横山茂 (Shigeru Yokoyama) - マイポータル

基本情報

所属: 金沢大学子どものこころの発達研究センター教授 (センター長)

学位: 博士(医学)(金沢大学)

研究者番号: 00210633
J-GLOBAL ID: 200901034589517954
researchmap会員ID: 1000019820

研究キーワード

研究分野

学歴

1985年4月 - 1988年3月

金沢大学医学研究科病理系免疫生物学
1979年4月 - 1985年3月

金沢大学医学部医学科

委員歴

1999年 - 現在

-:日本神経化学会評議委員
1999年

-: Japanese Society of Neurochemistry
1999年

日本神経化学会評議委員、シンポジウムプログラム委員

受賞

2001年

平成13年度本陣奨励金
1994年

興和生命科学振興財団研究奨励金
1994年

Grant-in aid from Kowa Life Science Foundation
1990年

老人医療基金研究奨励金
1990年

公益信託松原三郎記念精神医学育成基金
1990年

Grant-in-aid from Foundation for Geriatric Medicine
1990年

Grant-in-aid from Saburo Matsubara Memorial Psychiatry Foundation
1988年

日本心臓財団研究助成金
1988年

Grant-in-aid from Japan Heart Foundation

論文

142

Two oxytocin analogs, N-(p-fluorobenzyl) glycine and N-(3-hydroxypropyl) glycine, induce uterine contractions ex vivo in ways that differ from that of oxytocin

Stanislav M. Cherepanov, David Desseauve, Teruko Yuhi, Takashi Iizuka, Takashi Hosono, Masanori Ono, Hiroshi Fujiwara, Shigeru Yokoyama, Satoshi Shuto, Haruhiro Higashida

PLOS ONE 18(2) e0281363 2023年2月9日査読有り
Infant Stimulation Induced a Rapid Increase in Maternal Salivary Oxytocin.

Kana Minami, Teruko Yuhi, Haruhiro Higashida, Shigeru Yokoyama, Takahiro Tsuji, Chiharu Tsuji

Brain sciences 12(9) 2022年9月15日
Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism.

Chiharu Tsuji, Kazumi Furuhara, Ryuko Mizutani, Kana Minami, Pinyue Fu, Jing Zhong, Haruhiro Higashida, Shigeru Yokoyama, Takahiro Tsuji

Neuroscience letters 788 136827-136827 2022年8月6日
Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside

Haruhiro Higashida, Kazumi Furuhara, Olga Lopatina, Maria Gerasimenko, Osamu Hori, Tsuyoshi Hattori, Yasuhiko Hayashi, Stanislav M. Cherepanov, Anna A. Shabalova, Alla B. Salmina, Kana Minami, Teruko Yuhi, Chiharu Tsuji, PinYue Fu, Zhongyu Liu, Shuxin Luo, Anpei Zhang, Shigeru Yokoyama, Satoshi Shuto, Mizuki Watanabe, Koichi Fujiwara, Sei-ichi Munesue, Ai Harashima, Yasuhiko Yamamoto

Frontiers in Neuroscience 16 2022年7月7日
Effect of CNTNAP2 polymorphism on receptive language in children with autism Spectrum disorder without language developmental delay.

Yuka Shiota, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Sumie Iwasaki, Masuhiko Sano, Kyung-Min An, Shigeru Yokoyama, Mitsuru Kikuchi

Neuropsychopharmacology reports 2022年6月22日
Alterations in brain networks in children with sub-threshold autism spectrum disorder: A magnetoencephalography study.

Yuka Shiota, Daiki Soma, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Ken Yaoi, Sumie Iwasaki, Masafumi Kameya, Shigeru Yokoyama, Mitsuru Kikuchi

Frontiers in psychiatry 13 959763-959763 2022年
An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice.

Stanislav M Cherepanov, Maria Gerasimenko, Teruko Yuhi, Anna Shabalova, Hong Zhu, Shigeru Yokoyama, Alla B Salmina, Shei-Ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Haruhiro Higashida

Peptides 146 170649-170649 2021年12月
Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum.

Maria Gerasimenko, Olga Lopatina, Seiichi Munesue, Ai Harashima, Shigeru Yokoyama, Yasuhiko Yamamoto, Haruhiro Higashida

Physiology & behavior 235 113395-113395 2021年6月1日
子どものこころの発達研究センターから展開するアジア発達障害共同研究拠点形成と共同利用推進

橘雅弥, 片山泰一, 谷池雅子, 横山茂, 土屋賢治, 平野好幸, 清水栄司, 松崎秀夫, 友田明美, 中村和彦, 佐藤真

脳と発達 53(Suppl.) S327-S327 2021年5月
Oxytocin ameliorates impaired social behavior in a Chd8 haploinsufficiency mouse model of autism.

Stanislav M Cherepanov, Maria Gerasimenko, Teruko Yuhi, Kazumi Furuhara, Chiharu Tsuji, Shigeru Yokoyama, Keiichi I Nakayama, Masaaki Nishiyama, Haruhiro Higashida

BMC neuroscience 22(1) 32-32 2021年5月1日
A common variant of CNTNAP2 is associated with sub-threshold autistic traits and intellectual disability.

Yuka Shiota, Tetsu Hirosawa, Yuko Yoshimura, Sanae Tanaka, Chiaki Hasegawa, Sumie Iwasaki, Kyung-Min An, Daiki Soma, Masuhiko Sano, Shigeru Yokoyama, Mitsuru Kikuchi

PloS one 16(12) e0260548 2021年
Distinct physical condition and social behavior phenotypes of CD157 and CD38 knockout mice during aging.

Maria Gerasimenko, Olga Lopatina, Anna A Shabalova, Stanislav M Cherepanov, Alla B Salmina, Shigeru Yokoyama, Hisanori Goto, Hiroshi Okamoto, Yasuhiko Yamamoto, Katsuhiko Ishihara, Haruhiro Higashida

PloS one 15(12) e0244022 2020年12月
Nicotinamide riboside supplementation corrects deficits in oxytocin, sociability and anxiety of CD157 mutants in a mouse model of autism spectrum disorder.

Maria Gerasimenko, Stanislav M Cherepanov, Kazumi Furuhara, Olga Lopatina, Alla B Salmina, Anna A Shabalova, Chiharu Tsuji, Shigeru Yokoyama, Katsuhiko Ishihara, Charles Brenner, Haruhiro Higashida

Scientific reports 10(1) 10035-10035 2020年6月22日査読有り
Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice.

Anna A Shabalova, Mingkun Liang, Jing Zhong, Zhiqi Huang, Chiharu Tsuji, Natalia A Shnayder, Olga Lopatina, Alla B Salmina, Hiroshi Okamoto, Yasuhiko Yamamoto, Zeng-Guo Zhong, Shigeru Yokoyama, Haruhiro Higashida

Hormones and behavior 120 104695-104695 2020年4月査読有り
A monoclonal antibody raised against a synthetic oxytocin peptide stains mouse hypothalamic neurones.

Yuji Kogami, Takahiro Tsuji, Chiharu Tsuji, Shigeru Yokoyama, Kazumi Furuhara, Olga Lopatina, Anna Shabalova, Alla B Salmina, Yumi Watanabe, Tsuyoshi Hattori, Katsuhiko Nishimori, Kota Kodama, Haruhiro Higashida

Journal of neuroendocrinology 32(4) e12815 2020年4月査読有り
One Single Nucleotide Polymorphism of the TRPM2 Channel Gene Identified as a Risk Factor in Bipolar Disorder Associates with Autism Spectrum Disorder in a Japanese Population.

Naila Al Mahmuda, Shigeru Yokoyama, Toshio Munesue, Kenshi Hayashi, Kunimasa Yagi, Chiharu Tsuji, Haruhiro Higashida

Diseases (Basel, Switzerland) 8(1) 2020年2月7日査読有り
Characteristics of university students supported by counseling services: Analysis of psychological tests and pulse rate variability.

Yumi Adachi, Hiroaki Yoshikawa, Shigeru Yokoyama, Kazuo Iwasa

PloS one 15(8) e0218357 2020年査読有り
CD38, CD157, and RAGE as Molecular Determinants for Social Behavior.

Haruhiro Higashida, Minako Hashii, Yukie Tanaka, Shigeru Matsukawa, Yoshihiro Higuchi, Ryosuke Gabata, Makoto Tsubomoto, Noriko Seishima, Mitsuyo Teramachi, Taiki Kamijima, Tsuyoshi Hattori, Osamu Hori, Chiharu Tsuji, Stanislav M Cherepanov, Anna A Shabalova, Maria Gerasimenko, Kana Minami, Shigeru Yokoyama, Sei-Ichi Munesue, Ai Harashima, Yasuhiko Yamamoto, Alla B Salmina, Olga Lopatina

Cells 9(1) 2019年12月25日査読有り
Synthesis of oxytocin derivatives lipidated via a carbonate or carbamate linkage as a long-acting therapeutic agent for social impairment-like behaviors.

Stanislav M Cherepanov, Risako Miura, Anna A Shabalova, Wataru Ichinose, Shigeru Yokoyama, Hayato Fukuda, Mizuki Watanabe, Haruhiro Higashida, Satoshi Shuto

Bioorganic & medicinal chemistry 27(15) 3358-3363 2019年8月1日査読有り
Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.

Wataru Ichinose, Stanislav M Cherepanov, Anna A Shabalova, Shigeru Yokoyama, Teruko Yuhi, Hiroaki Yamaguchi, Ayu Watanabe, Yasuhiko Yamamoto, Hiroshi Okamoto, Shinichi Horike, Junpei Terakawa, Takiko Daikoku, Mizuki Watanabe, Nariyasu Mano, Haruhiro Higashida, Satoshi Shuto

Journal of medicinal chemistry 62(7) 3297-3310 2019年4月11日査読有り