2008年1月
A practical synthesis of (E)-2-cyclopentadecen-1-one: an important precursor of macrocyclic muscone
TETRAHEDRON LETTERS
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- 巻
- 49
- 号
- 3
- 開始ページ
- 548
- 終了ページ
- 551
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.tetlet.2007.11.065
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
A practical synthesis of (E)-2-cyclopentadecen-1-one (E)-2 which is an important precursor of macrocyclic muscone (1) was investigated. Olefination of 2-mesyloxycyclopentadecanone (7c) with strong acid such as sulfuric acid or trifluoromethanesulfonic acid afforded the desired (E)-2 in high yield with extremely high stereo selectivity, which was treated with methylmagnesium cuprate to furnish the dl-muscone in good yield. (C) 2007 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tetlet.2007.11.065
- ISSN : 0040-4039
- CiNii Articles ID : 80017986027
- Web of Science ID : WOS:000253061900033