ISHIDA Hideharu

J-GLOBAL         Last updated: Dec 12, 2018 at 03:49
 
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Name
ISHIDA Hideharu
Affiliation
Gifu University
Section
Faculty of Applied Biological Sciences
Degree
(BLANK)

Research Interests

 
 

Research Areas

 

Academic & Professional Experience

 
Apr 2004
 - 
Today
Professor, Gifu University Faculty of Applied Biological Sciences
 
Oct 2016
 - 
Today
Director, Center for Highly Advanced Integration Nano and Life Sciences (G-CHAIN), Gifu University
 

Education

 
 
 - 
1988
Graduate School, Division of Natural Science, Hokkaido University
 
 
 - 
1982
Faculty of Agriculture, Gifu University
 

Published Papers

 
Imai T, Matsumura T, Mayer-Lambertz S, Wells CA, Ishikawa E, Butcher SK, Barnett TC, Walker MJ, Imamura A, Ishida H, Ikebe T, Miyamoto T, Ato M, Ohga S, Lepenies B, van Sorge NM, Yamasaki S
Proceedings of the National Academy of Sciences of the United States of America   115(45) E10662-E10671   Nov 2018   [Refereed]
Yoshida F, Yoshinaka H, Tanaka H, Hanashima S, Yamaguchi Y, Ishihara M, Saburomaru M, Kato Y, Saito R, Ando H, Kiso M, Imamura A, Ishida H
Chemistry (Weinheim an der Bergstrasse, Germany)      Oct 2018   [Refereed]
Uzawa J, Shimabukuro J, Suzuki T, Imamura A, Ishida H, Ando H, Yamaguchi Y
Magnetic resonance in chemistry : MRC   56(9) 836-846   Sep 2018   [Refereed]
Kijimoto-Ochiai S, Matsumoto-Mizuno T, Kamimura D, Murakami M, Kobayashi M, Matsuoka I, Ochiai H, Ishida H, Kiso M, Kamimura K, Koda T
Glycobiology   28(5) 306-317   May 2018   [Refereed]
Matsubara N, Imamura A, Yonemizu T, Akatsu C, Yang H, Ueki A, Watanabe N, Abdu-Allah H, Numoto N, Takematsu H, Kitazume S, Tedder TF, Marth JD, Ito N, Ando H, Ishida H, Kiso M, Tsubata T
Frontiers in immunology   9 820   Apr 2018   [Refereed]
Alborzian Deh Sheikh A, Akatsu C, Imamura A, Abdu-Allah HHM, Takematsu H, Ando H, Ishida H, Tsubata T
Biochemical and biophysical research communications   495(1) 854-859   Jan 2018   [Refereed]
Suzuki KGN, Ando H, Komura N, Konishi M, Imamura A, Ishida H, Kiso M, Fujiwara TK, Kusumi A
Methods in enzymology   598 267-282   2018   [Refereed]
Tanase M, Imamura A, Ando H, Kiso M, Ishida H
Bioscience, biotechnology, and biochemistry   81(12) 2268-2278   Dec 2017   [Refereed]
Ando Hiromune, Komura Naoko, Imamura Akihiro, Kiso Makoto, Ishida Hideharu
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   75(11) 1162-1170   Nov 2017   [Refereed]
Yagami Nahoko, Tamai Hideki, Udagawa Taro, Ueki Akiharu, Konishi Miku, Imamura Akihiro, Ishida Hideharu, Kiso Makoto, Ando Hiromune
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY   (32) 4778-4785   Sep 2017   [Refereed]
Chantarasrivong Chanikarn, Ueki Akiharu, Ohyama Ryutaro, Unga Johan, Nakamura Shinya, Nakanishi Isao, Higuchi Yuriko, Kawakami Shigeru, Ando Hiromune, Imamura Akihiro, Ishida Hideharu, Yamashita Fumiyoshi, Kiso Makoto, Hashida Mitsuru
MOLECULAR PHARMACEUTICS   14(5) 1528-1537   May 2017   [Refereed]
Shimabukuro Junpei, Makyio Hisayoshi, Suzuki Tatsuya, Nishikawa Yosuke, Kawasaki Masato, Imamura Akihiro, Ishida Hideharu, Ando Hiromune, Kato Ryuichi, Kiso Makoto
BIOORGANIC & MEDICINAL CHEMISTRY   25(3) 1132-1142   Feb 2017   [Refereed]
Syntheses of Bifunctional Photoaffinity Ganglioside Probes for Studying Raft-associated Interactions
Komura Naoko, Yamazaki Ayano, Imamura Akihiro, Ishida Hideharu, Kiso Makoto, Ando Hiromune
TRENDS IN CARBOHYDRATE RESEARCH   9(2) 1-26   2017   [Refereed]
Komura N, Suzuki KGN, Ando H, Konishi M, Imamura A, Ishida H, Kusumi A, Kiso M
Methods in enzymology   597 239-263   2017   [Refereed]
Imamura Akihiro, Matsuzawa Naomi, Sakai Shizuo, Udagawa Taro, Nakashima Shinya, Ando Hiromune, Ishida Hideharu, Kiso Makoto
JOURNAL OF ORGANIC CHEMISTRY   81(19) 9086-9104   Oct 2016   [Refereed]
Makyio Hisayoshi, Shimabukuro Junpei, Suzuki Tatsuya, Imamura Akihiro, Ishida Hideharu, Kiso Makoto, Ando Hiromune, Kato Ryuichi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   477(3) 477-482   Aug 2016   [Refereed]
Hyun Sang W., Liu Anguo, Liu Zhenguo, Cross Alan S., Verceles Avelino C., Magesh Sadagopan, Kommagalla Yadagiri, Kona Chandrababunaidu, Ando Hiromune, Luzina Irina G., Atamas Sergei P., Piepenbrink Kurt H., Sundberg Eric J., Guang Wei, Ishida Hideharu, Lillehoj Erik P., Goldblum Simeon E.
GLYCOBIOLOGY   26(8) 834-849   Aug 2016   [Refereed]
Goto Kenta, Sawa Maki, Tamai Hideki, Imamura Akihiro, Ando Hiromune, Ishida Hideharu, Kiso Makoto
CHEMISTRY-A EUROPEAN JOURNAL   22(24) 8323-8331   Jun 2016   [Refereed]
Naoko Komura, Kenichi G N Suzuki, Hiromune Ando, Miku Konishi, Machi Koikeda, Akihiro Imamura, Rahul Chadda, Takahiro K. Fujiwara, Hisae Tsuboi, Ren Sheng, Wonhwa Cho, Koichi Furukawa, Keiko Furukawa, Yoshio Yamauchi, Hideharu Ishida, Akihiro Kusumi, Makoto Kiso
Nature Chemical Biology   12(6) 402-U51   Jun 2016   [Refereed]
© 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. Gangliosides, glycosphingolipids containing one or more sialic acid(s) in the glyco-chain, are involved in various important physiological and patholo...
Sriwilaijaroen Nongluk, Magesh Sadagopan, Imamura Aldhiro, Ando Hiromune, Ishida Hideharu, Sakai Miho, Ishitsubo Erika, Hori Takanori, Moriya Setsuko, Ishikawa Takeshi, Kuwata Kazuo, Odagiri Takato, Tashiro Masato, Hiramatsu Hiroaki, Tsukamoto Kenji, Miyagi Taeko, Tokiwa Hiroaki, Kiso Makoto, Suzuki Yasuo
JOURNAL OF MEDICINAL CHEMISTRY   59(10) 4563-4577   May 2016   [Refereed]
Kobayashi Daisuke, Ueki Akiharu, Yamaji Tomoya, Nagao Kazuya, Imamura Akihiro, Ando Hiromune, Kiso Makoto, Ishida Hideharu
MOLECULES   21(5)    May 2016   [Refereed]
Maiko Tanase, Akihiro Imamura, Hiromune Ando, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Makoto Kiso
Organic Letters   18(6) 1454-1457   Mar 2016   [Refereed]
© 2016 American Chemical Society. A novel method for the synthesis of α-sialosides using a newly developed 5-ureido-modified sialyl donor is reported. The donor was found to be useful for α-selective sialidation with various glycosyl acceptors, fo...
Megumi Yamagishi, Ritsuko Hosoda-Yabe, Ritsuko Hosoda-Yabe, Hideki Tamai, Hideki Tamai, Miku Konishi, Miku Konishi, Akihiro Imamura, Hideharu Ishida, Tomio Yabe, Hiromune Ando, Hiromune Ando, Makoto Kiso, Makoto Kiso
Marine Drugs   13(12) 7250-7274   Dec 2015   [Refereed]
LLG-3 is a ganglioside isolated from the starfish Linchia laevigata. To clarify the structure-activity relationship of the glycan of LLG-3 toward rat pheochromocytoma PC12 cells in the presence of nerve growth factor, a series of mono- to tetrasac...
Goto, K., Suzuki, T., Tamai, H., Ogawa, J., Imamura, A., Ando, H., Ishida, H. and Kiso, M.
Asian J. Org. Chem.   4(10) 1160-1171   Oct 2015   [Refereed]
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The total synthesis of ganglioside PNG-2A from the starfish Protoreaster nodosus and its neuritogenic activity toward neuron-like cells is described. The unique galactose-enriched glycan moiety, i...
Hiroyuki Shinchi, Nobuhiro Yuki, Nobuhiro Yuki, Hideharu Ishida, Koichi Hirata, Masahiro Wakao, Yasuo Suda, Yasuo Suda
PLoS ONE   10(9)    Sep 2015   [Refereed]
© 2015 Shinchi et al. Sugar chain binding antibodies have gained substantial attention as biomarkers due to their crucial roles in various disorders. In this study, we developed simple and quick detection method of anti-sugar chain antibodies in s...
Tamai, H., Imamura, A., Ogawa, J., Ando, H., Ishida, H. and Kiso, M
Eur. J. Org. Chem.   2015(23) 5199-5211   Aug 2015   [Refereed]
Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The first total synthesis of neuritogenic ganglioside GAA-7 was achieved using the glucosyl ceramide (Glc-Cer) cassette approach. The stereocenter triad within the ceramide moiety of the...
Ueki, A., Un, K., Mino, Y., Yoshida, M., Kawakami, S., Ando, H., Ishida, H., Yamashita, F., Hashida, M. and Kiso, M.
Carbohydr. Res.   405 78-86   Mar 2015   [Refereed]
© 2014 Elsevier Ltd. All rights reserved. Novel sugar-conjugated cholesterols, β-Gal-, α-Man-, β-Man-, α-Fuc-, and β-Man-6P-S-β-Ala-Chol, were synthesized and incorporated into liposomes. In vitro experiments using the glyco-coated liposomes showe...
Abe, S., Tokura, Y., Pal, R., Komura, N., Imamura, A., Matsumoto, K., Ijiri, H., Sanghamitra, N.J.M., Tabe, H., Ando, H., Kiso, M., Mori, H., Kitagawa, S. and Ueno, T.
Chemistry Letters   44 29-31   2015   [Refereed]
Yabe, T., Hosoda-Yabe, R., Sakai, H., Kanamaru, Y. and Kiso, M.
Anal. Biochem.   472 1-6   2015   [Refereed]
Haruka Hirose, Hideki Tamai, Chao Gao, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Ten Feizi, Makoto Kiso
Organic&Bimolecular Chemistry   13 11105-11117   2015   [Refereed]
© 2015 The Royal Society of Chemistry. Total syntheses of two natural sulphoglycolipids, disulphated glycosphingolipid SB1a and the structurally related monosulphated SM1a, are described. They have common glycan sequences and ceramide moieties and...
Hirose Haruka, Tamai Hideki, Gao Chao, Imamura Akihiro, Ando Hiromune, Ishida Hideharu, Feizi Ten, Kiso Makoto
ORGANIC & BIOMOLECULAR CHEMISTRY   13(45) 11105-11117   2015   [Refereed]
Sweet Role of Platelet Endothelial Cell Adhesion Molecule (PECAM) in Understanding Angiogenesis
Kitazume Shinobu, Imamaki Rie, Kurimoto Ayako, Ogawa Kazuko, Kato Masaki, Yamaguchi Yoshiki, Tanaka Katsunori, Ishida Hideharu, Ando Hiromune, Kiso Makoto, Hashii Noritaka, Kawasaki Nana, Taniguchi Naoyuki
GLYCOBIOLOGY   24(11) 1218   Nov 2014   [Refereed]
Role of CD22/Siglec-2 and its ligand in B lymphocyte activation
Matsubara Naoko, Takematsu Hiromu, Ishida Hideharu, Tsubata Takeshi
GLYCOBIOLOGY   24(11) 1090   Nov 2014   [Refereed]
Kitazume, S., Imamaki, R., Kurimoto, A., Ogawa, K., Kato, M., Yamaguchi, Y., Tanaka, K., Ishida, H., Ando, H., Kiso, M., Hashii, N., Kawasaki, N. and Taniguchi, N.
J. Biol. Chem.   289(40) 27604-27613   Oct 2014   [Refereed]
© 2014 by The American Society for Biochemistry and Molecular Biology Inc. The luminal sides of vascular endothelial cells are heavily covered with a so-called glycocalyx, but the precise role of the endothelial glycocalyx remains unclear. Our pre...
Suzuki, T., Makyio, H., Ando, H., Komura, N., Menjo, M., Yamada, Y., Imamura, A., Ishida, H., Wakatsuki, S., Kato, R. and Kiso, M.
Bioorg. Med. Chem   22(7) 2090-2101   Apr 2014   [Refereed]
Seleno-lactoses have been successfully synthesized as candidates for mimicking carbohydrate ligands for human galectin-9 N-terminal carbohydrate recognition domain (NCRD). Selenium was introduced into the mono- or di-saccharides using p-methylsele...
Suzuki, T., Komura, N., Imamura, A., Ando, H., Ishida, H. and Kiso, M.
Tetrahedron Lett.   55(11) 1920-1923   Mar 2014   [Refereed]
A facile reaction for constructing selenoglycosides has been developed based on the transacetalization reaction between a selenoacetal and a glycosyl imidate. Glycosyl imidates were activated with TMSOTf to produce oxocarbenium ion, which reacted ...
Menjo, M., Tamai, H., Ando, H., Ishida, H., Koketsu, M. and Kiso, M.
HETEROCYCLES   88(2) 1587-1594   Jan 2014   [Refereed]
Nobuhiro Yuki, Nobuhiro Yuki, Chiaki Yanaka, Makoto Sudo, Miyuki Funakoshi, Hideharu Ishida, Masahiro Mori, Fumio Kanda, Koichi Hirata
Journal of Neuroimmunology   272(1-2) 62-66   Jan 2014   [Refereed]
A patient, who developed an amyotrophic lateral sclerosis-like disorder subsequent to ganglioside treatment, had IgM antibodies to GM2 as well as to minor gangliosides X1 and X2 containing GM2 epitope. These gangliosides as well as GM1 were tested...
Hara, A., Imamura, A., Ando, H., Ishida, H. and Kiso, M
Molecules   19(1) 414-437   Dec 2013   [Refereed]
A new chemical approach to synthesizing human ABO histo-blood type 2 antigenic determinants was developed. N-Phthaloyl-protected lactosaminyl thioglycoside derived from lactulose via the Heyns rearrangement was employed to obtain a type 2 core dis...
Rare 6-deoxy-d-altrose from the folk medicinal mushroom Lactarius akahatsu
Tako, M., Shimabukuro, J., Jiang, W.,Yamada, M., Ishida, H. and Kiso, M.
Biochemical Compounds      Oct 2013   [Refereed]
Konishi, M., Imamura, A., Fujikawa, K., Ando, H., Ishida, H. and Kiso, M.
Molecules   18(12) 15153-15181   Oct 2013   [Refereed]
The development of a novel cyclic glucosyl ceramide cassette acceptor for efficient glycolipid syntheses was investigated. p-Methoxybenzyl (PMB) groups were selected as protecting groups at C2 and C3 of the glucose residue with the aim of improvin...
Kasai T, Nakane D, Ishida H, Ando H, Kiso M, Miyata M
Journal of bacteriology   195(3) 429-435   Feb 2013   [Refereed]
Nohara T, Imamura A, Yamaguchi M, Hidari KI, Suzuki T, Komori T, Ando H, Ishida H, Kiso M
Molecules (Basel, Switzerland)   17(8) 9590-9620   Aug 2012   [Refereed]
Nakashima S, Ando H, Saito R, Tamai H, Ishida H, Kiso M
Chemistry, an Asian journal   7(5) 1041-1051   May 2012   [Refereed]
Tako M, Dobashi Y, Tamaki Y, Konishi T, Yamada M, Ishida H, Kiso M
Carbohydrate research   350 25-30   Mar 2012   [Refereed]
Shimizu Hiroyo, Iwayama Yuki, Imamura Akihiro, Ando Hiromune, Ishida Hideharu, Kiso Makoto
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   75(10) 2079-2082   Oct 2011   [Refereed]
Sadagopan, M., Ando,H., Tsubata, T., Ishida, H. and Kiso, M.
Current Medicinal Chemistry   18 3537-3550   Sep 2011   [Refereed]
Sialic acids are one of the important constituents of glycoconjugates in the deuterostome lineage of animals and microorganisms. Siglecs (Sialic acid-binding immunoglobulin like lectins) are a family of cell-surface receptor proteins that recogniz...
Iwayama Y, Ando H, Tanaka HN, Ishida H, Kiso M
Chemical communications (Cambridge, England)   47(34) 9726-9728   Sep 2011   [Refereed]
Abdu-Allah, H. H. M., Watanabe, K., Daikoku, S., Kanie, O., Tsubata, T., Ando, H., Ishida, H. and Kiso, M.
Synthesis   (18) 2968-2974   Aug 2011   [Refereed]
We describe the design and synthesis of a trivalent CD22 ligand conjugated with a trivalent nitrophenol (ligand for decameric anti-nitrophenol immunoglobulin M). To generate such a bifunctional ligand, we designed and prepared two synthetic buildi...
Fujikawa, K., Nakashima, S., Konishi, M., Fuse, T., Komura, N., Ando, T., Ando, H., Yuki, N., Ishida, H. and Kiso, M.
Chem. Eur. J.   17(20) 5461-5651   Jul 2011   [Refereed]
Abdu-Allah HH, Watanabe K, Completo GC, Sadagopan M, Hayashizaki K, Takaku C, Tamanaka T, Takematsu H, Kozutsumi Y, Paulson JC, Tsubata T, Ando H, Ishida H, Kiso M
Bioorganic & medicinal chemistry   19(6) 1966-1971   Mar 2011   [Refereed]
Nao Ogasawara, Nao Ogasawara, Yohko U. Katagiri, Yohko U. Katagiri, Nobutaka Kiyokawa, Nobutaka Kiyokawa, Tomonori Kaneko, Tomonori Kaneko, Ban Sato, Ban Sato, Hideki Nakajima, Yoshitaka Miyagawa, Yasunori Kushi, Hideharu Ishida, Makoto Kiso, Hajime Okita, Hajime Okita, Toshinori Sato, Junichiro Fujimoto, Junichiro Fujimoto
Journal of Biochemistry   149(3) 321-330   Mar 2011   [Refereed]
Using dodecyl N-acetylglucosaminide (GlcNAc-C12) as a saccharide primer, we investigated the biosynthetic changes of neolacto-series glycosphingolipids (GSLs) in mouse embryonal carcinoma F9 cells during differentiation induced by retinoic acid pl...
Tamai H, Ando H, Tanaka HN, Hosoda-Yabe R, Yabe T, Ishida H, Kiso M
Angewandte Chemie (International ed. in English)   50(10) 2330-2333   Mar 2011   [Refereed]
Nakashima, S., Ando, H., Imamura, A., Yuki, N., Ishida, H. and Kiso, M.
Chem. Eur. J.   17(2) 588-597   Feb 2011   [Refereed]
The hybrid ganglioside X1, which was identified in the bovine brain, was synthesized for the first time. Ganglioside X1 is believed to be involved in the development of amyotrophic lateral sclerosis-like disorders in patients with neurological dis...
Yamada, M., Yoshida, F., Ando, H., Ishida, H., Kiso, M. and Tako, M.
HETEROCYCLES   82(2) 1699-1704   Jan 2011   [Refereed]
Here, we describe the synthesis of 6-deoxy-D-altrose and its subsequent use as an authentic sample to verify the structure of a monosaccharide newly isolated from the fruiting body of an edible mushroom. D-Rhamnopyranoside, converted from D-mannop...
Evaluation of a set of C9 N-acylNeu5Ac2en mimetics as viral sialidase selective inhibitors
Sadagopan, M., Sriwilaijaroen, S., Moriya, S., Ando, H., Miyagi, T., Suzuki, Y., Ishida, H. and Kiso, M.
International Journal of Medicinal Chemistry   1-7   Jan 2011   [Refereed]
Shimizu H, Iwayama Y, Imamura A, Ando H, Ishida H, Kiso M
Bioscience, biotechnology, and biochemistry   75 2079-2082   2011   [Refereed]
Sadagopan, M., Sriwilaijaroen, N., Vats, S., Ando, H., Miyagi, T, T., Suzuki, Ishida, H. and Kiso, M.: Investigation of 2-fluoro benzoic acid derivatives as influenza A viral sialidase selective inhibitors
Anti-Infective Agents in Medicinal Chemistry   9(4) 198-204   Dec 2010   [Refereed]
Neuraminidase (NA), a glycoside hydrolase enzyme, plays pivotal roles in controlling biological functions not only of influenza viruses but also of humans. Zanamivir and oseltamivir designed to target influenza neuraminidase have become extensivel...
Inhibitory Potency of Tamiflu and DANA and their Modified Derivatives on Lipopolysaccharide-Induced Neu1 Sialidase Activity in Live BMA Macrophage Cells
Ademidun David, Guo Merry, Abdulkhalek Samar, Gilmour Alanna, Jayanth Preethi, Magesh Sadagopan, Ishida Hideharu, Ando Hiromune, Kiso Makoto, Wernerova Martina, Werner Lukas, Machara Ales, Hudlicky Tomas, Szewczuk Myron
GLYCOBIOLOGY   20(11) 1478   Nov 2010   [Refereed]
Discovery of 6-deoxy-D-altrose in nature
Tako Masakuni, Yogi Takuya, Izumori Ken, Ishida Hideharu, Kiso Makoto
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   240    Aug 2010   [Refereed]
Yamanaka, T., Tsujimura, K., Kondo, T., Matsumura, T., Ishida, H., Kiso, M., Hidari, K. I. P. J. and Suzuki, T.
Influenza and Other Respiratory Viruses   4(6) 345-351   Jul 2010   [Refereed]
Please cite this paper as: Yamanaka et al. (2010) Infectivity and pathogenicity of canine H3N8 influenza A virus in horses. Influenza and Other Respiratory Viruses 4(6), 345-351. Background Equine H3N8 influenza A viruses (EIVs) cause respiratory ...
Fujikawa, K., Nohara, T., Imamura, A., Ando, H., Ishida, H. and Kiso, M.
Tetrahedron Lett.,   51(7) 1126-1130   Feb 2010   [Refereed]
A cyclic glucosyl ceramide (GlcCer) acceptor has been developed as a versatile building block for the synthesis of complex ganglioside. A macrocyclic GlcCer acceptor, which was the product of intramolecular glycosylation between glucose and cerami...
Sadagopan, Magesh, Moriya, S., Suzuki, T., Miyagi, T., Ishida, H. and Kiso, M.
MEDICINAL CHEMISTRY RESEARCH   19(19) 1273-1286   Jan 2010   [Refereed]
Recent studies have determined the molecular mechanisms underlying the pathological alterations of sialic acid or its conjugates in various human disease states, and the sialic acid modifying enzyme sialidase has been adopted as an attractive ther...
Hiromune Ando, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Makoto Kiso
Methods in Enzymology   478 521-540   2010   [Refereed]
It is well known that gangliosides, sialic acid-containing glycosphingolipids, play important roles in diverse biological processes associated with cell development, immune response, cancer metastasis, infection, and signal transduction. Synthetic...
Abdu-Allah, H., Watanabe, K., Hayashizaki, K., Takaku, C., Tamanaka, T., Takematsu, H., Kozutsumi, Y., Tsubata,T., Ishida,H. and Kiso, M.
Bioorganic&Medicinal Chemistry Letters   19 5573-5575   Sep 2009   [Refereed]
Our previous study revealed that compound 1 (9-(4′-hydroxy-4-biphenyl)acetamido-9-deoxy-Neu5Gcα2-6GalOMP) has the most promising affinity for mCD22. Replacing the subterminal galactose residue of 1 with benzyl or biphenylmethyl as aglycone led to ...
Takahashi, T., Hashimoto, A., Maruyama, M., Ishida, H., Kiso, M., Kawaoka, Y., Suzuki, Y. and Suzuki, T.
FEBS Lett,   583(19) 3171-3174   Aug 2009   [Refereed]
To identify a determinant of human H3 hemagglutinin (HA) amino acid residues linked to the recognition of molecular species of sialic acid, we generated six mutant viruses possessing either the wild-type HA gene from A/Memphis/1/71 (H3N2) or a gen...
Tatsuya Komori, Akihiro Imamura, Akihiro Imamura, Hiromune Ando, Hiromune Ando, Hideharu Ishida, Makoto Kiso, Makoto Kiso
Carbohydrate Research   344(12) 1453-1463   Aug 2009   [Refereed]
A first systematic synthesis of the glycan parts of the a-series gangliosides (GT1a, GD1a, and GM1) utilizing the newly developed N-Troc-protected GM3 and galactosaminyl building blocks is described. The key processes, including the assembly of th...
Tanaka, H., Ando, H., Ishida, H., Kiso, M., Ishihara, H. and Koketsu, M.:
Tetrahedron Lett.   50(31) 4478-4481   Jul 2009   [Refereed]
An attempt to synthesize α(2→8)-linked oligosialic acid utilizing a 1,5-lactamized sialyl acceptor is described. 1,5-Lactamization was experimentally proven to proceed only for α-sialoside, which was integrated into the synthetic cycle of oligosia...
Abdu-Allah, Hajjaj Hassan Mohamed, Watanabe, K., Hayashizaki, K., Iwayama, Y., Takematsu, H., Kozutsumi, Y., Tsubata, T., Ishida, H. and Kiso, M.:
Tetrahedron Lett   50(31) 4488-4491   Jun 2009   [Refereed]
Biotin conjugate of the most potent ligand for mouse CD22 was designed and synthesized. The key synthetic step involved the dual capability of Hanessian reaction for debenzylation and simultaneous conversion of the anomeric p-methoxyphenyl group i...
Iwayama, Y., Ando, H., Ishida, H. and Kiso, M.
Chem. Euro. J.   15(18) 4637-4648   May 2009   [Refereed]
A first synthesis of the neuri-tegenic ganglioside HLG-2, which was identified in extracts of the sea cucumber Holothuria leucospilota, is described. The characteristic sequence of the trisaccharide part, α-N-glycolylsial-yl-(2,4)-& alpha;-N-acety...
Magesh, S., Savita, V., Moriya, S., Suzuki, T., Miyagi, T., Ishida, H. and Kiso, M.
Bioorganic&Medicinal Chemistry   17(13) 4595-4603   May 2009   [Refereed]
Recent advances in the sialidase biology have clarified the role of human sialidases (NEU 1 to NEU4) in the development of various disease states such as cancer, diabetes and arteriosclerosis. Isoform selective human sialidase inhibitors could be ...
Imamura, A., Ando, H., Ishida, H. and Kiso, M.
J. Org. Chem.   74(8) 3009-3023   May 2009   [Refereed]
The convergent total synthesis of ganglioside GQ1b based on the "cassette approach" between the nonreducing end GQ1b-core heptasaccharide and glucosylceramide building blocks was accomplished in high overall yield. The use of a sialylα(2→8)sialylα...
Ishibashi, Y.,Nagamatsu, Y., Meyer, S., Imamura, A., Ishida, H., Kiso, M., Okino, N., Geyer, R. and Ito, M.
Glycobiology   19(7) 797-807   Apr 2009   [Refereed]
Although 6-gala series glycosphingolipids possessing R-Gal (α/ β) 1-6Galβ1-1′Cer have been found in some mollusks, pathogenic parasites, and fungi, their physiological functions and metabolic pathway are not fully understood. We described a novel ...
Kawasaki, N., Lin, C.-W., Inoue, R., Khoo, K.-H., Kawasaki, N., Ma, B.Y., Oka, S., Ishiguro, M., Sawada, T., Ishida, H., Hashimoto, T. and Kawasaki, T.
Glycobiology   19(4) 437-450   Apr 2009   [Refereed]
The serum mannan-binding protein (MBP) is a host defense C-type lectin specific for mannose, N-acetylglucosamine, and fucose residues, and exhibits growth inhibitory activity toward human colorectal carcinoma cells. The MBP-ligand oligosaccharides...
Sato, T., Imamura, A., Ando, H., Ishida, H. and Kiso, M.
Glycoconjugate Journal   26(1) 83-98   Feb 2009   [Refereed]
Seven analogues of p-nitrophenyl T-antigen [Galβ(1→3) GalNAcα(1→O)PNP] have been synthesized as potential substrates for elucidation of the substrate specificity of endo-α-N- acetylgalactosaminidase. These compounds, which are commercially unavail...
Yuki Shioiri, Ayako Kurimoto, Takuro Ako, Shusaku Daikoku, Atsuko Ohtake, Hideharu Ishida, Makoto Kiso, Katsuhiko Suzuki, Osamu Kanie, Osamu Kanie
Analytical Chemistry   81(1) 139-145   Jan 2009   [Refereed]
Gangliosides, a family of glycosphingolipids (GSLs) that comprise sialic acid residue(s), are an important class of molecules that exist on the outer surface of the plasma membrane. To assess the functions of a particular series of gangliosides th...
Imamura Alkihiro, Ando Hiromune, Ishida Hideharu, Kiso Makoto
HETEROCYCLES   76(2) 883-908   Nov 2008   [Refereed]
Ashida, H., Maki, R., Ozawa, H., Yani, Y., Kiyohara, M., Fujita, M., Imamura, A., Ishida, H., Kiso, M. and Yamamoto, K.
Glycobiology   18(9) 727-734   Oct 2008   [Refereed]
Endo-α-N-acetylgalactosaminidase (endo-α-GalNAc-ase) catalyzes the hydrolysis of the O-glycosidic bond between α-GalNAc at the reducing end of mucin-type sugar chains and serine-threonine of proteins to release oligosaccharides. Previously, we ide...
HajjajHassan Mohamed, Abdu-Allah., Tamanaka, T., Yu, J., Lu, Z., Magesh, S., Adachi, T., Tsubata, T., Kelm, S., Ishida, H. and Kiso, M.:
Journal of Medicinal Chemistry   51(21) 6665-6681   Sep 2008   [Refereed]
Sialosides incorporating substituted amides or amines at 9-position of sialic acid moiety have been synthesized and evaluated as CD22 inhibitors. Several derivatives exhibited inhibitory potency in sub- to low micromolar range (e. g., 80, 9d, 9g, ...
Fujikawa, K., Imamura, A., Ishida, H. and Kiso, M.
Carbohydr. Res   343(16) 2729-2734   Sep 2008   [Refereed]
A novel analogue of ganglioside GM3, in which sphingosine was replaced with a phytosphingosine moiety, was synthesized by intramolecular glycosylation as a key step. Glucose, a reducing terminal of the saccharide, and phytoceramide were first teth...
Yamaguchi, M., Ishida, H. and Kiso, M.
HETEROCYCLES   77(1) 333-349   Aug 2008   [Refereed]
Synthesis of three kinds of 6-O-sulfated sLex glyco probes with their relevance to ligand processing pathway of L-selectin has been described. The glycosylation of the suitably protected hexasaccharide acceptor 6 with the sialyl-α-(2→3)-D-galactop...
Sawada, T., Hashimoto, T., Tokiwa, H., Suzuki, T., Nakano, H., Ishida, H., Kiso, M. and Suzuki, Y.
Glycoconjugate J.   25(9) 805-815   Jun 2008   [Refereed]
If we predict the host range of new or mutant influenza virus in advance, we are able to measure against pandemic human influenza immediately after the new virus emerges somewhere. Influenza viral hemagglutinin(HA)-sialoside receptor interaction i...
Yamaguchi, M., Ishida, H. and Kiso, M.
Carbohydr. Res.   343(10-11) 1849-1857   Jun 2008   [Refereed]
The total synthesis of 6-O-sulfo-sialylparagloboside is described. A suitably protected β-d-GlcpNAc-(1→3)-β-d-Galp-(1→4)-d-GlcpOSE derivative was glycosylated with an α-d-Neup5Ac-(2→3)-d-Galp derived imidate to give the corresponding protected α-d...
Imamura, A., Ando, H., Ishida, H. and Kiso, M.
HETEROCYCLES   76(76) 883-908   May 2008   [Refereed]
This review outlines the chemistry of 1,2-cis glycosylations and discusses the state-of-the-art methods, highlighting the DTBS(di-tert-butylsilylene)-directed α-galactosylation that was recently developed by our group. The key feature of our uniqu...
Imamura, A., Ando, H., Ishida, H. and Kiso, M.
Curr. Org. Chem.   12 675-689   Apr 2008   [Refereed]
Komori, T., Ando, T., Imamura, A., Li, Y.-T., Ishida, H. and Kiso, M.
Glycoconjugate J   25(7) 647-661   Mar 2008   [Refereed]
To elucidate the mechanism underlying the hydrolysis of the GalNAcβ1→4Gal linkage in ganglioside GM2 [GalNAcβ1→ 4(NeuAcα2→3)Galβ1→4Glcβ1→1′ Cer] by β-hexosaminidase A (Hex A) with GM2 activator protein, we designed and synthesized two kinds of GM2...
Imamura, A., Yoshikawa, T., Komori, T., Ando, M., Ando, H., Wakao, M., Suda, Y., Ishida, H. and Kiso, M.
Glycoconjugate J   25(3) 269-278   Jan 2008   [Refereed]
A series of ganglioside GM1-, GM2-, and GM3-type probes, in which the ceramide portion is replaced with a glucose residue, were systematically synthesized based on a convergent synthetic method. © 2008 Springer Science+Business Media, LLC.
Yoshikawa, T., Kato, Y., Yuki, N., Yabe, T., Ishida, H. and Kiso, M.
Glycoconjugate J   25(6) 545-553   Jan 2008   [Refereed]
GM1 epitope tetrasaccharide was synthesized by a condensation of sialyl-α(2-3)-gal acceptor and gal-β(1-3)-GalN donor in a highly efficient manner. After introduction of mercaptohexanol to the tetrasaccharide, it was coupled to maleimide-activated...
Magesh, S., Moriya, S., Suzuki, T., Miyagi, T., Ishida, H. and Kiso, M.:
Bioorg. Med. Chem. Lett   18(2) 532-537   Jan 2008   [Refereed]
We here report the design and synthesis of selective human lysosomal sialidase (NEU1) inhibitors. A series of amide-linked C9 modified DANA (2-deoxy-2,3-dehydro-N-acetylneuraminic acid) analogues were synthesized and their inhibitory activities ag...
Li, Y.-T., Li, S.-C., Kiso, M., Ishida, H., Mauri, L., Raimondi, L., Bernardi, A. and Sonnino, S.
Biochimica et Biophysica Acta   1780(3) 353-361   Oct 2007   [Refereed]
The effect of inter-molecular carbohydrate-to-carbohydrate interaction on basic cell biological processes has been well documented and appreciated. In contrast, very little is known about the intra-molecular carbohydrate-to-carbohydrate interactio...
J. Yu, T. Sawada, T. Adachi, X. Gao, H. Takematsu, Y. Kozutsumi, H . Ishida, M. Kiso and T. Tsubata
Biochem. Biophys. Res. commun.   360(4) 759-764   Jul 2007   [Refereed]
CD22/Siglec-2 is a B cell membrane-bound lectin that recognizes glycan ligands containing α2,6-linked sialic acid, and negatively regulates signaling through the B cell antigen receptor (BCR). Previous studies demonstrated that synthetic sialoside...
Yoon, S.-J., Ikeda, S., Sadilek, M., Hakomori, S., Ishida, H. and KIso, M
Glycobiology   17(9) 1007-1014   Jul 2007   [Refereed]
Aminoceramide mimetic was synthesized and conjugated to N-linked oligosaccharides having multivalent GlcNAc by reductive amination. Ceramide mimetic conjugates with "complex-type" glycan having five or six GlcNAc termini (termed Os Fr. B-Cer) were...
T. Sawada, T. Hasimoto, H. Nakano, T. Suzuki, Y. Suzuki, Y. Kawaoka, H. Ishidaand M. Kiso
Biochem. Biophys. Res. commun.   355(1) 6-9   Feb 2007   [Refereed]
Do the complexity and the bulkiness of a protein affect the affinity between protein and ligand? We attempted to investigate this problem by using ab initio fragment molecular orbital (FMO) method to calculate the binding energy between human infl...
Ishibashi, Y., Nakasone, T., Kiyohara, M., Horibata, Y., Sakaguchi, K., Hijikata, A., Ichinose, S., Omori, A., Yasui, Y., Imamura, A., Ishida, H., Kiso, M., Okino, N. and Ito, M
J. Biol. Chem   282(15) 11386-11396   Jan 2007   [Refereed]
Enzymes capable of hydrolyzing the β-glycosidic linkage between oligosaccharides and ceramides in various glycosphingolipids has been found in microorganisms and invertebrates and designated endoglycoceramidase (EC 3.2.1.123) or ceramide glycanase...
Takaku, H., Ishida, H.-K., Fujita, M., Inazu, T., Ishida, H. and Kiso, M.
Synlett   5(5) 818-820   Jan 2007   [Refereed]
A first chemical synthesis of GlcNAcβ(1→4)GlcUA-UDP is described here. This compound can be an essential tool to elucidate the catalytic mechanism of hyaluronic acid synthases (HAS) and this synthetic strategy contributes to the synthesis of vario...
Hironao Takaku, Hironao Takaku, Junhei Sato, Hide Ki Ishida, Toshiyuki Inazu, Hideharu Ishida, Hideharu Ishida, Makoto Kiso, Makoto Kiso
Glycoconjugate Journal   23(7-8) 565-573   Nov 2006   [Refereed]
A chemical synthesis of uridine 5'-diphospho-N-acetyllactosamine (Galβ(1→4)GlcNAc-UDP; UDP-LacNAc) and Galβ(1→3)GlcNAc-UDP is described. Coupling of the disaccharide imidate derivatives with dibenzylphosphate gave the corresponding 1-phosphates, w...
Characterization of a human H5N1 influenza A virus isolated in 2003
Takaku Hironao(Gifu University),Sato Junhei(Tokai University),Ishida Hide-ki(The Noguchi Institute),Inazu Toshiyuki(Tokai Universitry),Ishida Hideharu(Gifu University),Kiso Makoto(Gifu University)
Glycoconjugate J.   23 565-573   Apr 2006   [Refereed]
KImura Akiyoshi(Gifu University),Imamura Akihiro(Gifu University),Ando Hiromune(Gifu University),Ishida Hideharu(Gifu University),Kiso Makoto(Gifu University)
Synlett   15(15) 2379-2382   Apr 2006   [Refereed]
A novel synthetic route to α-galactosyl ceramides and isoglobotrihexosylceramide (iGb3), which can activate NKT cells, was developed by exploiting a di-tert-butylsilylene-directed α-selective galactosylation procedure. © Georg Thieme Verlag Stuttg...

Misc

 
狩野裕考, 新田昂大, 郷慎司, 藤居真優, 樺山一哉, 下山敦史, 深瀬浩一, 安藤弘宗, 石田秀治, 鈴木明身, 井ノ口仁一
日本糖質学会年会要旨集   37th 178   Aug 2018
八神なほ子, 今村彰宏, 石田秀治, 石田秀治, 安藤弘宗
日本糖質学会年会要旨集   37th 137   Aug 2018
浅野早知, 河村奈緒子, 今村彰宏, 鈴木健一, 石田秀治, 石田秀治, 安藤弘宗
日本糖質学会年会要旨集   37th 142   Aug 2018
浅野拓也, 今村彰宏, 石田秀治, 石田秀治
日本農芸化学会大会講演要旨集(Web)   2018 ROMBUNNO.2A20a01 (WEB ONLY)   Mar 2018
濱屋湧, 安藤弘宗, 石田秀治, 石田秀治, 田中秀則
日本農芸化学会大会講演要旨集(Web)   2018 ROMBUNNO.2A20p07 (WEB ONLY)   Mar 2018
河村奈緒子, 加藤慶一, 今村彰宏, 石田秀治, 石田秀治, 安藤弘宗
日本農芸化学会大会講演要旨集(Web)   2018 ROMBUNNO.2A20p11 (WEB ONLY)   Mar 2018
田中友理, 前田雄介, 今村彰宏, 今村彰宏, 石田秀治, 石田秀治, 上野義仁, 上野義仁, 安藤弘宗
日本農芸化学会大会講演要旨集(Web)   2018 ROMBUNNO.2A20p09 (WEB ONLY)   Mar 2018
栗田一生, 八神なほ子, 今井崇史, 山崎晶, 今村彰宏, 安藤弘宗, 安藤弘宗, 石田秀治, 石田秀治
日本農芸化学会大会講演要旨集(Web)   2018 ROMBUNNO.2A20p08 (WEB ONLY)   Mar 2018
中田えりな, 今村彰宏, 石田秀治, 石田秀治, 安藤弘宗
日本農芸化学会大会講演要旨集(Web)   2018 ROMBUNNO.2A20a02 (WEB ONLY)   Mar 2018
浅野早知, 河村奈緒子, 今村彰宏, 鈴木健一, 石田秀治, 石田秀治, 安藤弘宗
日本農芸化学会大会講演要旨集(Web)   2018 ROMBUNNO.2A20p12 (WEB ONLY)   Mar 2018
Trends in Glycosci. Glycotechnol.(TIGG)   13 57-64   2001
Hideharu Ishida, Makoto Kiso
J. Synth. Org. Chem., Jpn.   58(11) 1108-1113   2000
Hideharu ISHIDA
Nippon Nōgeikagaku Kaishi   72(11) 1325-1332   1998
Bioscience, Bitotechnology and Biochemistry   61(9) 1615-1616   1997
Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Makoto Kiso
Current Organic Chemistry   12 675-689
This review outlines the chemistry of 1,2-cis glycosylations and discusses the state-of-the-art methods highlighting the DTBS-directed α-galactosylation recently developed by our group. © 2008 Bentham Science Publishers Ltd.
Makoto Kiso, Makoto Kiso, Hideharu Ishida, Hiromune Ando, Hiromune Ando, Akihiro Imamura
Glycoscience: Biology and Medicine   331-338
© Springer Japan 2015. Various methodologies for the chemical synthesis of gangliosides have been explored so far and a lot of natural gangliosides including their structural analogues have been synthesized during the past three decades. Key techn...
Hideharu Ishida
Carbohydrates in Chemistry and Biology   1-4 305-317
Hideharu Ishida
Trends in Glycoscience and Glycotechnology   15 255

Books etc

 
Essential of Glycobiology second edition
Akimoto, Y., Ando, H., Ishida, H., Kiso, M., et al.,
丸善   Dec 2010   
コールドスプリングハーバー 糖鎖生物学 第2版
Renewed synthetic approach to gangliosides exploiting versatile and powerful synthetic units, in Methods In Enzymology, Glycomics
Ando, H., Ishida, H. and Kiso, M.
Elsevier   Dec 2010   
Renewed synthetic approach to gangliosides exploiting versatile and powerful synthetic units, in Methods In Enzymology, Glycomics
How does the FMO method help in studying viruses and their binding to receptors, In: The Fragment molecular orbital method: Practical applications to large molecular systems
Sawada, T., Hashimoto, T., Tokiwa, H., Suzuki, T., Nakano, H., Ishida, H., Kiso, M. and Suzuki, Y. (Part:Joint Work, 193-215)
CRC PRESS   Jun 2009   
How does the FMO method help in studying viruses and their binding to receptors, In: The Fragment molecular orbital method: Practical applications to large molecular systems
Synthesis of glycolipids. In Comprehensive Glycoscience
ISHIDA Hideharu (Part:Joint Work)
Elsevier Limited   2007   
Carbohydrate
Academic Press   2003   

Conference Activities & Talks

 
A structure guided approach for isoform selective human sialidase inhibitors
May 2009   
A synthesis of ganglioside GQ1b based on a novel synthetic strategy of B-series gangliosides
Imamura akihiro(Gifu University),Ando Hiromune(Gifu University),Ishida Hideharu(Gifu University),Kiso Makoto(Gifu University)
Jul 2004   
Synthesis and biological evaluation of the mimics of cis ligand for CD22
Yuki Suganuma, Naoko Matsubara, Yuki Iwayama, Akiharu Ueki, Akihiro Imamura, Hiromune Ando, Takeshi Tsubata, Hideharu Ishida and Makoto Kiso
The 4th Asian Communication for Glycobiology and Glycotechnology (ACGG)   Oct 2012   
CD22特異的阻害剤としての新規シアロシドの設計と合成
Abdu-Allah Hajjaj Hassan Mohamed(GIfu Univ)
May 2007   
Chemical synthesis of cell surface glycans in pluripotent stem cells for cultivating their biological potential
Pal, R., Komura, N., Imamura, A., Ishida, H., Ando, H. and Kiso, M.
iCeMS International Symposium"Hierarchical Dynamics in Soft Materials and Biological Matter"   Sep 2015   iCeMS

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2009 - 2011    Investigator(s): Hideharu ISHIDA
Functions of siglec-2 expressed on B cell and mannan-binding protein(MBP) concerned with innate immunity were studied by employing their synthetic ligands as well as inhibitors. A novel, potent inhibitor of siglec-2 was developed based on the stru...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2005    Investigator(s): Hideharu ISHIDA
Glycosphingolipids are characteristic membrane components of eukaryotic cells where they are distinguished from other glycosphingolipids by containing one or more sialic acid residues, and have been recognized play important roles in many biologic...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 1998 - 1999    Investigator(s): Hideharu ISHIDA
Certain species of anti-gangliosides are associated with specific clinical features in various neurologic diseases such as Guillain-Barre syndrome (GBS). In this project, two kinds of glyco-conjugates were synthesized to clarify the mechanism to c...
Synthetic study on the Biological Functions of Glycoconjugates
Design and Synthesis of Bio - active Compounds Derived from Glycoconjugates