Shigeru Yokoyama

Profile Information

Affiliation: Research Center for Child Mental Development, Kanazawa University

Degree: 博士(医学)(金沢大学)

Researcher number: 00210633
J-GLOBAL ID: 200901034589517954
researchmap Member ID: 1000019820

Research Interests

Research Areas

Education

Apr, 1985 - Mar, 1988

Immunobiology, Graduate School, Division of Medicine, Kanazawa University
Apr, 1979 - Mar, 1985

Kanazawa University

Committee Memberships

1999 - Present

-:日本神経化学会評議委員
1999

-: Japanese Society of Neurochemistry
1999

評議委員、シンポジウムプログラム委員, 日本神経化学会

Awards

2001

平成13年度本陣奨励金
1994

興和生命科学振興財団研究奨励金
1994

Grant-in aid from Kowa Life Science Foundation
1990

老人医療基金研究奨励金
1990

公益信託松原三郎記念精神医学育成基金
1990

Grant-in-aid from Foundation for Geriatric Medicine
1990

Grant-in-aid from Saburo Matsubara Memorial Psychiatry Foundation
1988

日本心臓財団研究助成金
1988

Grant-in-aid from Japan Heart Foundation

Papers

142

Two oxytocin analogs, N-(p-fluorobenzyl) glycine and N-(3-hydroxypropyl) glycine, induce uterine contractions ex vivo in ways that differ from that of oxytocin

Stanislav M. Cherepanov, David Desseauve, Teruko Yuhi, Takashi Iizuka, Takashi Hosono, Masanori Ono, Hiroshi Fujiwara, Shigeru Yokoyama, Satoshi Shuto, Haruhiro Higashida

PLOS ONE, 18(2) e0281363, Feb 9, 2023 Peer-reviewed
Infant Stimulation Induced a Rapid Increase in Maternal Salivary Oxytocin.

Kana Minami, Teruko Yuhi, Haruhiro Higashida, Shigeru Yokoyama, Takahiro Tsuji, Chiharu Tsuji

Brain sciences, 12(9), Sep 15, 2022
Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism.

Chiharu Tsuji, Kazumi Furuhara, Ryuko Mizutani, Kana Minami, Pinyue Fu, Jing Zhong, Haruhiro Higashida, Shigeru Yokoyama, Takahiro Tsuji

Neuroscience letters, 788 136827-136827, Aug 6, 2022
Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Haruhiro Higashida, Kazumi Furuhara, Olga Lopatina, Maria Gerasimenko, Osamu Hori, Tsuyoshi Hattori, Yasuhiko Hayashi, Stanislav M. Cherepanov, Anna A. Shabalova, Alla B. Salmina, Kana Minami, Teruko Yuhi, Chiharu Tsuji, PinYue Fu, Zhongyu Liu, Shuxin Luo, Anpei Zhang, Shigeru Yokoyama, Satoshi Shuto, Mizuki Watanabe, Koichi Fujiwara, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto

Frontiers in Neuroscience, 16, Jul 7, 2022
Effect of CNTNAP2 polymorphism on receptive language in children with autism Spectrum disorder without language developmental delay.

Yuka Shiota, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Sumie Iwasaki, Masuhiko Sano, Kyung-Min An, Shigeru Yokoyama, Mitsuru Kikuchi

Neuropsychopharmacology reports, Jun 22, 2022
Alterations in brain networks in children with sub-threshold autism spectrum disorder: A magnetoencephalography study.

Yuka Shiota, Daiki Soma, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Ken Yaoi, Sumie Iwasaki, Masafumi Kameya, Shigeru Yokoyama, Mitsuru Kikuchi

Frontiers in psychiatry, 13 959763-959763, 2022
An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice.

Stanislav M Cherepanov, Maria Gerasimenko, Teruko Yuhi, Anna Shabalova, Hong Zhu, Shigeru Yokoyama, Alla B Salmina, Shei-Ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Haruhiro Higashida

Peptides, 146 170649-170649, Dec, 2021
Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum.

Maria Gerasimenko, Olga Lopatina, Seiichi Munesue, Ai Harashima, Shigeru Yokoyama, Yasuhiko Yamamoto, Haruhiro Higashida

Physiology & behavior, 235 113395-113395, Jun 1, 2021
子どものこころの発達研究センターから展開するアジア発達障害共同研究拠点形成と共同利用推進

橘雅弥, 片山泰一, 谷池雅子, 横山茂, 土屋賢治, 平野好幸, 清水栄司, 松崎秀夫, 友田明美, 中村和彦, 佐藤真

脳と発達, 53(Suppl.) S327-S327, May, 2021
Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.

Stanislav M Cherepanov, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Shigeru Yokoyama, Keiichi I Nakayama, Masaaki Nishiyama, Haruhiro Higashida

BMC neuroscience, 22(1) 32-32, May 1, 2021
A common variant of CNTNAP2 is associated with sub-threshold autistic traits and intellectual disability.

Yuka Shiota, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Sumie Iwasaki, Kyung-Min An, Daiki Soma, Masuhiko Sano, Shigeru Yokoyama, Mitsuru Kikuchi

PloS one, 16(12) e0260548, 2021
Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging.

Maria Gerasimenko, Olga Lopatina, Anna A Shabalova, Stanislav M Cherepanov, Alla B Salmina, Shigeru Yokoyama, Hisanori Goto, Hiroshi Okamoto, Yasuhiko Yamamoto, Katsuhiko Ishihara, Haruhiro Higashida

PloS one, 15(12) e0244022, Dec, 2020
Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder.

Maria Gerasimenko, Stanislav M Cherepanov, Kazumi Furuhara, Olga Lopatina, Alla B Salmina, Anna A Shabalova, Chiharu Tsuji, Shigeru Yokoyama, Katsuhiko Ishihara, Charles Brenner, Haruhiro Higashida

Scientific reports, 10(1) 10035-10035, Jun 22, 2020 Peer-reviewed
Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice.

Anna A Shabalova, Mingkun Liang, Jing Zhong, Zhiqi Huang, Chiharu Tsuji, Natalia A Shnayder, Olga Lopatina, Alla B Salmina, Hiroshi Okamoto, Yasuhiko Yamamoto, Zeng-Guo Zhong, Shigeru Yokoyama, Haruhiro Higashida

Hormones and behavior, 120 104695-104695, Apr, 2020 Peer-reviewed
A monoclonal antibody raised against a synthetic oxytocin peptide stains mouse hypothalamic neurones.

Yuji Kogami, Takahiro Tsuji, Chiharu Tsuji, Shigeru Yokoyama, Kazumi Furuhara, Olga Lopatina, Anna Shabalova, Alla B Salmina, Yumi Watanabe, Tsuyoshi Hattori, Katsuhiko Nishimori, Kota Kodama, Haruhiro Higashida

Journal of neuroendocrinology, 32(4) e12815, Apr, 2020 Peer-reviewed
One Single Nucleotide Polymorphism of the TRPM2 Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population.

Naila Al Mahmuda, Shigeru Yokoyama, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Chiharu Tsuji, Haruhiro Higashida

Diseases (Basel, Switzerland), 8(1), Feb 7, 2020 Peer-reviewed
Characteristics of university students supported by counseling services: Analysis of psychological tests and pulse rate variability.

Yumi Adachi, Hiroaki Yoshikawa, Shigeru Yokoyama, Kazuo Iwasa

PloS one, 15(8) e0218357, 2020 Peer-reviewed
CD38, CD157, and RAGE as Molecular Determinants for Social Behavior.

Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M Cherepanov, Anna A Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-Ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B Salmina, Olga Lopatina

Cells, 9(1), Dec 25, 2019 Peer-reviewed
Synthesis of oxytocin derivatives lipidated via a carbonate or carbamate linkage as a long-acting therapeutic agent for social impairment-like behaviors.

Stanislav M Cherepanov, Risako Miura, Anna A Shabalova, Wataru Ichinose, Shigeru Yokoyama, Hayato Fukuda, Mizuki Watanabe, Haruhiro Higashida, Satoshi Shuto

Bioorganic & medicinal chemistry, 27(15) 3358-3363, Aug 1, 2019 Peer-reviewed
Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.

Wataru Ichinose, Stanislav M Cherepanov, Anna A Shabalova, Shigeru Yokoyama, Teruko Yuhi, Hiroaki Yamaguchi, Ayu Watanabe, Yasuhiko Yamamoto, Hiroshi Okamoto, Shinichi Horike, Junpei Terakawa, Takiko Daikoku, Mizuki Watanabe, Nariyasu Mano, Haruhiro Higashida, Satoshi Shuto

Journal of medicinal chemistry, 62(7) 3297-3310, Apr 11, 2019 Peer-reviewed

Major Misc.

膜電位依存性イオンチャネルの分子構造、多様性と神経機能調節

横山茂

金沢大学十全医学会雑誌, 115(3-4) 130-133, Dec, 2006
学会見聞記（第25回北米神経科学会）

横山茂

蛋白質核酸酵素, 41,391-393(4) 391-393, 1996

Books and Other Publications

子育てにかかわる遺伝子：オキシトシンバソプレシン・オキシトシンファミリー、ヒトゲノム事典（編＝井ノ上逸朗・今西規・河村正二・斎藤成也（編集委員長）・颯田葉子・田嶋敦）

横山茂 (Role: Contributor)

Nov 10, 2021 (ISBN: 9784910389127)
バソプレシン・オキシトシンファミリーバソプレシン・オキシトシンファミリー、ヒトゲノム事典（編＝井ノ上逸朗・今西規・河村正二・斎藤成也（編集委員長）・颯田葉子・田嶋敦）

横山茂 (Role: Contributor)

一色出版, Nov 10, 2021 (ISBN: 9784910389127)
自閉症という謎に迫る研究最前線報告（小学館新書）

金沢大学子どものこころの発達研究センター, 金沢大学子どものこころ, 発達研究センター

小学館, Dec 7, 2013
一次求心性Aβ繊維のイオンチャネル発現調節機構の解明と難治性疼痛治療への応用

横山, 茂

[横山茂], May, 2008
一次求心性Aβ線維のイオンチャネル発現異常が神経障害性疼痛発生に与える影響

横山, 茂ヨコヤマ, シゲル

[横山茂], May, 2007
電位依存性ナトリウム・カリウムチャネルの神経障害性疼痛に伴う発現異常の分子機構

[横山茂], May, 2003
シナプス伝達のダイナミクス―記憶と学習のメカニズムをさぐる (情報生物学シリーズ)

吉岡亨, 工藤佳久, 桐野豊

培風館, Dec, 1995 (ISBN: 4563038547)

Presentations

子どものこころの発達・脳から支援まで：オキシトシンによる社会性認識・行動調節

横山茂

日本認知・行動療法学会第47回大会, Oct 11, 2021 Invited
子どものこころの諸問題への科学的支援・アプローチについて

横山茂

愛知県議会人づくり・福祉対策特別委員会, Aug 26, 2021 Invited
Novel mechanisms of oxytocin release and oxytocin analogues in rodent and human social behaviors.

Yokoyama, S, Cherepanov, S. M, Higashida, H

12th World Congress on Neurophypophyseal Hormones (WNCH), Jul 26, 2017 Invited
自閉スペクトラム症の遺伝的側面

横山茂

聞イテミル・考エテミル！？：自閉スペクトラム症の現在と未来, Mar 17, 2017 Invited
CD157/BST-1 in neuropsychiatric disorders.

YOKOYAMA Shigeru

2016 Jeju CD38 and NAD meeting., Feb 17, 2016 Invited
Association study between the CD157/BST1 gene and autism spectrum disorders in a Japanese population.

Yokoyama, S, Mahmuda, N. A, Munesue, T, Higashida, H

WPA International Congress 2015, Nov 19, 2015 Invited
Neuroimaging and genetic association studies of the effects of oxytocin on socio-emotional regulation.

Yokoyama, S, Kikuchi, M, Munesue, T, Higashida, H

The 21st IACAPAP (The International Association for Child and Adorescent Psychiatry and Allied Professions) Congress 2014, Aug 13, 2014 Invited
発達障害と遺伝子

横山茂

第40回自閉症サイエンスカフェ「カフェで語ろう!!!自閉症」, May 22, 2014 Invited
Polymorphisms of CD38 and CD157 genes in autism spectrum disorders.

Yokoyama, S

2014 Jeju CD38 and NAD meeting, Feb 19, 2014 Invited
末梢神経切断・伸張動物実験モデルの遺伝子発現解析から神経再生医療を考える

横山茂

第４回神経再生医療研究会 in Sapporo, Feb 6, 2013 Invited
神経伝達物質受容体・イオンチャネルの疼痛発生への関与

横山茂

第23回がん診療拠点病院研修会「緩和ケア講習会」, Jun 7, 2010 Invited
Analysis of gene expression in injured peripheral nerve.

Yokoyama, S

The III rd Russia-Japan workshop on Neurosciences. ― Integrative Neurosciences: Molecular and Translational Medicine ―, Aug 21, 2008 Invited
Genetic analysis of peripheral nerve regeneration.

Yokoyama, S

Korea-Japan Symposium on Recent Advance in Medical Science, Nov 17, 2007 Invited
膜電位依存性カリウムチャネルによる神経機能調節の分子機構

横山茂

国立長寿医療センターNILSセミナー, Oct 3, 2003 Invited
受容体・イオンチャネル分子からみた疼痛発生のメカニズム

横山茂

第17回関東機能的脳外科カンファレンス, Sep 6, 2003 Invited
慢性疼痛の分子生物学的機序 —イオンチャネルの発現解析によるアプローチ—

横山茂

第3北海道機能神経外科研究会, Nov 16, 2002 Invited
8. バイオインフォマティクス -神経化学との接点を探る-

横山茂

第43回日本神経化学会大会シンポジウム, Oct 18, 2000 Invited
Na+チャンネル・K+チャンネルと知覚障害

横山茂

第42回日本神経化学会大会公開シンポジウム, Sep 16, 1999 Invited
遺伝子導入を用いたシナプス機能の解析

横山茂

第73回日本生理学会大会分科会, Apr 4, 1996 Invited
Kv1.2 およびKv3.1チャネルの構造と発現

横山茂, 川村哲朗, 星直人, 東田陽博

第18回日本神経科学会大会シンポジウム「K+チャネルの構造と機能」, Dec 8, 1994 Invited

Professional Memberships

Research Projects

Investigation of the symptom diversity corresponding to characteristics of brain activity in young children with autism spectrum disorder

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
シグマ受容体イメージングによるストレス性疾患の客観的早期診断法の開発

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2019 - Mar, 2022

柴和弘, 横山茂, 北村陽二, 小阪孝史
The biomarker corresponding to the symptom variety in children with autism spectrum disorder.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2020
自閉スペクトラム症幼児の症状多様性に対応する生物学的指標の検討

科研費基盤研究(B), 日本学術振興会科研費, Apr, 2017 - Mar, 2020

菊知充
自閉スペクトラム症治療薬としての長期作用型オキシトシン誘導体化合物の開発

橋渡し研究加速ネットワークプログラムシーズＡ, AMED, Apr, 2018 - Mar, 2019

横山茂
Generation of antigene-fixed nanifibers and its application to autoantibody detection

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Yokoyama Shigeru, YOSHIKAWA Hiroaki
Roles of autonomic nervous system and autoantibody in mental health Prospective study about effects of the aroma

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Hiroaki Yoshikawa
ナノファイバー技術を用いた自己抗体の簡便スクリーニングシステムの開発

橋渡し研究加速ネットワークプログラムシーズＡ, AMED, Apr, 2017 - Mar, 2018

横山茂
抗原固相化ナノファイバーの創製と新規自己抗体検出法開発への応用研究

:科研費挑戦的萌芽研究, 日本学術振興会, Apr, 2015 - Mar, 2018

横山茂
The genotype, the phenotype and the end-phenotype measured by MEG in autism spectrum disorder.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2017

Kikuchi Mitsuru
一方向配向コラーゲン含有ナノファイバーを基材とする神経再生チューブの開発

平成27年度第2回マッチングプランナープログラム「探索試験」, JST, Jan, 2016 - Jan, 2017

横山茂
A psychological and neuroimaging study regarding to self in children, adolescents and adults tih autism spectrum disorder

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

MUNESUE Toshio, YOKOYAMA Shigeru, MIURA Yui, KOSAKA Hirotaka, SAITOH Daisuke, MORITA Tomoyo, KOMEDA Hidetsugu
神経損傷誘導性糖蛋白Ｇｐｎｍｂがイオンチャネル活動調節・痛み情報伝達に果たす役割

科研費基盤研究(C), 日本学術振興会, Apr, 2012 - Mar, 2016

横山茂
神経内分泌仮説に基づく知能障害を有する自閉症スペクトラム障害の診断と治療の展開研究

脳科学戦略推進プログラム「精神・神経疾患の克服を目指す脳科学研究（課題F）」, 文部科学省, Apr, 2011 - Mar, 2016

東田陽博
The roles of glycoprotein non-metastatic melanoma B (Gpnmb) in the modulation of ion channel activities and pain conduction

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

SHIGERU Yokoyama, YOSHIKAWA Hiroaki
Autoimmune neurological diseases targeting neuronal acetylcholine receptor

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

Yoshikawa Hiroaki, YOKOYAMA Shigeru, ADACHI Yumi
非線維性VI型コラーゲンを含む生体吸収性ナノファイバーを用いた神経再生用ガイドチューブの開発

研究成果最適展開支援プログラム（A-STEP）探索タイプ, ＪＳＴ, Apr, 2012 - Mar, 2013

横山茂
損傷神経に誘導される新規蛋白がイオンチャネル活動調節・痛み情報伝達に果たす役割

科研費基盤研究(C), 日本学術振興会, Apr, 2009 - Mar, 2012

横山茂
重症筋無力症自己抗体のスペクトラムに関する研究

科研費基盤研究(C), 日本学術振興会, Apr, 2007 - Mar, 2011

吉川弘明
Identification of novel nerve injury-induced proteins and their roles in ion channel modulation and pain transduction

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2009 - 2011

YOKOYAMA Shigeru, YOSHIKAWA Hiroaki, HIGASHIDA Haruhiro

Industrial Property Rights

特開2014-171392 自閉症スペクトラムの検査方法及びオキシトシン投与による自閉症スペクトラムの治療効果を予測する方法。

横山茂, 棟居俊夫
特許第5370969号心筋障害の検査方法

吉川弘明, 横山茂, 丸田高広, 角弘諭, 根上昌子
特許第5271632号神経細胞死抑制作用をもつVI型コラーゲン

横山茂, 檜木茂, 池田和夫, 富田勝郎
特開2011-173793 アセチルコリン受容体クラスター形成阻害活性を有するアグリンを特異的に認識する抗体並びに該抗体を含むアセチルコリン受容体クラスター形成能促進剤及び該抗体を充填したアセチルコリン受容体クラスター形成能を阻害するアグリン除去カラム

吉川弘明, 横山茂, 丸田高広
特開2011-174707 心筋障害の検査方法

吉川弘明, 横山茂, 丸田高広, 角弘諭, 根上昌子
特開2011-173794 アセチルコリン受容体クラスター形成阻害剤

吉川弘明, 横山茂, 丸田高広
特開2010-037316 神経細胞死抑制作用をもつVI型コラーゲン

横山茂, 檜木茂, 池田和夫, 富田勝郎
WO2007-001010 パーキンソン病の治療のための医薬

東田陽博, 横山茂, 金鐸, 大熊勝治, 清水宣明, 平井宏和, 村松慎一

Profile Information

Research Interests

Research Areas

Education

Committee Memberships

Awards

Papers

Major Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

Industrial Property Rights

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