SUZUKI Fumiaki

J-GLOBAL         Last updated: Dec 11, 2019 at 02:48
SUZUKI Fumiaki
Gifu University
Faculty of Applied Biological Sciences
(BLANK)(University of Tsukuba), (BLANK)(Kyoto University)


Biochmistry and strucural Biology of prorenin and renin-angiotensin system/Strucrual Biology of prorenin, and Biochemistry and MolBiol of angiogenesis and blood vessel formation, etc./Biochemistry of (pro)renin receptor/Investigation of role of prorenin associated with its receptor, and application of these studies./Biochemistry and Mol Biol. of vitellin blood vessel network durinng chick development./Evaluation of vitellin blood network in the chick as a research model of capillary network.

Research Areas


Academic & Professional Experience

Professor, Gifu University Faculty of Applied Biological Sciences
Gifu University, Research Assistant
Gifu University, Associate Professor
University Heidelberg, Alexander von Humboldt Research Fellow
University Tsukuba, Part-time Lecturer


Graduate School, Division of Agriculture, University of Tsukuba
Graduate School, Division of Agriculture, Kyoto University
Faculty of Agriculture, Gifu University

Published Papers

Suzuki Fumiaki(Fac. Applied Biol. Sci., Gifu University),Hayakawa Makoto(Fac. Applied Biol. Sci., Gifu University),Nakagawa Tsutomu(Fac. Applied Biol. Sci., Gifu University),Uddin M.Nasir(Fac. Applied Biol. Sci., Gifu University),Ebihara Akio(Fac. Applied Biol. Sci., Gifu University),Iwasawa Atsushi(Fac. Applied Biol. Sci., Gifu University),Ishida Yuichi(Tokiwa Chemical Co.),Murakami Kazuo(Inst. Appl. Biochem. Univ. Tsukuba)
278(25) 22217-22222   Jun 2003
Suzuki Fumiaki(Fac. Applied Biol. Sci., Gifu University),Murakami Kazuo(Inst. Appl. Biochem., Univ. Tsukuba),Nakamura Yukio(Fac. Applied Biol. Sci., Gifu University),Iagami Tadashi(Dept. Biochem., School Med., Vanderbilt University)
1 62-64   Apr 2004
Suzuki Fumiaki(Fac. Applied Biol. Sci.,Gifu University),Murakami Kazuo(Inst. Appli. Biochem. Univ. Tsukuba),Nakamura yukio(Fac. Applied Biol.Sci., Gifu University),Inagami Tadashi(Dept. Biochem., School Med., Vanderbilt University)
1 54-61   Apr 2004
Kawatsu Shoji(Dept. Total Health Management, Saitama Med. School ),Ishida Yuichi(Tokiwa Chemical Co.),Minagawa Shinya(1st Dept. Int. Med., Saitama Med. School ),Yazawa Masako(Dept. Int. Med., Saitama Med. School ),Tsuchida Atsuko(Dept. Int. Med., Saitama Med. School ),Ihara Chika(Dept. Int. Med., Saitama Med. School ),Hosaka Daiya(Dept. Int. Med., Saitama Med. School ),Imai Yasuo(Dept. Total HealthManagement, Saitama Med. School ),Suzuki Fumiaki(Fac. Applied Biol. Sci., Gifu Univeristy),Tanaka Hiroshi(Tokiwa Chemical Co.)
18 275-281   Sep 2004
Ichihara A.(Keio University School of Medicine),Uddin M. Nasir(Fac. Appl. Biol. Sci., Gifu University),Nabi AHM Nurun(United Gradiate School Agric., Gifu Univsrsity),Ishida Y.(Prevaqual Co.),Inagami T.(Dept. Biochem., Vanderbilt University),Saruta T.(Keio University School of Medicine),Hayashi M.(Keio University School of Medicine),KaneshiroY.(Keio University School of Medicine),Suzuki F.(Fac. Appl. Biol. Sci., Gifu University),Nakagawa T.(Fac. Appl. Biol. Sci., Gifu University),Tada Y.(Keio University School of Medicine),Koura Y.(Keio University School of Medicine),Nishiyama A.(Kagawa Medical School),Okada H.(Saitama Medical College)
114(8) 1128-1135   Oct 2004


A. H M Nurun Nabi, Kazal Boron Biswas, Yoshie Arai, Tsutomu Nakagawa, Tsutomu Nakagawa, Akio Ebihara, Akio Ebihara, Laila N. Islam, Fumiaki Suzuki, Fumiaki Suzuki
Frontiers in Bioscience   17 389-395
Before discovery of (pro)renin receptor, prorenin was regarded as a source of renin and probable diagnostic marker for diabetic nephropathy/Wilms' tumor. It is now considered that prorenin can perform renin activity by binding to (P)RR and binding...
Mariyo Sakoda, Atsuhiro Ichihara, Yuki Kaneshiro, Tomoko Takemitsu, Yuichi Nakazato, A. H M Nurun Nabi, Tsutomu Nakagawa, Fumiaki Suzuki, Fumiaki Suzuki, Tadashi Inagami, Hiroshi Itoh
Hypertension Research   30 1139-1146
Blockade of (pro)renin receptor has benefits in diabetic anglotensin II type-1a-receptor-deficient mice, suggesting the importance of (pro)renin receptor-mediated intracellular signals. To determine the mechanism whereby the human (pro)renin recep...
Afroza Sultana, A. H M Nurun Nabi, Uddin M. Nasir, Hiroe Maruyama, Kazu Michi Suzuki, Satoshi Mishima, Fumiaki Suzuki, Fumiaki Suzuki
International Journal of Molecular Medicine   21 677-681
Renin is the rate limiting enzyme in the renin-angiotensin (RA) system that regulates blood pressure and electrolyte balance. In this study, we investigated the renin inhibitory effect of a royal jelly (RJ)-derived peptide. A dipeptide YY was isol...
F. Suzuki, A. Takahashi, A. Hyodoh, S. Miyazaki, Y. Ishizuka, K. Murakami, Y. Nakamura
Biomedical Research   13 321-326
We developed a sandwich enzyme-linked immunosorbent assay (ELISA) system for human renin using 3,3',5,5'-tetramethylbenzidine as a chromogen. This ELISA could quantify the mature renin in the range from 2.5 to 250 pg (0.0675 to 6.75 fmol), and dis...
Afroza Sultana, A. H M Nurun Nabi, Kazal B. Biswas, Miki Takemoto, Fumiaki Suzuki, Fumiaki Suzuki
Frontiers in Bioscience   14 3286-3291   Jan 2009
Royal jelly (RJ) is known to possess several physiological and pharmacological properties. A dipeptide YY derived from RJ proteins is known to inhibit angiotensin converting enzyme (ACE) activity. Our previous study showed that the dipeptide YY in...

Books etc

Renin, Handbook of Proteolytic Enzymes(共著)
Academic Press   1998   

Conference Activities & Talks

Role of His(9, P2) and His(13, P3') in angiotensinogen for renin catalytic reaction.
Suzuki Fumiaki(Fac. Applied biol. Sci.)
Oct 2004   
Role of"handle"region of prosegment part of prorenin in
A.H.M. Nurun Nabi(Gifu Univ.),Inagami T.(Vanderbilt Univ.),Suzuki F.(Gifu Univ.),Uddin M. Nasir(Gifu Univ.),Nakagawa T.(Gifu Univ.),Sakata H.(Gifu Univ.),Iwata H.(Gifu Univ.),Iwata Hideyuki(Fac.Appl. Biol. Sci., Gifu University),Ichihara A.(Keio Univ.),Ishida U.(Prevaq. Co.),Hayashi Matsuhiko(Keio Univ., School Med.)
Jun 2005   
Role of handle region of prosegment part of prorenin in receptor-assiciated prorenin system.
Nabi A.H.M.Nurun(United Graduate school Agric. Sci., Gifu Univ.),Uddin M.Nasir(Fac. Appl. Biol. Sci., Gifu Univ.),Nakagawa Tsutomu(Fac. Appl. Biol. Sci., Gifu Univ.),Sakata Hirohito(Fac. Appl. Biol. Sci., Gifu Univ.),Iwata Hiroyuki(Fac. Appl. Biol. Sci., Gifu Univ.),Ichihara Atsuhiro(Keio Univ., School Med.),Ishida Yuichi(Prevaqual Co.),Inagami Tadashi(School Med., Vanderbilt University),Suzuki Fumiaki(Fac. Appl. Biol. Sci., Gifu Univ.)
Jun 2005   
A.H.M. Nurun Nabi(Gifu Univ.),Uddin M. Nasir(Gifu Univ.),Nakagawa T.(Gifu Univ.),Ichihara A.(Keio Univ.),Inagami T.(Vanderbilt Univ.),Suzuki F.(Gifu Univ.)
Oct 2006   
Inhibition of nonproteolytic activation of prorenin by a decoy peptide
Suzuki Fumiaki(Fac. Appl. Biol. Sci., Gifu Univ.)
Oct 2006   

Association Memberships



Molecular Biology on rat prorenin
Structural Biology on human prorenin
Structural Biology on sheep angiotensinogen

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Fumiaki SUZUKI
In 2004, I observed chick embryo, vitelline blood vessel network and related other vessel networks under dish culture, and recorded their developmental changes by camera and microscope for adequate periods to establish image analyses for them usin...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(一般研究(C))
Project Year: 1990 - 1991    Investigator(s): Fumiaki SUZUKI
Renin is an key enzyme in the renin-angiotensi-system which regulates the blood pressure. Recently, it has been observed that prorenin, the inactive form of mature renin, existed in the blood-stream. The prorenin concentration has been, moreover, ...
Investigation for catalytic mechanism of renin.
Molecular Biology of prorenin structure and its function.
Development of overepression syotem for recombinant proteins.


Antibody to the prorenin profragment, renin-active substance containing the same and prorenin assay reagent using the same.
European Patent No.0 873 999
Renin-active substance
US Patent No.6, 159, 723

Social Contribution

Bioscience, Biotechnology, and Biochemistry
[]  1 Nov 2005 - 31 Mar 2009