MISC

2006年7月

Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
  • Kan Yoshida
  • ,
  • Shigeyuki Takatsuka
  • ,
  • Eriko Hatada
  • ,
  • Hiroyuki Nakamura
  • ,
  • Akira Tanaka
  • ,
  • Koichiro Ueki
  • ,
  • Kiyomasa Nakagawa
  • ,
  • Yasunori Okada
  • ,
  • Etsuhide Yamamoto
  • ,
  • Ryuuzi Fukuda

102
1
開始ページ
22
終了ページ
27
記述言語
英語
掲載種別
DOI
10.1016/j.tripleo.2005.07.013
出版者・発行元
MOSBY, INC

Objective. To investigate whether matrix metalloproteinases (MMPs) and/or aggrecanase in synovial fluid can be used as biochemical markers in the diagnosis of internal derangement (ID) of the temporomandibular joint (TMJ).
Study design. Forty-four samples of synovial fluid were obtained from 35 patients with ID and osteoarthritis (OA) and 15 normal samples from 10 asymptomatic volunteers. MMP-2, -9, and aggrecanase in the synovial fluid were examined by immunoblotting.
Results. The incidences of MMP-2, -9, and aggrecanase expression in the ID and OA group were significantly higher than those in the normal group (P <.05). Those with anterior disc displacement without reduction and severe OA showed significantly high expression of MMP-9 compared with other disease subgroups (P <.05). Conversely, comparatively high expression of MMP-2 and aggrecanase was shown in the early-stage OA group. However, there was no significant difference in expression of MMP-2 and aggrecanase among disease subgroups.
Conclusions. These findings suggested that expression of aggrecanase could be a potential biochemical marker for articular cartilage degradation in ID of the TMJ.

Web of Science ® 被引用回数 : 36

リンク情報
DOI
https://doi.org/10.1016/j.tripleo.2005.07.013
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000239158800005&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.tripleo.2005.07.013
  • ISSN : 1079-2104
  • Web of Science ID : WOS:000239158800005

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