SEIKI Motoharu

J-GLOBAL         Last updated: Jul 14, 2017 at 02:53
 
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Name
SEIKI Motoharu
Affiliation
Kanazawa University
Section
Institute of Medical,Pharmaceutical and Health Sciences Faculty of Medicine
Job title
Professor
Degree
Medical Science(Kanazawa University)

Research Areas

 
 

Academic & Professional Experience

 
1982
 - 
1985
Cancer Institute, Tokyo
 
1988
 - 
1997
Professor, Cancer Research Institute, Kanazawa University
 
1997
 - 
2014
Professor, Institute of Medical Science, The University of Tokyo
 
2014
 - 
2016
Specially pointed professor, Kochi University
 
2015
 - 
2018
Specially appointed professor, Kanazawa University
 

Awards & Honors

 
Oct 2013
Discovery of membrane-type 1 matrix metalloproteinase (MT1-MMP) and establishment of a novel research field involving cancer invasion and metastasis, Tomizo Yoshida Award, Japanese Cancer Association
 

Published Papers

 
Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R
Molecular cancer research : MCR   11 628-637   Jun 2013   [Refereed]
Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ
Developmental cell   25 402-416   May 2013   [Refereed]
Watanabe A, Hoshino D, Koshikawa N, Seiki M, Suzuki T, Ichikawa K
PLoS computational biology   9 e1003086   May 2013   [Refereed]
Hoshiko S, Kawaguchi M, Fukushima T, Haruyama Y, Yorita K, Tanaka H, Seiki M, Inatsu H, Kitamura K, Kataoka H
Cancer research   73 2659-2670   Apr 2013   [Refereed]
Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell MJ
Development (Cambridge, England)   140 343-352   Jan 2013   [Refereed]

Misc

 
Expression of type IV collagenases in human tumor cell lines that can from liver colonies in chick embryo.
Int. J. Cancer.   56,46-51    1994
Two distinct regions from a functional activation domain of the HTLV-1 trans-activator Tax1.
ONCOGENE   9,337-340    1994
v-Src activates the transcription of 92-Da type IV collagenase gene througth the AP-I site and the GT box homologous to retinoblastoma control elements(RCES).
J. Biol. Chem.   268,23460-23468    1993
Tissue inhibitor of metalloproteinases-I(TIMP-I)is a negative regulator of the metastatic ability of a human gastric cancer cell line, KKLS, in the chick embryo.
Cancer Res.   53,1397-1402    1993
Regulatory mechanism of 92-kDa type IV collagenase gene expression which is associated with invasiveness of tumor Cells.
Oncogene   8,395-405    1993

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(特定領域研究)
Project Year: 2004 - 2009    Investigator(s): Yoshimi TAKAI
A number of previous studies revealed the properties of cancer cells at the levels of genes and cells, contributing to the elucidation of the mechanisms by which cancer is a life-threatening disease. Based on accumulating lines of evidence concern...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(A))
Project Year: 2003 - 2005    Investigator(s): Motoharu SEIKI
We established a transfected human squemous carcinoma A431 cell line m which expression of FLAG-tagged MT1-MMP or FIAG-tagged integrins beta-1 is inducible. We set up conditions to isolate the FLAG-tagged MT1-MMP including various associating mole...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2001 - 2002    Investigator(s): Motoharu SEIKI
In our murine strain deficient in MT1-MMP gene expression, the bone morphogenesis was severely impaired, consistent with the past reports. Next question would be an address to know which cell lineages in bone tissue are responsible to work with ex...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(国際学術研究, 基盤研究(B))
Project Year: 1998 - 1999    Investigator(s): Motoharu SEIKI
(1) Malignant melanoma cells degrade gelatin gel beneath the cells by extending protrusions called invadpodia. We foud that MT1-MMP localizes on the invadpodia. To monitor the cell surface. MT1-MMP more easily, we made MT1MMP fused with GFP and ex...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 1998 - 1999    Investigator(s): Motoharu SEIKI
Matrix metalloproteinases (MMPs) degrade extracellular matrix (ECM) and support cancer cell invasion in tissue, and eventually metastasis formation. Inhibition of MMP activity is expected to prevent cancer cell growth, invasion and metastasis, and...