2021年8月4日
Relationships among the β3-adrenargic receptor gene Trp64Arg polymorphism, hypertension, and insulin resistance in a Japanese population
PLOS ONE
- 巻
- 16
- 号
- 8
- 開始ページ
- e0255444
- 終了ページ
- e0255444
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1371/journal.pone.0255444
- 出版者・発行元
- Public Library of Science (PLoS)
A polymorphism in the ADRB3 gene (Trp64Arg) has been associated with obesity, insulin resistance, and hypertension. This cross-sectional study investigated the relationships among this polymorphism, hypertension, and insulin resistance values (HOMA-IR) in 719 Japanese subjects aged 40 years and older. The genotype frequencies of Trp64Trp (homozygous, wild), Trp64Arg (heterozygous, variant), and Arg64Arg (homozygous, variant) were 466 (65%), 233 (32%), and 20 (3%), respectively. Insulin resistance was associated with an increased risk of hypertension in a Japanese population. This relationship was dependent on the presence or absence of the Trp64Arg polymorphism (odds ratio, 2.054; confidence interval, 1.191 to 3.541; P value, 0.010). Therefore, the Trp64Arg polymorphism of ADRB3 was associated with hypertension and insulin resistance in a healthy Japanese population. This relationship, which was dependent on the polymorphism, may predict the development of hypertension and diabetes.
- リンク情報
- ID情報
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- DOI : 10.1371/journal.pone.0255444
- eISSN : 1932-6203