

米田貢, 寺嶋翔子, 太田哲生, 菊池ゆひ, 少作隆子

日本作業療法研究学会雑誌, 19(2), 2016
Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy (vol 16, pg 264, 2015)

Ivan Soltesz, Bradley E. Alger, Masanobu Kano, Sang-Hun Lee, David M. Lovinger, Takako Ohno-Shosaku, Masahiko Watanabe

NATURE REVIEWS NEUROSCIENCE, 16(6) 264-277, Jun, 2015
Endocannabinoid-mediated retrograde modulation of synaptic transmission

Takako Ohno-Shosaku, Masanobu Kano

CURRENT OPINION IN NEUROBIOLOGY, 29 1-8, Dec, 2014
Impaired anticipatory hand movement during a loading task in patients with schizophrenia

KikuchiY, YonedaM, Ohno-ShosakuT

J Tsuruma Health Sci Soc, 38(1) 21-28, 2014 Peer-reviewed

Misc.

Theobromine, the primary methylxanthine found in Theobroma cacao, can pass through the blood-brain barrier in mice

Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Takako Ohno-Shosaku, Akihiro Yachie, Osamu Shido

FASEB JOURNAL, 30, Apr, 2016
Cannabinoids prevent TLR2-induced inflammation via CB1 receptor in human glioblastoma cells

Ryousuke Echigo, Naotoshi Sugimoto, Akihiro Yachie, Takako Ohno-Shosaku

NEUROSCIENCE RESEARCH, 71 E197-E197, 2011
N-desmethylclozapine, a metabolite of the antipsychotic clozapine, modulates excitatory and inhibitory signals oppositely by acting on M1 muscarinic and GABA(A) receptors in hippocampal neurons

Yuto Sugawara, Chiho Muranishi, Keisuke Nagasawa, Takako Ohno-Shosaku

NEUROSCIENCE RESEARCH, 71 E298-E299, 2011
Comparison of the performance on three-lever operant task between control and Parkinson's model rats

Ryoko Watanabe, Mitsugu Yoneda, Yui Kikuchi, Takako Ohno-Shosaku

NEUROSCIENCE RESEARCH, 71 E140-E140, 2011
Molecular mechanisms for the induction of retrograde endocannabinoid signaling

Yuki Hashimotodani, Takako Ohno-Shosaku, Asami Tanimura, Masanobu Kano

JOURNAL OF PHYSIOLOGICAL SCIENCES, 60 S47-S47, 2010
MODULATION OF HIPPOCAMPAL INHIBITORY SYNAPTIC TRANSMISSION THROUGH PROTEASE-ACTIVATED RECEPTOR 1

Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kano

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 146-146, 2009
Mechanisms of endocannabinoid release and retrograde synaptic suppression in the CNS

Masanobu Kano, Yuki Hashimotodani, Takako Ohno-Shosaku, Takashi Maejima

NEUROSCIENCE RESEARCH, 58 S10-S10, 2007
Roles of monoacylglycerol lipase in the regulation of endocannabinoid signaling

Yuki Hashimotodani, Takako Ohno-Shosaku, Masanobu Kano

NEUROSCIENCE RESEARCH, 58 S51-S51, 2007
Activation of NMDA receptors triggers retrograde endocannabinoid signal in hippocampal neurons

Takako Ohno-Shosaku, Masato Ano, Yuki Hashimotodani, Tadasato Nagano, Masanobu Kano

NEUROSCIENCE RESEARCH, 55 S208-S208, 2006
脳内マリファナ類似物質発生のメカニズム

橋本谷祐輝, 少作隆子, 狩野方伸

生化学, 78(2) 126-130, 2006 Peer-reviewedInvited
アセチルコリンと脳内マリファナ類似物質

狩野方伸, 少作隆子

豊田研究報告, (58) 85-91, May, 2005 Peer-reviewedInvited
Control of synaptic transmission in the CNS through endocannabinoid-mediated retrograde signaling

Ohno-Shosaku T, Maejima T, Yoshida T, Hashimoto K, Fukudome Y, Kano M

Dendritic Neurotransmitter Release, 269-281, 2005 Peer-reviewedInvited
マリファナ類似物質の逆行性伝達物質としての役割 (特集記憶・学習の分子基盤に迫る)

少作隆子, 狩野方伸

Molecular Medicine, 201 1087-1094, Sep, 2004 Peer-reviewedInvited
Endocannabinoid-Mediated Modulation of Excitatory and Inhibitory Synaptic Transmission.

Kano, M, Ohno-Shosaku, T, Maejima, T, Yoshida, T

"Excitatory-Inhibitory Balance: Synapses, Circuits, and Systems" edited by Hensch, T.K. and Fagiolini, M., 99-109, 2004 Peer-reviewedInvited
I. Basic Neuroscience 3. カンナビノイド受容体

少作隆子, 前島隆司, 狩野方伸

Annual Review 神経, 2003 18-24, Jan 25, 2003
Suppression of inhibitory transmitter release in the hippocampus mediated directly by presynaptic and indirectly by postsynaptic metabotropic receptors.

T Ohno-Shosaku, M Kano

JOURNAL OF PHARMACOLOGICAL SCIENCES, 91 20P-20P, 2003
神経・骨格筋系グルタミン酸受容体チャネルとシナプス可塑性 (〔2002年〕6月第5土曜特集イオンチャネルの最前線) -- (臓器でのイオンチャネルの働きと疾患)

少作隆子, 狩野方伸

医学のあゆみ, 201(13) 1123-1127, Jun, 2002 Peer-reviewedInvited
カンナビノイド受容体と逆行性シグナル伝達

前島隆司, 少作隆子, 狩野方伸

Clin Neurosci, 19(12) 1431, Dec 1, 2001
Endocannabinoid-mediated retrograde modulation of synaptic transmission

NEUROSCIENCE RESEARCH, Supplement 25 S179, Sep, 2001
内因性カンナビノイドによる逆行性シナプス伝達調節

少作隆子, 前島隆司, 水島伊知郎, 米田憲秀, 狩野方伸

神経化学, 40(2-3) 440-440, Sep, 2001

Presentations

3 レバー・オペラント課題における学習効率と行動柔軟性：カンナビノイド系とテオブロミン

米田貢, 谷上颯, 中川雅崇, 臼田明莉, 杉本直俊, 少作隆子

第12回日本作業療法研究学会学術大会, Oct 13, 2018
The performance of aged mice in 1-lever, 3-lever, and reverse 3-lever operant task

•Nakagawa M, Usuda A, Tanigami H, Yoneda M, Sugimoto N, Ohno-Shosaku T

Jul 27, 2018
The relationship between prediction-based feedforward motor control during loading task and motor learning during lever pressing task

•Ota T, Kikuchi Y, Yoneda M, Koike Y, Ohno-Shosaku T

Jul 26, 2018
運動学習および行動柔軟性に影響をおよぼす因子：カンナビノイド系とテオブロミン

米田貢, 谷上颯, 臼田明莉, 中川雅崇, 菊池ゆひ, 杉本直俊, 少作隆子

第95回日本生理学会大会, Mar 30, 2018
3レバーオペラント課題における2-AG合成酵素DGLα欠損マウスの適応行動の障害

米田貢, 谷上颯, 田端佑樹, 越後亮介, 少作隆子

39回日本生物学的精神医学会・第47回日本神経精神薬理学会合同年会, Sep 27, 2017
Positive effects of theobromine-containing diet on cerebral CREB/BDNF pathways and motor learning in mice

•Tanigami H, Yoneda M, Sugimoto N, Tabata Y, Katakura M, Matsuzaki K, Yachie A, Shido O, Ohno-Shosaku T

Jul 22, 2017
Impaired reinforcement learning and response inhibition in conflict decisions during probabilistic selection task in schizophrenia patients

•Kikuchi Y, Yoneda M, Terashima S, Takabayashi R, Ota T, Ohno-Shosaku T

Jul 22, 2017
2-AG合成酵素DGLα欠損マウスはCB1受容体欠損マウスと同様のレバー押し学習障害を示す

第94回日本生理学会大会, Mar 29, 2017
Theobromine crosses the blood brain barrier resulting in increased phosphorylation of vasodilator-stimulated phosphoprotein and cAMP-response element-binding protein in the mouse brain

Sugimoto N, Katakura M, Matsuzaki K, Yoneda M, Sumiyoshi E, Ohno-Shosaku T, Yachie A, Shido O

21st International Conference of FFC, Mar 25, 2017
Theobromine crosses the blood brain barrier in vivo resulting in increased phosphorylation of vasodilatorstimulated phosphoprotein in the mouse brain

Sugimoto N, Katakura M, Matsuzaki K, Ohno-Shosaku T, Yachie A, Shido O

Physiology 2016, Jul 30, 2016
3レバーオペラント課題を用いたマウスの運動学習および適応行動に対するテオブロミン摂取の効果

第39回日本神経科学大会, Jul 20, 2016
Theobromine, the primary methylxanthine found in Theobroma cacao, can pass through the blood-brain barrier in mice

Experimental Biology 2016, Apr 6, 2016
Examination of the effects of theobromine feeding on motor learning and adaptive behavior of mice by using three-lever operant task

Tanigami H, Yoneda M, Tabata Y, Sugimoto N, Ohno-Shosaku T

Mar 22, 2016
Impairment of adaptive behavior in CB1-knockout mice during the one-lever, three-lever and reverse three-lever tasks

Yoneda M, Tabata Y, Kikuchi Y, Ohno-Shosaku T

Neuroscience 2015, Jul 28, 2015
A CB1-independent enhancement of spontaneous synaptic activity by endogenously-released 2-arachidonoylglycerol in cultured hippocampal neurons

Ohno-Shosaku T, Kobayashi S, Nakamoto N, Takagi Y, Sugawara Y

Neuroscience 2015, Jul 28, 2015
A study on the role of CB1 receptors in motor learning using the three-lever operant task

Yoneda M, Tabata Y, Takabayashi R, Ohno-Shosaku T

Neuroscience 2014, Sep 12, 2014
Modulation of synaptic transmission by 2-arachidonoylglycerol and its metabolites

Ohno-Shosaku T, Kano M

Neuroscience 2014, Sep 12, 2014
Impairment of feed-forward motor control in patients with schizophrenia

Kikichi Y, Yoneda M, Echigo R, Nakagawa S, Koike Y, Ohno-Shosaku T

Neuroscience 2014, Sep 11, 2014
Differences in the muscarinic effects of the antipsychotic clozapine and its metabolite N-desmethylclozapine between excitatory and inhibitory hippocampal neurons

Sugawara Y, Ota T, Ohno-Shosaku T

Neuroscience 2014, Sep 11, 2014
Individual differences in prediction-based motor control assessed in unloading task by measuring hand movements and electromyogram

Kikuchi, Y, Hama N, Wakabayashi Y, Kumakiri Y, Yoneda M, Koike Y, Ohno-Shosaku T

Neuro2013, Jun 2, 2013

Professional Memberships

Research Projects

Basic research for rehabilitation: a focus on roles of basal ganglia and cerebellum in behavioral flexibility

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2023
Examination of the thalamic reticular nucleus dysfunction hypothesis of schizophrenia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2019 - Mar, 2022

Ohno-Shosaku Takako
嗜好食品による抗老化と認知機能促進の分子基盤及び機能的形態学的機序の解明

基盤研究（Ｂ）, 文部科学省, 2017 - 2020

杉本直俊
リハビリテーション技術確立のための運動学習における行動柔軟性に関する基礎研究

基盤研究（Ｃ）, 文部科学省, 2016 - 2018

米田貢
シナプスにおける逆行性シグナルが生後発達期の機能的神経回路形成に果たす役割の解明

特別推進研究, 文部科学省, 2013 - 2017

狩野方伸
カンナビノイドと他の脂質メディエーターとのクロストーク

基盤研究（Ｃ）, 文部科学省, 2014 - 2016

少作隆子
嗜好食品ががん化、老化、発達障害を予防する―メチルキサンチン誘導体を中心として―

基盤研究（Ｂ）, 文部科学省, 2013 - 2016

杉本直俊
脳内カンナビノイド系が変化するメカニズムの解明

基盤研究（Ｃ）, 文部科学省, 2011 - 2013

少作隆子
内因性カンナビノイドによる逆行性シナプス伝達の脳機能・脳病隊における役割の解明

基盤研究（Ｓ）, 文部科学省, 2009 - 2012

狩野方伸
カンナビノイド依存性シナプス可塑性のメカニズム

基盤研究（Ｃ）, 文部科学省, 2008 - 2010

少作隆子
ムスカリン性アセチルコリン受容体を介するシグナルの多様性および相互依存性の解析

特定領域研究, 文部科学省, 2008 - 2009

少作隆子
内因性カンナビノイドを介する逆行性シナプス伝達のメカニズムとその生理的意義の解明

基盤研究（Ｓ）, 文部科学省, 2005 - 2008

狩野方伸
シグナルの同期性を検出する分子メカニズム

特定領域研究, 文部科学省, 2006 - 2007

少作隆子
PLC活性のリアルタイム測定法を用いた細胞内シグナルのクロストークの解析

萌芽研究, 文部科学省, 2005 - 2007

少作隆子
シナプス伝達調節におけるホスホリパーゼCβの同期性検出器としての役割

特定領域研究, 文部科学省, 2005 - 2005

少作隆子
逆行性シグナルとして働く内因性カンナビノイドの同定およびその放出メカニズムの解明

基盤研究（Ｂ）, 文部科学省, 2003 - 2005

少作隆子
シナプス可塑性の誘導における内因性カンナビノイドの役割

特定領域研究, 文部科学省, 2003 - 2004

少作隆子
Mode of action and physiological significance of endogenous cannabinoids as a retrograde messenger at central synapses

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, 2001 - 2004

KANO Masanobu, SHOSAKU Takako, TABATA Toshihide
抑制性シナプス伝達の可塑性の生理的意義

基盤研究（Ｃ）, 文部科学省, 2001 - 2002

少作隆子
シナプス伝達調節における逆行性シグナルおよびグリアの関与

基盤研究（Ｃ）, 文部科学省, 1999 - 2000

少作隆子

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