論文

2021年8月4日

Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population

PLOS ONE
  • Youhei Yamada
  • Haruki Nakamura
  • Hiromasa Tsujiguchi
  • Akinori Hara
  • Sakae Miyagi
  • Takayuki Kannon
  • Takehiro Sato
  • Kazuyoshi Hosomichi
  • Thao Thi Thu Nguyen
  • Yasuhiro Kambayashi
  • Yukari Shimizu
  • Kim Oanh Pham
  • Keita Suzuki
  • Fumihiko Suzuki
  • Tomoko Kasahara
  • Hirohito Tsuboi
  • Atsushi Tajima
  • Hiroyuki Nakamura
  • 全て表示

16
8
開始ページ
e0255444
終了ページ
e0255444
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0255444
出版者・発行元
Public Library of Science (PLoS)

A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0255444
URL
https://dx.plos.org/10.1371/journal.pone.0255444
ID情報
  • DOI : 10.1371/journal.pone.0255444
  • eISSN : 1932-6203

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