論文

査読有り 国際誌
2020年10月13日

Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage.

Stem cell reports
  • Akihide Takeuchi
  • ,
  • Yuji Takahashi
  • ,
  • Kei Iida
  • ,
  • Motoyasu Hosokawa
  • ,
  • Koichiro Irie
  • ,
  • Mikako Ito
  • ,
  • J B Brown
  • ,
  • Kinji Ohno
  • ,
  • Kinichi Nakashima
  • ,
  • Masatoshi Hagiwara

15
4
開始ページ
883
終了ページ
897
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.stemcr.2020.08.010

During brain development, neural stem cells (NSCs) initially produce neurons and change their fate to generate glias. While the regulation of neurogenesis is well characterized, specific markers for glial precursor cells (GPCs) and the master regulators for gliogenesis remain unidentified. Accumulating evidence suggests that RNA-binding proteins (RBPs) have significant roles in neuronal development and function, as they comprehensively regulate the expression of target genes in a cell-type-specific manner. We systematically investigated the expression profiles of 1,436 murine RBPs in the developing mouse brain and identified quaking (Qk) as a marker of the putative GPC population. Functional analysis of the NSC-specific Qk-null mutant mouse revealed the key role of Qk in astrocyte and oligodendrocyte generation and differentiation from NSCs. Mechanistically, Qk upregulates gliogenic genes via quaking response elements in their 3' untranslated regions. These results provide crucial directions for identifying GPCs and deciphering the regulatory mechanisms of gliogenesis from NSCs.

リンク情報
DOI
https://doi.org/10.1016/j.stemcr.2020.08.010
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32976762

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