原明 (Akira Hara) - マイポータル

基本情報

所属: 岐阜大学医学系研究科医科学専攻腫瘍制御学講座腫瘍病理学分野教授
: 医学系研究科教授
: 医学部附属病院部長・センター長等（医学部附属病院）

学位: 医学博士(岐阜大学)

J-GLOBAL ID: 200901014803923107
researchmap会員ID: 1000022200

腫瘍発生メカニズムの解明および予防／１.腫瘍発生における遺伝子変化の解明２.幹細胞と腫瘍発生のメカニズム解明／神経変性メカニズムの解明および神経再生／１.脳虚血による海馬神経細胞変性２.海馬神経細胞アポトーシスの際の形態３.網膜神経細胞変性機序４.網膜神経細胞再生と幹細胞の腫瘍化／遺伝子改変動物による病理病態解析／１.遺伝子欠損マウスを利用した腫瘍発生、神経変性などの病態解明２.遺伝子発現誘導マウスを利用した腫瘍発生、神経変性などの病態解明／病理組織学的研究／遺伝子改変動物研究／がん幹細胞研究／腫瘍病理学一般、幹細胞研究、がん細胞培養、ES細胞／病理診断、免疫組織染色、蛍光組織染色、がん細胞培養

研究キーワード

研究分野

経歴

受賞

2000年3月

WHOがん研究所（IARC） Special Training Award 2000
1991年

岐阜医学奨励賞

論文

Aberrant promoter hypermethylation of the CHFR gene in oral squamous cell carcinomas

Seiji Baba, Akira Hara, Keizo Kato, Nguyen Khanh Long, Yuichiro Hatano, Masashi Kimura, Yukio Okano, Yasuhiro Yamada, Toshiyuki Shibata

ONCOLOGY REPORTS 22(5) 1173-1179 2009年11月
Spatiotemporal expression of Hsp20 and its phosphorylation in hippocampal CA1 pyramidal neurons after transient forebrain ischemia

Masayuki Niwa, Akira Hara, Ayako Taguchi, Hitomi Aoki, Osamu Kozawa, Hideki Mori

NEUROLOGICAL RESEARCH 31(7) 721-727 2009年9月
Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes

Hitomi Aoki, Yasuhiro Yamada, Akira Hara, Takahiro Kunisada

DEVELOPMENT 136(15) 2511-2521 2009年8月
Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus

Seiji Baba, Yasuhiro Yamada, Yuichiro Hatano, Yasuo Miyazaki, Hideki Mori, Toshiyuki Shibata, Akira Hara

CANCER SCIENCE 100(7) 1186-1191 2009年7月
Marked increases in hippocampal neuron indoleamine 2, 3-dioxygenase via IFN-γ-independent pathway following transient global ischemia inmouse.

Hoshi M

Neurosci Res 63:194-198, 2009 63(3) 194-198 2009年3月
Upregulation of indoleamine 2,3-dioxygenase in hepatocyte during acute hepatitis caused by hepatitis B virus-specific cytotoxic T lymphocytes in vivo

Naoki Iwamoto, Hiroyasu Ito, Kazuki Ando, Tetsuya Ishikawa, Akira Hara, Ayako Taguchi, Kuniaki Saito, Masao Takemura, Michio Imawari, Hisataka Moriwaki …

LIVER INTERNATIONAL 29(2) 277-283 2009年2月
Chemopreventive effects of fermented brown rice and rice bran against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in female A/J mice

Suphot Phuttraphadoong, Yasuhiro Yamada, Akihiko Hirata, Hiroyuki Tomita, Ayako Taguchi, Akira Hara, Porn-Ngam Limtrakul, Teruaki Iwasaki, Hiroshi Kobayashi, Hideki Mori

ONCOLOGY REPORTS 21(2) 321-327 2009年2月
In vitro and in vivo differentiation of human embryonic stem cells into retina-like organs and comparison with that from mouse pluripotent epiblast stem cells.

Aoki H

Dev Dyn 238 2266-2279 2009年1月1日
Hypermethylation of the RECK gene predicts poor prognosis in oral squamous cell carcinomas

Nguyen Khanh Long, Keizo Kato, Tomomi Yamashita, Hiroki Makita, Makoto Toida, Daijiro Hatakeyama, Akira Hara, Hideki Mori, Toshiyuki Shibata

ORAL ONCOLOGY 44(11) 1052-1058 2008年11月
Iris as a recipient tissue for pigment cells: Organized in vivo differentiation of melanocytes and pigmented epithelium derived from embryonic stem cells in vitro

Hitomi Aoki, Akira Hara, Tsutomu Motohashi, Huayue Chem, Takahiro Kunisada

DEVELOPMENTAL DYNAMICS 237(9) 2394-2404 2008年9月
Neuron-like differentiation and selective ablation of undifferentiated embryonic stem cells containing suicide gene with Oct-4 promoter

Akira Hara, Hitomi Aoki, Ayako Taguchi, Masayuki Niwa, Yasuhiro Yamada, Takahiro Kunisada, Hideki Mori

STEM CELLS AND DEVELOPMENT 17(4) 619-627 2008年8月
Effects of green tea polyphenol on methylation status of RECK gene and cancer cell invasion in oral squamous cell carcinoma cells

K. Kato, N. K. Long, H. Makita, M. Toida, T. Yamashita, D. Hatakeyama, A. Hara, H. Mori, T. Shibata

BRITISH JOURNAL OF CANCER 99(4) 647-654 2008年8月
Metallothionein-3（GIF） is expressed in the brain and various peripheral organs of the rat.

Hozumi I

Neurosci Lett 438(1) 54-58 2008年6月
Localization and spatiotemporal expression of IDO following transient forebrain ischemia in gerbils

Ayako Taguchi, Akira Hara, Kuniaki Saito, Masato Hoshi, Masayuki Niwa, Mitsuru Seishima, Hideki Mori

BRAIN RESEARCH 1217 78-85 2008年6月
Further upregulation of beta-catenin/Tcf transcription is involved in the development of macroscopic tumors in the colon of Apc(Min/+) mice

Takeru Oyama, Yasuhiro Yamada, Kazuya Hata, Hiroyuki Tomita, Akihiro Hirata, HongQiang Sheng, Akira Hara, Hitomi Aoki, Takahiro Kunisada, Satoshi Yamashita …

CARCINOGENESIS 29(3) 666-672 2008年3月
Transplantation of cells from eye-like structures differentiated from embryonic stem cells in vitro and in vivo regeneration of retinal ganglion-like cells

Hitomi Aoki, Akira Hara, Masayuki Niwa, Tsutomu Motohashi, Takashi Suzuki, Takahiro Kunisada

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 246(2) 255-265 2008年2月
Transplantation of melanocytes into iris: Method for iris repigmentation.

Aoki H

Transplantation of melanocytes into iris: Method for iris repigmentation. 85 492-494 2008年1月1日
The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma.

Miyazaki Y

Int J Oncol 32 145-151 2008年1月1日
Preventive effect of fermented brown rice and rice bran on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats

Hiroyuki Tomita, Toshiya Kuno, Yasuhiro Yamada, Takeru Oyama, Nami Asano, Yasuo Miyazaki, Seiji Baba, Ayako Taguchi, Akira Hara, Teruaki Iwasaki …

ONCOLOGY REPORTS 19(1) 11-15 2008年1月
VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells

Naoki Oka, Akio Soeda, Akihito Inagaki, Masafumi Onodera, Hidekazu Maruyama, Akira Hara, Takahiro Kunisada, Hideki Mori, Toru Iwama

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 360(3) 553-559 2007年8月

もっとみる

MISC

275

The type III transporters (PiT-1 and PiT-2) are the major sodium-dependent phosphate transporters in the mice and human brains

Masatoshi Inden, Masaki Iriyama, Miho Zennami, Shin-ichiro Sekine, Akira Hara, Mitsunori Yamada, Isao Hozumi

BRAIN RESEARCH 1637 128-136 2016年4月
Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase

Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Hara, Akira Ikari

Biochemical and Biophysical Research Communications 472(1) 231-236 2016年3月
Galectin-3 expression in hippocampal CA2 following transient forebrain ischemia and its inhibition by hypothermia or antiapoptotic agents

Kenji Hisamatsu, Masayuki Niwa, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akihiro Hirata, Yuichiro Hatano, Hiroyuki Tomita, Akira Hara

NEUROREPORT 27(5) 311-317 2016年3月
Findings in Pancreatic MRI Associated With Pancreatic Fibrosis and HbA1c Values

Yoshifumi Noda, Satoshi Goshima, Kaori Tanaka, Shinji Osada, Hiroyuki Tomita, Akira Hara, Yukio Horikawa, Jun Takeda, Kimihiro Kajita, Haruo Watanabe …

JOURNAL OF MAGNETIC RESONANCE IMAGING 43(3) 680-687 2016年3月
Findings in Pancreatic MRI Associated With Pancreatic Fibrosis and HbA1c Values

Yoshifumi Noda, Satoshi Goshima, Kaori Tanaka, Shinji Osada, Hiroyuki Tomita, Akira Hara, Yukio Horikawa, Jun Takeda, Kimihiro Kajita, Haruo Watanabe …

JOURNAL OF MAGNETIC RESONANCE IMAGING 43(3) 680-687 2016年3月
Retinal cell degeneration in animal models

Masayuki Niwa, Hitomi Aoki, Akihiro Hirata, Hiroyuki Tomita, Paul G. Green, Akira Hara

International Journal of Molecular Sciences 17(1) 2016年1月15日
Aldehyde dehydrogenase 1A1 in stem cells and cancer

Hiroyuki Tomita, Kaori Tanaka, Takuji Tanaka, Akira Hara

Oncotarget 7(10) 11018-11032 2016年
Preventive effects of fermented brown rice and rice bran against N-nitrosobis (2-oxopropyl) amine‑induced pancreatic tumorigenesis in male hamsters

Toshiya Kuno, Satoru Takahashi, Hiroyuki Tomita, Kenji Hisamatsu, Akira Hara, Akihiro Hirata, Hiroshi Kobayashi, Hideki Mori

Oncology Letters 10(6) 3377-3384 2015年12月
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

Yoku Hayakawa, Hiroshi Ariyama, Jitka Stancikova, Kosuke Sakitani, Samuel Asfaha, Bernhard W. Renz, Zinaida A. Dubeykovskaya, Wataru Shibata, Hongshan Wang, Christoph B. Westphalen …

CANCER CELL 28(6) 800-814 2015年12月
Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily

Satoshi Endo, Misato Noda, Akira Ikari, Kenjiro Tatematsu, Ossama El-Kabbani, Akira Hara, Yukio Kitade, Toshiyuki Matsunaga

Journal of Biochemistry 158(5) 425-434 2015年11月
An autopsy report of acute myocardial infarction with hypertrophic obstructive cardiomyopathy-like heart

Hiroaki Ushikoshi, Hideshi Okada, Kentaro Morishita, Hajime Imai, Hiroyuki Tomita, Takahide Nawa, Kodai Suzuki, Haruka Ikeshoji, Hisaaki Kato, Takahiro Yoshida …

CARDIOVASCULAR PATHOLOGY 24(6) 405-407 2015年11月
Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers

Toshiyuki Matsunaga, Chihiro Kezuka, Yoshifumi Morikawa, Ayaka Suzuki, Satoshi Endo, Kazuhiro Iguchi, Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Ossama El-Kabbani …

Biological and Pharmaceutical Bulletin 38(9) 1309-1319 2015年9月1日
ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

Kaori Tanaka, Hiroyuki Tomita, Kenji Hisamatsu, Takayuki Nakashima, Yuichiro Hatano, Yoshiyuki Sasaki, Shinji Osada, Takuji Tanaka, Tatsuhiko Miyazaki, Kazuhiro Yoshida …

ONCOTARGET 6(28) 24722-24732 2015年9月
Inhibition of indoleamine 2,3-dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice

Manabu Takamatsu, Akihiro Hirata, Hirofumi Ohtaki, Masato Hoshi, Tatsuya Ando, Hiroyasu Ito, Yuichiro Hatano, Hiroyuki Tomita, Toshiya Kuno, Kuniaki Saito …

CANCER SCIENCE 106(8) 1008-1015 2015年8月
Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation

Yuichiro Hatano, Katsunori Semi, Kyoichi Hashimoto, Myeong Sup Lee, Akihiro Hirata, Hiroyuki Tomita, Toshiya Kuno, Manabu Takamatsu, Koji Aoki, Makoto M. Taketo …

CARCINOGENESIS 36(7) 719-729 2015年7月
Conditional Deletion of Kit in Melanocytes: White Spotting Phenotype Is Cell Autonomous

Hitomi Aoki, Hiroyuki Tomita, Akira Hara, Takahiro Kunisada

JOURNAL OF INVESTIGATIVE DERMATOLOGY 135(7) 1829-1838 2015年7月
Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells

Satoshi Endo, Ayako Nishiyama, Miho Suyama, Mayuko Takemura, Midori Soda, Huayue Chen, Kazuo Tajima, Ossama El-Kabbani, Yasuo Bunai, Akira Hara …

CHEMICO-BIOLOGICAL INTERACTIONS 234 282-289 2015年6月
Pre-stimulated Mice with Carbon Tetrachloride Accelerate Early Liver Regeneration After Partial Hepatectomy

Yuko Arioka, Hiroyasu Ito, Tatsuya Ando, Hideyuki Ogiso, Akihiro Hirata, Akira Hara, Mitsuru Seishima

DIGESTIVE DISEASES AND SCIENCES 60(6) 1699-1706 2015年6月
White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage

Hitomi Aoki, Akira Hara, Takahiro Kunisada

GENES TO CELLS 20(5) 439-449 2015年5月
Early microlesion of viral encephalitis confirmed by galectin-3 expression after a virus inoculation

Kazuhiro Kobayashi, Masayuki Niwa, Masato Hoshi, Kuniaki Saito, Kenji Hisamatsu, Yuichiro Hatano, Hiroyuki Tomita, Tatsuhiko Miyazaki, Akira Hara

NEUROSCIENCE LETTERS 592 107-112 2015年4月