論文

査読有り
2017年7月

Regional Spread of CTX-M-2-Producing Proteus mirabilis with the Identical Genetic Structure in Japan

MICROBIAL DRUG RESISTANCE
  • Karin Kato
  • ,
  • Yasufumi Matsumura
  • ,
  • Masaki Yamamoto
  • ,
  • Miki Nagao
  • ,
  • Shunji Takakura
  • ,
  • Satoshi Ichiyama

23
5
開始ページ
590
終了ページ
595
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1089/mdr.2016.0148
出版者・発行元
MARY ANN LIEBERT, INC

Aims: In this study, we analyzed the molecular epidemiology of extended-spectrum -lactamase (ESBL)-producing Proteus mirabilis isolates collected from the central region of Japan. Materials and Methods: Between 2005 and 2012, 820 clinical P. mirabilis isolates were obtained from ten acute care hospitals in Japan. We characterized ESBL confirmatory test-positive isolates by sequencing the ESBL genes and their flanking regions, detecting plasmid replicons, and performing pulsed-field gel electrophoresis (PFGE). Results: Ninety-six isolates (12%) were positive according to the ESBL confirmatory test; all these isolates possessed bla(CTX-M-2) with the same flanking structure of upstream ISEcp1 and a downstream region identical to downstream bla(KLUA-1). IncT was the prevalent, and only, replicon found in 63 isolates. PFGE analysis detected eight clusters with more than one isolate, among which three included 56 isolates and six included isolates from multiple hospitals. Conclusion: CTX-M-2-producing P. mirabilis with an identical genetic structure flanking bla(CTX-M-2) is dominant in this Japanese region, and there is evidence for the clonal spread of isolates.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1089/mdr.2016.0148
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27834610
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404988200007&DestApp=WOS_CPL