Haruhiro Higashida

Profile Information

Affiliation: Kanazawa University

Degree: 医学博士

Researcher number: 30093066
J-GLOBAL ID: 200901079322545375
researchmap Member ID: 1000019819

External link: http://web.kanazawa-u.ac.jp/~med63/index.html

Research Interests

Research Areas

Education

- 1975

Nagoya University
- 1975

Graduate School, Division of Medicine, Nagoya University
- 1971

Medical Course, School of Medicine, Gifu University
- 1971

Faculty of Medicine, Gifu University

Committee Memberships

Awards

Papers

346

Two oxytocin analogs, N-(p-fluorobenzyl) glycine and N-(3-hydroxypropyl) glycine, induce uterine contractions ex vivo in ways that differ from that of oxytocin

Stanislav M. Cherepanov, David Desseauve, Teruko Yuhi, Takashi Iizuka, Takashi Hosono, Masanori Ono, Hiroshi Fujiwara, Shigeru Yokoyama, Satoshi Shuto, Haruhiro Higashida

PLOS ONE, 18(2) e0281363, Feb 9, 2023 Peer-reviewed
Infant Stimulation Induced a Rapid Increase in Maternal Salivary Oxytocin.

Kana Minami, Teruko Yuhi, Haruhiro Higashida, Shigeru Yokoyama, Takahiro Tsuji, Chiharu Tsuji

Brain sciences, 12(9), Sep 15, 2022
Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism.

Chiharu Tsuji, Kazumi Furuhara, Ryuko Mizutani, Kana Minami, Pinyue Fu, Jing Zhong, Haruhiro Higashida, Shigeru Yokoyama, Takahiro Tsuji

Neuroscience letters, 788 136827-136827, Aug 6, 2022
Receptor for advanced glycation end-products and child neglect in mice: A possible link to postpartum depression

Haruhiro Higashida, Maria Gerasimenko, Yasuhiko Yamamoto

Comprehensive Psychoneuroendocrinology, 11 100146-100146, Aug, 2022
Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Haruhiro Higashida, Kazumi Furuhara, Olga Lopatina, Maria Gerasimenko, Osamu Hori, Tsuyoshi Hattori, Yasuhiko Hayashi, Stanislav M. Cherepanov, Anna A. Shabalova, Alla B. Salmina, Kana Minami, Teruko Yuhi, Chiharu Tsuji, PinYue Fu, Zhongyu Liu, Shuxin Luo, Anpei Zhang, Shigeru Yokoyama, Satoshi Shuto, Mizuki Watanabe, Koichi Fujiwara, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto

Frontiers in Neuroscience, 16, Jul 7, 2022
Dual Nature of RAGE in Host Reaction and Nurturing the Mother-Infant Bond.

Yu Oshima, Ai Harashima, Seiichi Munesue, Kumi Kimura, Nontaphat Leerach, Hisanori Goto, Mariko Tanaka, Akane Niimura, Kenjiro Hayashi, Hiroshi Yamamoto, Haruhiro Higashida, Yasuhiko Yamamoto

International journal of molecular sciences, 23(4), Feb 14, 2022
Oral Supplementation with L-Carnosine Attenuates Social Recognition Deficits in CD157KO Mice via Oxytocin Release.

Takahiro Tsuji, Kazumi Furuhara, Maria Gerasimenko, Anna Shabalova, Stanislav M Cherepanov, Kana Minami, Haruhiro Higashida, Chiharu Tsuji

Nutrients, 14(4), Feb 14, 2022
Use of Cocultures to Measure the Blood-Brain Barrier Permeability of Oxytocin.

Yasuhiko Yamamoto, Ai Harashima, Sei-Ichi Munesue, Haruhiro Higashida

Methods in molecular biology (Clifton, N.J.), 2384 247-255, 2022
An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice.

Stanislav M Cherepanov, Maria Gerasimenko, Teruko Yuhi, Anna Shabalova, Hong Zhu, Shigeru Yokoyama, Alla B Salmina, Shei-Ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Haruhiro Higashida

Peptides, 146 170649-170649, Dec, 2021
Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum.

Maria Gerasimenko, Olga Lopatina, Seiichi Munesue, Ai Harashima, Shigeru Yokoyama, Yasuhiko Yamamoto, Haruhiro Higashida

Physiology & behavior, 235 113395-113395, Jun 1, 2021
Experimental Attempt on Walking Behavior and Stress Assessment in a Completely Darkened Tunnel

Miho Seike, Nobuyoshi Kawabata, Masato Hasegawa, Chiharu Tsuji, Haruhiro Higashida, Teruko Yuhi

Infrastructures, 6(5) 75-75, May 13, 2021
Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.

Stanislav M Cherepanov, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Shigeru Yokoyama, Keiichi I Nakayama, Masaaki Nishiyama, Haruhiro Higashida

BMC neuroscience, 22(1) 32-32, May 1, 2021
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD.

Jureepon Roboon, Tsuyoshi Hattori, Hiroshi Ishii, Mika Takarada-Iemata, Dinh Thi Nguyen, Collin D Heer, Denis O'Meally, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida, Osamu Hori

Journal of neurochemistry, 158(2) 311-327, Apr 19, 2021
Transport of oxytocin to the brain after peripheral administration by membrane-bound or soluble forms of receptors for advanced glycation end-products.

Sei-Ichi Munesue, MingKun Liang, Ai Harashima, Jing Zhong, Kazumi Furuhara, Elizabeta B Boitsova, Stanislav M Cherepanov, Maria Gerasimenko, Teruko Yuhi, Yasuhiko Yamamoto, Haruhiro Higashida

Journal of neuroendocrinology, 33(3) e12963, Mar, 2021
A huggable device can reduce the stress of calling an unfamiliar person on the phone for individuals with ASD.

Hidenobu Sumioka, Hirokazu Kumazaki, Taro Muramatsu, Yuichiro Yoshikawa, Hiroshi Ishiguro, Haruhiro Higashida, Teruko Yuhi, Masaru Mimura

PloS one, 16(7) e0254675, 2021
Oxytocin-Trust Link in Oxytocin-Sensitive Participants and Those Without Autistic Traits.

Hirofumi Kurokawa, Yusuke Kinari, Hiroko Okudaira, Kiyotaka Tsubouchi, Yoshimichi Sai, Mitsuru Kikuchi, Haruhiro Higashida, Fumio Ohtake

Frontiers in neuroscience, 15 659737-659737, 2021
Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior.

Nontaphat Leerach, Ai Harashima, Seiichi Munesue, Kumi Kimura, Yu Oshima, Hisanori Goto, Hiroshi Yamamoto, Haruhiro Higashida, Yasuhiko Yamamoto

Glycoconjugate journal, 38(3) 303-310, Oct 27, 2020
Deletion of CD38 and supplementation of NAD+ attenuate axon degeneration in a mouse facial nerve axotomy model.

Yuji Takaso, Masao Noda, Tsuyoshi Hattori, Jureepon Roboon, Miyako Hatano, Hisashi Sugimoto, Charles Brenner, Yasuhiko Yamamoto, Hiroshi Okamoto, Haruhiro Higashida, Makoto Ito, Tomokazu Yoshizaki, Osamu Hori

Scientific reports, 10(1) 17795-17795, Oct 20, 2020
Participatory Art Activities Increase Salivary Oxytocin Secretion of ASD Children.

Sanae Tanaka, Aiko Komagome, Aya Iguchi-Sherry, Akiko Nagasaka, Teruko Yuhi, Haruhiro Higashida, Maki Rooksby, Mitsuru Kikuchi, Oko Arai, Kana Minami, Takahiro Tsuji, Chiharu Tsuji

Brain sciences, 10(10), Sep 27, 2020 Peer-reviewed
Characterization of Chick Gizzard Extract That Promotes Neurite Outgrowth in Cultured Ciliary Neurons

Naomasa Miki, Yokichi Hayashi, Haruhiro Higashida

Journal of Neurochemistry, 37(3) 627-633, Sep, 2020 Peer-reviewed

Misc.

185

注目の遺伝子(第47回)パターン認識受容体RAGEはオキシトシンと結合し脳内への輸送を行う

東田陽博, 山本靖彦

分子精神医学, 19(4) 259-261, Oct, 2019
Experimental Investigation Regarding Evacuation Speed and Stress Assessment by Oxytocin Concentration Measurement in Full-Scale Tunnel

SEIKE Miho, TSUJI Chiharu, KAWABATA Nobuyoshi, Hasegawa Masato, HIGASHIDA Haruhiro, YUHI Mitsuko

The Proceedings of Mechanical Engineering Congress, Japan, 2018 S0540301, 2018
自閉スペクトラム症(ASD)

東田陽博

ファルマシア, 53(8) 801_1-801_1, 2017
たどり着けた記憶研究:ニーレンバーグ先生との40年

東田陽博

ファルマシア, 53(8) 768-770, 2017
Oxytocin and social behavior : Autism spectrum disorder revisited from oxytocin secretion mechanism

東田陽博, 横山茂, 由比光子, 辻知陽, 廣澤徹, 菊知充, 橋本隆紀, 三邉義雄

精神科 = Psychiatry, 30(1) 75-80, Jan, 2017
オキシトシンレセプター遺伝子の発現制御機構の解明

堀家慎一, 目黒牧子, 沼田紗弥, 沼田紗弥, 本田俊哉, 本田俊哉, 岡田源作, 横山茂, 東田陽博

日本遺伝学会大会プログラム・予稿集, 88th 129, Aug 22, 2016
オキシトシン受容体遺伝子の発現制御機構の解明

堀家慎一, 目黒牧子, 沼田紗弥, 沼田紗弥, 本田俊哉, 本田俊哉, 岡田源作, 横山茂, 東田陽博

日本分子生物学会年会プログラム・要旨集(Web), 39th ROMBUNNO.2P‐0162 (WEB ONLY), 2016
脂質代謝特性に基づく自閉症予防法開発の試み (第55回日本児童青年精神医学会総会特集(2)児童青年精神医学の再構成と挑戦 : 支援から予防へ) -- (シンポジウム予防精神医学の可能性を探る)

松﨑秀夫, 東田陽博, 森則夫

児童青年精神医学とその近接領域, 56(4) 616-620, 2015
せるてく・あらかると CD38とオキシトシンによる自閉症研究 (特集自閉症の生物学)

東田陽博

細胞工学, 34(5) 487-489, 2015
The 3rd Summit for Child Mental Development of Kanazawa University

123(4) 126-126, Dec 1, 2014
自閉症スペクトラム障害とオキシトシン (特集自閉症の分子基盤)

東田陽博, 横山茂, 棟居俊夫

分子精神医学, 14(2) 74-80, Apr, 2014
Generation of Mice Harbouring Human-type Oxytocin Receptor Gene

西森克彦, 東田陽博, 横山茂

研究助成論文集, (50) 37-43, 2014
3-7歳の自閉症スペクトラム児における聴覚誘発脳磁場の側性化と言語発達

吉村優子, 菊知充, 上野沙奈絵, 平石博敏, 長谷川千秋, レメイン・ジェラード, 下道喜代美, 棟居俊夫, 坪川恒久, 東田陽博, 三邉義雄

臨床神経生理学, 41(5) 493-493, Oct, 2013
脳オキシトシン分泌制御,CD38の一塩基多型と自閉症の社会性障害の関連 (第14回感情・行動・認知(ABC)研究会)

東田陽博

分子精神医学, 13(2) 160-162, Apr, 2013
The roles of oxytocin and CD38 in social or parental behaviors

Olga Lopatina, Alena Inzhutova, Alla B. Salmina, Haruhiro Higashida

FRONTIERS IN NEUROSCIENCE, 6, 2013
Social memory and autism: recovery of autistic disturbance by intranasal or subcutaneous OT administration and single nucleotide polymorphisms of CD38.

Higashida Haruhiro

Drug Delivery System, 28(4) 310-317, 2013
自閉症発症機序におけるエピゲノムの重要性~オキシトシンレセプタープロモーター領域のDNAメチル化解析~

堀家慎一, 岡田源作, 棟居俊夫, 東田陽博, 横山茂, 目黒牧子

日本人類遺伝学会大会プログラム・抄録集, 58th 163, 2013
Functional Characterization of Cardiac Ion Channel Gene Variants in Lone Atrial Fibrillation

Kenshi Hayashi, Satoyuki Tani, Li Liu, Hidekazu Ino, Noboru Fujino, Tetsuo Konno, Akihiko Hodatsu, Toyonobu Tsuda, Akihiro Inazu, Haruhiro Higashida, Masa-aki Kawashiri, Masakazu Yamagishi

CIRCULATION, 126(21), Nov, 2012
Roles of oxytocinase on social behavior in males and the retrieval behavior of females in mice

M. Liang, J. Zhong, C. Higashida, H. Higashida

JOURNAL OF NEUROCHEMISTRY, 123 128-128, Oct, 2012
An immunohistological study of expression of BST1/CD157 in embryonic and developed mice

J. Zhong, O. Lopatina, C. Higashida, H. Higashida

JOURNAL OF NEUROCHEMISTRY, 123 102-102, Oct, 2012

Books and Other Publications

イオンチャネル (2) (最新医学からのアプローチ (7))

東田陽博

メジカルビュー社, Jan, 1993 (ISBN: 489553328X)
イオンチャネル (1) (最新医学からのアプローチ (6))

東田陽博

メジカルビュー社, Jan, 1993 (ISBN: 4895533271)

Professional Memberships

Works

Research Projects

父親になる男性の養育ホルモン（オキシトシン）の変動およびその役割の解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

南香奈, 辻知陽, 東田陽博, 鏡真美
Cognitive Deficits and Oxytocin Signaling in Cortical Parvalbumin Neurons in Schizophrenia

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

HASHIMOTO TAKANORI, LEWIS David
Analysis of development of oligodendtocytes in autism-related mouse model

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Hattori Tsuyoshi, HORI Osamu, TAKARADA Mika, ISHII Hiroshi, Higashida Haruhiro
Medicinal chemical study by the three-dimensional structural diversity-oriented strategy based on the characteristic steric and stereoelectronic features of cyclopropane

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SHUTO Satoshi, FUKUDA Hayato, MINAMI Masabumi, HIGASHIDA Haruhiro, HIROKAWA Takatugu
Study of novel physiological function by the system with oxytocin and its receptor.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

NISHIMORI Katsuhiko, HIGASHIDA Haruhiho, ONAKA Tatushi, SAKAMOTO Hirotaka, KURODA Kumi, YAO Hiromu
Functional screening and study of genes based on aggressive behavior, which is involved in autism and human developmental disorders.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

KOIZUMI Keita, MUNESUE Toshio, HIGASHIDA Haruhiro, NAKAJIMA Hideo
Gene analysis for the inherited arrhythmia and functional characterization of disease-causing rare variants by using zebrafish

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

GAMOU TADATSUGU, HAYASHI Kenshi, KONNO Tetsuo, HIGASHIDA Haruhiro
Activation mechanism of cyclic ADP-ribose-synthesizing enzyme CD38

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

MINAKO Hashii, HIGUCHI Yoshihiro, HIGASHIDA Haruhiro, MATSUKAWA Shigeru
Gene analysis for the inherited bradyarrhythmia and characterization of cardiosphere-derived cells to create biological pacemakers

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

HAYASHI Kenshi, FUJINO Noboru, KURATA Yasutaka, YAMAGISHI Masakazu, HIGASHIDA Haruhiro, SAKAMOTO Yuichiro
Identification of novel nerve injury-induced proteins and their roles in ion channel modulation and pain transduction

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

YOKOYAMA Shigeru, YOSHIKAWA Hiroaki, HIGASHIDA Haruhiro
Two steps screening of autistic genes by using Fly/mouse as model animals.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

KOIZUMI Keita, HIGASHIDA Haruhiro, MUNESUE Toshio
Neurochemical studies on molecules involved in social recognition and research on genes and therapy in autism.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2007 - 2009

HIGASHIDA Haruhiro, YOKOYAMA Shigeru, HASHII Minako, KOIZUMI Keita, MUNESUE Toshio, KIKUCHI Mituru, MINABE Yoshio
細胞外サイクリックADPリボースのセンサー機構

科学研究費助成事業特定領域研究, 日本学術振興会, 2007 - 2008

橋井美奈子, 東田陽博, 横山茂
機能性バイオ融合ナノ粒子と超音波化学をカップリングした新規がん治療

科学研究費助成事業特定領域研究, 日本学術振興会, 2006 - 2007

清水宣明, 東田陽博, 荻野千秋
Ionic channel expression in primary afferent Aβ fibers:analysis of regulatory mechanism and therapeutic application to chronic pain

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2006 - 2007

YOKOYAMA Shigeru, HIGASHIDA Haruhiro, IKEDA Kazuo
機能性生体分子を配向した光触媒ナノ粒子の創製とその医療応用

科学研究費助成事業萌芽研究, 日本学術振興会, 2006 - 2007

清水宣明, 荻野千秋, 東田陽博
ラット新生仔脳及びCD38ノックアウトマウス脳のADPリボシルシクラーゼの精製

科学研究費助成事業萌芽研究, 日本学術振興会, 2004 - 2006

東田陽博, 横山茂, 橋井美奈子
組織認識能を有する二酸化チタン・ナノ粒子の新規がん治療への応用

科学研究費助成事業特定領域研究, 日本学術振興会, 2005 - 2005

清水宣明, 東田陽博, 荻野千秋
Aキナーゼアンカータンパク(AKAP)依存的シナプス後電位:終止の分子メカニズム

科学研究費助成事業特定領域研究, 日本学術振興会, 2005 - 2005

東田陽博, 横山茂
機能性バイオ融合ナノ粒子の創製とその医療への応用

科学研究費助成事業萌芽研究, 日本学術振興会, 2004 - 2005

清水宣明, 山田外史, 荻野千秋, 東田陽博, 佐伯義光

Industrial Property Rights

特開2018-150284 乳児の社会脳発達促進用栄養組成物

東田陽博, 山本靖彦, 原島愛, 出口喜三郎
特開2016-149988 自閉症スペクトラムの検査方法。

横山茂, 東田陽博, 棟居俊夫
特開2016-114573 オキシトシン検出のためのサンプルの前処理方法

東田陽博, 山本靖彦, 棟居聖一, 原島愛, 出口喜三郎
特開2016-113433 オキシトシントランスポーター

東田陽博, 山本靖彦, 山本博, 棟居聖一, 原島愛, 堀修, 出口喜三郎
WO2016-002926 新規オキシトシン誘導体およびそれを含む医薬組成物

東田陽博, 周東智, 水野彰
特開2015-021853 精神症状モデル動物を用いた医薬品のスクリーニング

東田陽博
特許第4905901号ＣＤ３８による自閉症の診断と治療

東田陽博
WO2008-059991 CD38による自閉症の診断と治療

東田陽博
WO2007-001010 パーキンソン病の治療のための医薬

東田陽博, 横山茂, 金鐸, 大熊勝治, 清水宣明, 平井宏和, 村松慎一
特許第3772188号神経変性疾患治療薬又は遺伝性脳疾患治療薬のスクリーニング方法

東田陽博, 星直人
神経変性疾患薬又は遺伝性脳疾患薬のスクリ-ニング方法

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