論文

国際誌
2020年12月

Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging.

PloS one
  • Maria Gerasimenko
  • ,
  • Olga Lopatina
  • ,
  • Anna A Shabalova
  • ,
  • Stanislav M Cherepanov
  • ,
  • Alla B Salmina
  • ,
  • Shigeru Yokoyama
  • ,
  • Hisanori Goto
  • ,
  • Hiroshi Okamoto
  • ,
  • Yasuhiko Yamamoto
  • ,
  • Katsuhiko Ishihara
  • ,
  • Haruhiro Higashida

15
12
開始ページ
e0244022
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0244022

The ability of CD38 and CD157 to utilize nicotinamide adenine dinucleotide (NAD) has received much attention because the aging-induced elevation of CD38 expression plays a role in the senescence-related decline in NAD levels. Therefore, it is of interest to examine and compare the effects of age-associated changes on the general health and brain function impairment of Cd157 and Cd38 knockout (CD157 KO and CD38 KO) mice. The body weight and behaviors were measured in 8-week-old (young adult) or 12-month-old (middle-aged) male mice of both KO strains. The locomotor activity, anxiety-like behavior, and social behavior of the mice were measured in the open field and three-chamber tests. The middle-aged CD157 KO male mice gained more body weight than young adult KO mice, while little or no body weight gain was observed in the middle-aged CD38 KO mice. Middle-aged CD157 KO mice displayed increased anxiety-like behavior and decreased sociability and interaction compared with young adult KO mice. Middle-aged CD38 KO mice showed less anxiety and hyperactivity than CD157 KO mice, similar to young adult CD38 KO mice. The results reveal marked age-dependent changes in male CD157 KO mice but not in male CD38 KO mice. We discuss the distinct differences in aging effects from the perspective of inhibition of NAD metabolism in CD157 and CD38 KO mice, which may contribute to differential behavioral changes during aging.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0244022
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33326496
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7743928
ID情報
  • DOI : 10.1371/journal.pone.0244022
  • PubMed ID : 33326496
  • PubMed Central 記事ID : PMC7743928

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