Multicomponent packed column distillation is simulated using a rate-based model and the simulation results are compared with the experimental results obtained from a 0.2 m diameter pilot-scale packed column. The simulation algorithm used is previously proposed by the authors, which based on an equation-tearing method for (6c+7) equations of one packing segment and the whole column is solved by an iterative segmentwise calculation with the overall normalized theta method for acceleration. The performance of two packings is examined by simulating the pilot-scale column experiments using the published correlations for estimating liquid and vapor phase mass transfer coefficients and an effective interfacial area.