論文

査読有り 国際誌
2020年4月

Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice.

Hormones and behavior
  • Anna A Shabalova
  • ,
  • Mingkun Liang
  • ,
  • Jing Zhong
  • ,
  • Zhiqi Huang
  • ,
  • Chiharu Tsuji
  • ,
  • Natalia A Shnayder
  • ,
  • Olga Lopatina
  • ,
  • Alla B Salmina
  • ,
  • Hiroshi Okamoto
  • ,
  • Yasuhiko Yamamoto
  • ,
  • Zeng-Guo Zhong
  • ,
  • Shigeru Yokoyama
  • ,
  • Haruhiro Higashida

120
開始ページ
104695
終了ページ
104695
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.yhbeh.2020.104695

In mammals, the development of healthy offspring requires maternal care. Behavior by lactating mothers toward other individuals is an important component of maternal aggression. However, it is unclear whether fathers display aggression primed by pups (an external factor), and the protection mechanism is poorly understood. To address this question, we examined paternal aggression in the ICR mouse strain. We found that sires exposed to cues from pups and lactating dams showed stronger aggression toward intruders than did sires that were deprived of family cues or exposed to nonlactating mates. c-Fos immunohistochemistry showed that cells in both the paraventricular and supraoptic nuclei (PVN and SON, respectively) in the hypothalamus of sires exposed to any cues were highly activated. However, c-Fos activation in oxytocinergic neurons was increased only in sires exposed to pup cues and solely in the PVN. In Cd38-knockout sires, the presence of pups induced no or reduced parental aggression; however, this phenotype was recovered, that is, aggression increased to the wild-type level, after intraperitoneal administration of oxytocin (OT). Specific c-Fos activation patterns induced by pup cues were not found in the PVN of knockout sires. These results demonstrate that the PVN is one of the primary hypothalamic areas involved in paternal aggression and suggest that a CD38-dependent OT mechanism in oxytocinergic neurons is critical for part of the behavior associated with the protection of offspring by nurturing male mice.

リンク情報
DOI
https://doi.org/10.1016/j.yhbeh.2020.104695
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31987898
ID情報
  • DOI : 10.1016/j.yhbeh.2020.104695
  • PubMed ID : 31987898

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