MUKAIDA NAOFUMI

Last updated: Nov 25, 2019 at 18:05

Name	MUKAIDA NAOFUMI
E-mail	mukaidastaff.kanazawa-u.ac.jp
Affiliation	Kanazawa University
Section	Cancer Research Institute
Job title	Professor
ORCID ID	0000-0002-4193-1851

Research Interests

Pro-inflammatory cytokines(3)

Research Areas

Basic medicine / Immunology /
Boundary medicine / Laboratory medicine /
Basic medicine / Experimental pathology /
Basic medicine / Pathological medical chemistry /

Academic & Professional Experience

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Jan 2000

Cancer Research Instittue, Kanazawa University

May 1992

Dec 1999

Cancer Research Institute, Kanazawa University

Apr 1992

Apr 1993

School of Allied Health Sciences, Tokyo Medical and Dental University

Nov 1990

Mar 1991

Med. Technol. School, School Med., Tokyo Medical and Dental University

May 1988

Oct 1990

Laboratory of Molecular Bioregulation, National Caner Institute, USA

Education

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1980

Hokkaido University

Committee Memberships

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2008

Japanese Cancer Association

2003

Japanese Society of Metastasis Research

2008

Japanse Society of Inflammation and Regneration

2008

-: Japanese Cancer Association　

2003

-: Japanese Society of Metastasis Research　

Published Papers

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CCL2-Mediated Reversal of Impaired Skin Wound Healing in Diabetic Mice by Normalization of Neovascularization and Collagen Accumulation

Ishida Y, Kuninaka Y, Nosaka M, Furuta M, Kimura A, Taruya A, Yamamoto H, Shimada E, Akiyama M, Mukaida N, Kondo T.

Journal of Investigative Dermatology 139(12) 2517-2527.e5 2019 [Refereed]

Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells

Mukaida N, Nosaka T, Nakamoto Y, Baba T.

International Journal of Molecular Sciences 20(1) Dec 2018 [Refereed]

Regulation of stimulus-induced interleukin-8 gene transcription in human adrenocortical carcinoma cells – Role of AP-1 and NF-κB

Thiel G, Ulrich M, Mukaida N, R{ö}ssler O.G.

Cytokine 126 2020 [Refereed]

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

Ji D.X, Yamashiro L.H, Chen K.J, Mukaida N, Kramnik I, Darwin K.H, Vance R.E.

Nature Microbiology 2019 [Refereed]

IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer

Song Y, Ji B, Jiang C.-X, Chen Z.-M, Yao N.-H, Mukaida N, Huang H.

Pathology Research and Practice 215(12) 2019 [Refereed]

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike S.-I, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N.

Oncogene 38(14) 2464-2481 2019 [Refereed]

Retinoblastoma inactivation induces a protumoral microenvironment via enhanced CCL2 secretion

Li F, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada N, Nishimoto Y, Muranaka H, Nagatani N, Suzuki M, Masuda S, Thai T.C, Nishiuchi T, Tanaka T, Barbie D.A, Mukaida N, Takahashi C.

Cancer Research 79(15) 3903-3915 2019 [Refereed]

Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B₄.

Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida N

Journal of immunology (Baltimore, Md. : 1950) 200(5) 1839-1852 Mar 2018 [Refereed]

Resveratrol stimulation induces interleukin-8 gene transcription via NF-κB.

Thiel G, Ulrich M, Mukaida N, Rössler OG

Pharmacological research 134 238-245 Aug 2018 [Refereed]

Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.

Sasaki S, Baba T, Muranaka H, Tanabe Y, Takahashi C, Matsugo S, Mukaida N

Molecular cancer therapeutics 17(7) 1515-1525 Jul 2018 [Refereed]

Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.

Mukaida N, Nakamoto Y

World journal of gastroenterology 24(17) 1839-1858 May 2018 [Refereed]

Protective Roles of Interferon-γ in Cardiac Hypertrophy Induced by Sustained Pressure Overload.

Kimura A, Ishida Y, Furuta M, Nosaka M, Kuninaka Y, Taruya A, Mukaida N, Kondo T

Journal of the American Heart Association 7(6) Mar 2018 [Refereed]

Stimulation of transient receptor potential M3 (TRPM3) channels increases interleukin-8 gene promoter activity involving AP-1 and extracellular signal-regulated protein kinase.

Rubil S, Lesch A, Mukaida N, Thiel G

Cytokine 103 133-141 Mar 2018 [Refereed]

Contribution of the TNF-α (tumor necrosis factor-α)-TNFrp55 (tumor necrosis factor receptor p55) axis in the resolution of venous thrombus

Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Taruya A, Furuta M, Mukaida N, Kondo T.

Arteriosclerosis, Thrombosis, and Vascular Biology 38(11) 2638-2650 2018 [Refereed]

Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration.

Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Hemmi H, Sasaki I, Kaisho T, Mukaida N, Kondo T

Scientific reports 7(1) 16833 Dec 2017 [Refereed]

Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression.

Akai Y, Sadanari H, Takemoto M, Uchide N, Daikoku T, Mukaida N, Murayama T

Antiviral research 148 15-19 Dec 2017 [Refereed]

Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia.

Mukaida N, Tanabe Y, Baba T

International journal of molecular sciences 18(8) Aug 2017 [Refereed]

DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization.

Zhuge F, Ni Y, Nagashimada M, Nagata N, Xu L, Mukaida N, Kaneko S, Ota T

Diabetes 65(10) 2966-2979 Oct 2016 [Refereed]

Gemcitabine induces cell senescence in human pancreatic cancer cell line

Song Y, Baba T, and Mukaida N

Biochem Biophys Res Commun 477(3) 515-519 Aug 2016 [Refereed]

Essential roles of the interaction between cancer cell-derived chemokine, CCL4, and intra-bone CCR5-expressing fibroblasts in breast cancer bone metastasis

Sasaki S, Baba T, Nishimura T, Hayakawa Y, Hashimoto S, Gotoh N, and Mukaida N

Cancer Letters 378(1) 23-32 Aug 2016 [Refereed]

Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation.

Tanabe Y, Sasaki S, Mukaida N, and Baba T

Oncotarget 7(30) 48335-48345 Jul 2016 [Refereed]

Fibroblasts, an inconspicuous but essential player in colon cancer development and progression.

Mukaida N, Sasaki S

World journal of gastroenterology 22(23) 5301-5316 Jun 2016 [Refereed]

MIP-1alpha/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice

Baba T, Tanabe Y, Yoshikawa S, Yamanishi Y, Morishita S, Komatsu N, Karasuyama H, Hirao A, and Mukaida N.

Blood 127(21) 2607-2617 May 2016 [Refereed]

Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent.

Nakano H, Hasegawa T, Saito N, Furukawa K, Mukaida N, Kojima H, Okabe T, Nagano T

Bioorganic & medicinal chemistry letters 25(24) 5687-5693 Dec 2015 [Refereed]

High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites.

Naito T, Baba T, Takeda K, Sasaki S, Nakamoto Y, Mukaida N

Cancer letters 366(1) 93-99 Sep 2015 [Refereed]

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine.

Liang C, Yu XJ, Guo XZ, Sun MH, Wang Z, Song Y, Ni QX, Li HY, Mukaida N, Li YY

Oncotarget 6(16) 14440-14455 Jun 2015 [Refereed]

Gemcitabine-induced CXCL8 expression counteracts its action by inducing tumor neovascularization

Song Y, Baba T, Li Y-Y, Furukawa K, Tanabe Y, Matsugo S, Sasaki S, and Mukaida N.

Biochem Biophys Res Commun 458(2) 341-346 Mar 2015 [Refereed]

Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice.

Hata R, Izukuri K, Kato Y, Sasaki S, Mukaida N, Maehata Y, Miyamoto C, Akasaka T, Yang X, Nagashima Y, Takeda K, Kiyono T, Taniguchi M

Scientific reports 5 9083 Mar 2015 [Refereed]

Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma

Mazzocca Antonio, Dituri Francesco, De Santis Flavia, Filannino Addolorata, Lopane Chiara, Betz Regina C, Li Ying-Yi, Mukaida Naofumi, Winter Peter, Tortorella Cosimo, Giannelli Gianluigi, Sabba Carlo

Cancer Research 75(3) 532-543 Feb 2015 [Refereed]

High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-posisitve T cells into tumor sites

Naito T, Baba T, TakedaK, Sasaki S, Nakamoto Y, Mukaida N

Cancer Letters 366(1) 93 2015

Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells.

Tabata S, Ikeda R, Yamamoto M, Shimaoka S, Mukaida N, Takeda Y, Yamada K, Soga T, Furukawa T, Akiyama S

Oncotarget 5(21) 10473-10485 Nov 2014 [Refereed]

Human cytomegalovirus replication supported by virus-induced activation of CCL2-CCR2 interactions

Murayama Tsugiya, Kikuchi Marie, Miita Takaki, Yamada Rie, Matsubara Keiko, Sadanari Hidetaka, Mukaida Naofumi

Biochemical and Biophysical Research Communications 453(3) 321-325 Oct 2014 [Refereed]

Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice.

269. Sasaki S, Baba T, Shinagwa K, Matsushima K, and Mukaida N

International Journal of Cancer 135(6) 1297-1306 Mar 2014 [Refereed]

Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses.

268. Hamano R, Baba T, Sasaki S, Tomaru U, Ishizu A, Kawano M, Yamagishi M, and Mukaida N

European Journal of Immunology 44(4) 1005 Feb 2014

Absence of IL-6 accelerates thrombus formation through reduced MMPs and uPA expression in murine deep vein thrombosis model

Nosaka Mizuho, Ishida Yuko, Kimura Akihiko, Kuninaka Yumi, Mukaida Naofumi, Kondo Toshikazu

Cytokine 70(1) 61 2014 [Refereed]

Chemokines in Cancer Development and Progression and Their Potential as Targeting Molecules for Cancer Treatment

Mukaida Naofumi, Sasaki So-ichiro, Baba Tomohisa

Mediators of Inflammation 2014 [Refereed]

Cytotoxic CD4(+) Cells Play a Pivotal Role in Cyclophosphamide-Mediated Cytotoxicity against Hepatoma without Antigen Priming

Naito Tatsushi, Baba Tomohisa, Mukaida Naofumi, Nakamoto Yasunari

Hepatology 60 497A 2014 [Refereed]

Efficient generation of highly immunocompetent dendritic cells from peripheral blood of patients with hepatitis C virus-related hepatocellular carcinoma

Kitahara Masaaki, Mizukoshi Eishiro, Nakamoto Yasunari, Mukaida Naofumi, Matsushima Kouji, Kaneko Shuichi

International Immunopharmacology 21(2) 346-353 2014 [Refereed]

Intestinal microbiota: unexpected alliance with tumor therapy

Mukaida Naofumi

Immunotherapy 6(3) 231-233 2014 [Refereed]

LPA6 promotes growth and tumorigenicity of hepatocellular carcinoma via activation of PIM-3 proto-oncogene kinase

Lopane C, Goffredo V, Dituri F, De Santis F, Filannino A, Betz R. C, Li Y. Y, Mukaida N, Winter P, Tortorella C, Giannelli G, Sabba C, Mazzocca A.

European Journal of Cancer 50 161 2014 [Refereed]

Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression

Li Ying-Yi, Mukaida Naofumi

World Journal of Gastroenterology 20(28) 9392-9404 2014 [Refereed]

MIP-1alpha/CCL3-mediated maintenance of leukemia initiating cells in the initiation process of chronic myeloid leukemia.

265. Baba T, Naka K, Morishita S, Komatsu N, Hirao A, and Mukaida N

Journal of Experimental Medicine 210(12) 2661 Nov 2013

Inflammatory monocytes recruited to allergic skin acquire anti-inflammatory M2 phenotype via basophil-derived IL-4.

Egawa M, Mukai K, Yoshikawa S, Iki M, Mukaida N, Kawano Y, Minegishi Y, and Karasuyama H.

IMMUNITY 38(3) 570 Mar 2013

IFN-gammais protective in cisplatin-induced renal injury by enhancing autophagic flux.

Kimura A, Ishida, Y, Inagaki M, Nakamura Y, Sanke T, Mukaida N, and Kondo T

KIDNEY INTERNATIONAL 82(10) 1093 Oct 2012

CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status.

Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, Takamura T, Yamamoto H, Miyamoto K, Ginsberg HN, Mukaida N, Kaneko S, and Ota T.

DIABETES 61(7) 1680 Jul 2012

Critical role of TNF-alpha-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization.

Lu P, Li L, Liu G, Baba T, Ishida Y, Nosaka M, Kondo T, Xhang X, and Mukaida N

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53(7) 3516 Jul 2012

Chemokines in tumor development and progression.

Mukaida N and Baba T

EXPERIMENTAL CELL RESEARCH 318(2) 95 Feb 2012

Identification of a phenanthrene derivative as a potent anti-cancer drug with Pim kinase inhibitory activities.

Wang Y-Y, Taniguchi T, Baba T, Li Y-Y, Ishibashi H, and Mukaida N.

Cancer Science 13(1) 107 Jan 2012

Pivotal role of the CCL5-CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing.

Ishida Y, Kimura A, Kuninaka Y, Inui M, Matsushima K, Mukaida N, and Kondo T

JOURNAL OF CLINICAL INVESTIGATION 122(2) 711 Jan 2012

Roles of Pim-3, a novel survival kinase, in tumorigenesis.

Mukaida N,Wang YY,Li YY

Cancer Science 102(8) 1437-42 Aug 2011

Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice.

Nosaka M,Ishida Y,Kimura A,Kuninaka Y,Inui M,Mukaida N,Kondo T

J Clin Invest 121(7) 2911-20 Jul 2011

Absence of IFN-gamma accelerates thrombus resolution through enhancing MMP-9 and VEGF expression in mice.

Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Inui M, Mukaida N, and Kondo T

JOURNAL OF CLINICAL INVESTIGATION 121(7) 497 Jul 2011

Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney.

Shimizu K,Furuichi K,Sakai N,Kitagawa K,Matsushima K,Mukaida N,Kaneko S,Wada T

Hypertens Res 34(6) 747-52 Jun 2011

Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization.

Nakamoto Y,Mizukoshi E,Kitahara M,Arihara F,Sakai Y,Kakinoki K,Fujita Y,Marukawa Y,Arai K,Yamashita T,Mukaida N,Matsushima K,Matsui O,Kaneko S

Clin Exp Immunol 163(2) 165-77 Feb 2011

Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression.

Inui M,Ishida Y,Kimura A,Kuninaka Y,Mukaida N,Kondo T

J Immunol 186(1) 423-31 Jan 2011

Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice.

Fujii H,Baba T,Ishida Y,Kondo T,Yamagishi M,Kawano M,Mukaida N

Arthritis Rheum 63(1) 96-106 Jan 2011

Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice.

Kakinoki K,Nakamoto Y,Kagaya T,Tsuchiyama T,Sakai Y,Nakahama T,Mukaida N,Kaneko S

J Gene Med 12(12) 1002-13 Dec 2010

Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver.

Wu Y,Wang YY,Nakamoto Y,Li YY,Baba T,Kaneko S,Fujii C,Mukaida N

ONCOGENE 29(15) 2228-37 Aug 2010

Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha.

Iida N,Nakamoto Y,Baba T,Nakagawa H,Mizukoshi E,Naito M,Mukaida N,Kaneko S

Cancer Res 70(16) 6556-65 Aug 2010

Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice.

Kostadinova FI,Baba T,Ishida Y,Kondo T,Popivanova BK,Mukaida N

J Leukoc Biol 88(1) 133-43 Jul 2010

Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability.

Li YY,Wang YY,Taniguchi T,Kawakami T,Baba T,Ishibashi H,Mukaida N

Int J Cancer 127(2) 474-84 Feb 2010

The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.

Kimura A,Ishida Y,Wada T,Hisaoka T,Morikawa Y,Sugaya T,Mukaida N,Kondo T

Am J Pathol 176(1) 40-50 Jan 2010

Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist.

Lu P,Li L,Liu G,Zhang X,Mukaida N

Invest Ophthalmol Vis Sci 50(10) 4761-8 Oct 2009

Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice.

Popivanova BK,Kostadinova FI,Furuichi K,Shamekh MM,Kondo T,Wada T,Egashira K,Mukaida N

Cancer Res 69(19) 7884-92 Oct 2009

Nitric oxide-induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells.

Seo JY,Yu JH,Lim JW,Mukaida N,Kim H

J Physiol Pharmacol 60 Suppl 7 101-6 Sep 2009

Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner.

Baba T,Nakamoto Y,Mukaida N

JOURNAL OF IMMUNOLOGY 183(5) 3053-63 Aug 2009

Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization.

Lu P,Li L,Liu G,van Rooijen N,Mukaida N,Zhang X

Cornea 28(5) 562-9 May 2009

Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.

Li YY,Wu Y,Tsuneyama K,Baba T,Mukaida N

Cancer Sci 100(3) 396-404 Mar 2009

Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.

Ishibe T,Kimura A,Ishida Y,Takayasu T,Hayashi T,Tsuneyama K,Matsushima K,Sakata I,Mukaida N,Kondo T

Lab Invest 89(1) 68-79 Jan 2009

CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fiborblasts, and promotes angiogenesis in murine lung metastasis process.

JOURNAL OF IMMUNOLOGY 181(9) 6384-6394 Nov 2008

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice

Sawanobori Y, Ueha S, Kurachi M, Shimaoka T, Talmadge JE, Abe J, Shono Y, Kitabatake M, Kakimi K, Mukaida N, and Matsushima K

BLOOD 111(12) 5457-5466 Jun 2008

Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation

Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, Azuma T, Yamaoka Y, Sap J, Yamasaki E, Yashiro K, Moss J, and Hirayama T

JOURNAL OF IMMUNOLOGY 180(7) 5017-5027 Apr 2008

Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced anti-angiogenic factor expression

Lu P, Li L, Kuno K, Wu Y, Baba T, Li Y-Y, Zhang X, and Mukaida N.

JOURNAL OF IMMUNOLOGY 180(6) 4283-4291 Mar 2008

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.

Popivanova BK, Kitamura K, Wu Y, Kondo T, Kagaya T, Kaneko S, Oshima M, Fujii C, and Mukaida N.

JOURNAL OF CLINICAL INVESTIGATION 118(2) 560-570 Feb 2008

IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappaB activation.

JOURNAL OF IMMUNOLOGY 178(11) 7385-7394 Jun 2007

Prolonged, NK cell-mediated antitumor effects of suicide gene therapy combined with monocyte chemoattractant protein-1 against hepatocellular carcinoma

Tsuchiyama T, Nakamoto Y, Sakai Y, Marukawa Y, Kitahara M, Mukaida N, and Kaneko S.

JOURNAL OF IMMUNOLOGY 178(1) 574-583 Jan 2007

Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulation of intrarenal multidrug resistance-associated protein 1 expression.

Kimura A, Ishida Y, Hayashi T, Wada T, Yokoyama H, Sugaya T, Mukaida N, and Kondo T

AMERICAN JOURNAL OF PATHOLOGY 169(4) 1118-1128 Oct 2006

Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates Bad to block Bad-mediated apoptosis in human pancreatic cancer cell lines

Li Y-Y, Popivanova BK, Nagai Y, Ishikura H, Fujii C, and Mukaida N

CANCER RESEARCH 66(13) 6741-6747 Jul 2006

Absence of IL-1 receptor antagonist impaired wound healing along with aberrant NF-kappaB activation and a reciprocal suppression of TGF-beta signal pathway

Ishida Y, Kondo T, Kimura A, Matsushima K, and Mukaida, N

JOURNAL OF IMMUNOLOGY 176(9) 1028-1038 May 2006

Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.

Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T, and Mukaida N

EUROPEAN JOURNAL OF IMMUNOLOGY 36(4) 1028-1038 Apr 2006

Aberrant expression of Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines

INTERNATIONAL JOURNAL OF CANCER 114 209-218 2005

Essential involvement of INF-gamma in Clostidium difficile toxin A-induced enteritis

JOURNAL OF IMMUNOLOGY 172(5) 3018-3025 Mar 2004

The essential involvement of cross-talk betweeen IFN-gamma and TGF-beta in the skin wound healing process

JOURNAL OF IMMUNOLOGY 172(3) 1848-1855 Feb 2004

Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1, in human hepatomas.

AMERICAN JOURNAL OF PATHOLOGY 162(4) 1249-1258 Apr 2003

NOD/SCID repopulating cells but not LTC-IC are enriched in human CD34+ cells expressing the CCR1 chemokine receptor

LEUKEMIA 15 1092-1101 Jul 2001

IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2

JOURNAL OF IMMUNOLOGY 167 366-374 Jul 2001

Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response

JOURNAL OF VIROLOGY 75 6095-6106 Jul 2001

IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas

CLINICAL CANCER RESEARCH 7 1812-1820 Jun 2001

Differential regulation of chemokine gene expression by 15-deoxy-delta 12,14 prostaglandin J2

JOURNAL OF IMMUNOLOGY 166 7104-7111 Jun 2001

CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 107 353-358 Feb 2001

Nuclear factor-kappaB-dependent expression of metastasis suppressor KAI1/CD82 gene in lung cancer cell lines expressing mutant p53

CANCER RESEARCH 61 673-678 Jan 2001

Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY 122 207-211 Dec 2000

The immediate early gene 1 product of human cytomegalovirus is sufficient for up-regulation of interleukin-8 gene expression.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279 298-304 Dec 2000

PEA3 and AP-1 are required for constitutive IL-8 gene expression in hepatoma cells.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 279 166-171 Dec 2000

Natural killer cell-dependent suppression of systemic spread of human lung adenocarcinoma cells by monocyte chemoattractant protein-1 gene transfection in severe combined immunodeficient mice

CANCER RESEARCH 60 7002-7007 Dec 2000

Lipopolysaccharide-induced cytokine and receptor expression and neutrophil infiltration in the liver of osteopetrosis (op/op) mutant mice

LIVER 20 465-474 Dec 2000

Up-regulation of monocye chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy

KIDNEY INTERNATIONAL 58 1492-1499 Oct 2000

A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 11 1534-1541 Aug 2000

Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8

CLINICAL CANCER RESEARCH 6 2735-2740 Jul 2000

Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases

AMERICAN JOURNAL OF NEPHROLOGY 20 291-299 Jul 2000

Misc

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CANCER RESEARCH 66(13) 6741-6747 2006

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis.

JOURNAL OF CLINICAL INVESTIGATION 118(2) 560-570 2008

CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fiborblasts, and promotes angiogenesis in murine lung metastasis process.

JOURNAL OF IMMUNOLOGY 181(9) 6384-6394 2008

Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation

INTERNATIONAL JOURNAL OF HEMATOLOGY 72(4) 391-398 2000

Interleukin-8 (IL-8) and monocyte chemotactic and activating factor (MCAF/MCP-1), chemokines essentially involved in inflammatory and immune reactions

Cytokine and Growth Factor Review 9(1) 9-23 1998

Books etc

Plain Text

The Cytokine Handbook, 4th Edition

Elsevier Science Ltd Aug 2003 ISBN:0-12-689663-1

Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages, and neovascularization.

Yang X, Lu P, Ishida Y, Kuziel WA, Fujii C, and Mukaida, N.

Jan 2006

Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression.

Yang X, Lu P, Fujii C, Nakamoto Y, Gao J-L, Kaneko S, Murphy PM, and Mukaida N.

Apr 2006

Association Memberships

Japanese Cancer Association(344) , American Association of Immunologists(26) , American Society of Investigative Pathology(2) , Japanese Society of Metastasis Research(1) , Japanse Society of Inflammation and Regneration(1)

Patents

Plain Text

2008-160878 : Stemonamide synthesis intermediates and pharmaceutical composition for prevention and/or treatment of cancer