論文

査読有り 国際誌
2016年11月

Atypical development of the central auditory system in young children with Autism spectrum disorder.

Autism research : official journal of the International Society for Autism Research
  • Yuko Yoshimura
  • ,
  • Mitsuru Kikuchi
  • ,
  • Hirotoshi Hiraishi
  • ,
  • Chiaki Hasegawa
  • ,
  • Tetsuya Takahashi
  • ,
  • Gerard B Remijn
  • ,
  • Manabu Oi
  • ,
  • Toshio Munesue
  • ,
  • Haruhiro Higashida
  • ,
  • Yoshio Minabe
  • ,
  • Haruyuki Kojima

9
11
開始ページ
1216
終了ページ
1226
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/aur.1604

The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child-customized magnetoencephalography. A total of 35 young TD children (32-121 months of age) and 35 children with autism spectrum disorder (ASD) (38-111 months of age) participated in this study. This is the first report to demonstrate an inverted U-shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age-related distribution of auditory brain responses in 3- to 9-year-old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition. Autism Res 2016, 9: 1216-1226. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

リンク情報
DOI
https://doi.org/10.1002/aur.1604
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26808455
URL
http://europepmc.org/abstract/med/26808455
URL
http://orcid.org/0000-0002-1779-0606
ID情報
  • DOI : 10.1002/aur.1604
  • ISSN : 1939-3792
  • ORCIDのPut Code : 25197182
  • PubMed ID : 26808455

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