論文

査読有り 国際誌
2020年5月6日

Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish.

Molecular brain
  • Shiho Suzuki
  • ,
  • Ryo Kimura
  • ,
  • Shingo Maegawa
  • ,
  • Masatoshi Nakata
  • ,
  • Masatoshi Hagiwara

13
1
開始ページ
70
終了ページ
70
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1186/s13041-020-00614-4

Attention deficit-hyperactivity disorder (ADHD) is a prevalent neuropsychiatric disorder found in children. It is characterized by inattention, hyperactivity, and impulsivity. Methylphenidate (MPH) and atomoxetine (ATX) are commonly prescribed for the treatment of ADHD. In the present study, we examined the behavioral and brain transcriptome changes in MPH-treated and ATX-treated zebrafish. In behavioral analysis, zebrafish showed opposite response to each treatment. MPH-treated fish showed higher anxiety-like behavior while ATX-treated fish showed lower anxiety-like behavior. Further, we performed RNA sequencing analysis of zebrafish brain to elucidate the underlying biological pathways associated with MPH and ATX treatment. Interestingly, we found that shared differentially expressed genes in MPH-treated and ATX-treated fish were instrumental in cholesterol biosynthesis pathway and were regulated in opposite manner. Our findings highlight the contrast between MTH and ATX, and may suggest the alterations in clinical practice for these medications and drug development for ADHD.

リンク情報
DOI
https://doi.org/10.1186/s13041-020-00614-4
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32375837
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203832

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