2007年9月
Demonstration of the importance of metal ion speciation in bioactive systems
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
- ,
- 巻
- 80
- 号
- 9
- 開始ページ
- 1691
- 終了ページ
- 1702
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1246/bcsj.80.1691
- 出版者・発行元
- CHEMICAL SOC JAPAN
This paper gives insight into chemical speciation. After a brief introduction, the methods available to study solution state of metal ions and the importance of speciation in biology are discussed through different examples. Speciation of toxic Al-III, beneficial Cu-II and Ca-II and potentially medicinal Pd-II and VOIV in various biofluids and tissues is discussed in order to describe the solution state of these metal ions in an organism. The relevance of ternary complex formation with endogenous biomolecules is emphasised. The importance of the biospeciation of Al-III ion in its transport and involvement in neurological disorders, of the actual chemical form of the insulin-mimetic VOIV complexes in its biological occurrence and Call in mineralization/demineralization processes is discussed. The role of time, i.e., the kinetic aspects of biospeciation, is discussed in the case of the transport of Al-III and Cu-II and some Pd-II, complexes (models of the anticancer Pt-II complexes) in blood serum.
- リンク情報
- ID情報
-
- DOI : 10.1246/bcsj.80.1691
- ISSN : 0009-2673
- eISSN : 1348-0634
- Web of Science ID : WOS:000250360400004